Product image of Inderal (Propranolol) supplied by GNH India

Inderal

Active Ingredient:
Propranolol
Origin:
EU

Inderal (Propranolol)

Propranolol, the active ingredient in Inderal, is a beta blocker presented as an oral dosage form for oral use. It treats hypertension, angina pectoris, cardiac arrhythmias, myocardial infarction prophylaxis, migraine prophylaxis, and essential tremor in adult patients.

GNH India supplies Inderal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Atnahs Pharma Netherlands B.V.

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Indications & Clinical Uses

Propranolol acts on the cardiovascular and nervous systems to control blood pressure, heart rhythm, and vascular tone.

  • Hypertension: lowers blood pressure by reducing heart rate, myocardial contractility, and renin release.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Cardiac arrhythmias: stabilises abnormal heart rhythms by slowing conduction through the AV node.
  • Myocardial infarction prophylaxis: reduces risk of recurrent infarction by limiting cardiac workload.
  • Migraine prophylaxis: prevents migraine attacks through vascular stabilisation.
  • Essential tremor: diminishes tremor amplitude by dampening peripheral beta‑adrenergic activity.

How It Works

  • Propranolol is a non‑selective antagonist of β1 and β2 adrenergic receptors. By blocking β1 receptors in the heart, it reduces heart rate, contractility, and renin secretion, leading to lower cardiac output and blood pressure. β2 blockade in peripheral vessels and bronchial smooth muscle contributes to decreased vasodilation and can affect bronchial tone. The combined effect results in diminished sympathetic stimulation across multiple organ systems.

Side Effects

Propranolol may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Fatigue or tiredness
  • Dizziness or light‑headedness
  • Cold hands and feet
  • Gastrointestinal upset (nausea, abdominal discomfort)
  • Sleep disturbances (insomnia or vivid dreams)
  • Mild bradycardia

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in asthmatic patients
  • Acute heart failure exacerbation
  • Masking of hypoglycaemia symptoms in diabetics
  • Depression or mood changes

Precautions & Warnings

Before prescribing propranolol, clinicians should evaluate patient‑specific factors and monitor for adverse outcomes.

  • Assess cardiovascular status: check baseline heart rate, blood pressure, and ECG.
  • Review respiratory history: avoid in uncontrolled asthma or severe COPD.
  • Monitor glucose control: patients with diabetes may experience masked hypoglycaemia.
  • Evaluate for depression: beta‑blockers can exacerbate mood disorders.
  • Adjust dose cautiously in renal or hepatic impairment.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Propranolol interacts with several drug classes; careful management is required.

Major Interactions (Avoid)

  • Asthma or severe COPD medications: non‑selective β‑blockade may precipitate bronchospasm.
  • Calcium channel blockers (verapamil, diltiazem): increased risk of AV block and bradycardia.
  • Insulin or oral hypoglycaemic agents: may mask hypoglycaemia symptoms.
  • MAO inhibitors: can cause hypertensive crisis.
  • Other β‑blockers: additive cardiac depression.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, diuretics): may enhance hypotensive effect.
  • Digoxin: increased risk of bradyarrhythmias.
  • Antidepressants (SSRIs, tricyclics): potential for additive CNS effects.
  • NSAIDs: may reduce antihypertensive efficacy.
  • Antithyroid drugs: may alter thyroid hormone levels.

Frequently Asked Questions

Inderal, whose active ingredient is propranolol, is prescribed for several cardiovascular and neurological conditions. It is commonly used to manage hypertension, angina pectoris, various cardiac arrhythmias, and to reduce the risk of recurrent myocardial infarction. Additionally, propranolol is effective for migraine prophylaxis and for reducing the severity of essential tremor.

Propranolol works by non‑selectively blocking β1 and β2 adrenergic receptors. In the heart, β1 blockade lowers heart rate and contractility, decreasing cardiac output and blood pressure. β2 blockade reduces vasodilation and can affect bronchial smooth muscle tone. The overall effect is a reduction in sympathetic nervous system activity, which helps control blood pressure, heart rhythm, and vascular responses.

The appropriate dose of Inderal is individualized by a qualified prescriber based on the specific indication, patient age, weight, renal and hepatic function, and response to therapy. Dosage regimens can vary widely, and any adjustments should be made under medical supervision to ensure safety and efficacy.

The safety of propranolol during pregnancy and lactation has not been definitively established, and it is classified as a pregnancy category with unknown risk. Healthcare providers should weigh potential benefits against possible risks, and alternative therapies may be considered. Breastfeeding mothers should discuss potential infant exposure with their clinician.

To place an order, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Inderal (propranolol) is a non‑selective beta blocker, meaning it blocks both β1 and β2 receptors. Some alternatives, such as atenolol or metoprolol, are cardio‑selective (β1‑selective) and may be preferred in patients with respiratory concerns. The choice depends on the clinical scenario, patient comorbidities, and physician judgment.

Inderal should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Inderal is taken orally, usually in tablet form, with or without food as directed by the prescribing clinician. The exact administration schedule—such as once daily or divided doses—depends on the therapeutic indication and the individual patient's response.

Serious risks include severe bradycardia, marked hypotension, bronchospasm in patients with asthma or COPD, heart block, and masking of hypoglycaemia symptoms in diabetic individuals. Patients should be monitored closely for these events, especially during dose initiation or titration.

Inderal is contraindicated in patients with known hypersensitivity to propranolol or any component of the formulation, those with severe bradycardia, second‑ or third‑degree heart block without a pacemaker, uncontrolled asthma or severe chronic obstructive pulmonary disease, and in individuals experiencing cardiogenic shock.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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