Product image of Inderal (Propranolol Hydrochloride) supplied by GNH India

Inderal

Active Ingredient:
Propranolol Hydrochloride
Origin:
EU

Inderal (Propranolol Hydrochloride)

Propranolol Hydrochloride, the active ingredient in Inderal, is a beta blocker presented as an oral tablet for systemic use. It lowers blood pressure, reduces heart workload, and is employed in the management of several cardiovascular and neurological conditions in adult patients.

GNH India supplies Inderal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance.

Manufacturer / TM Owner

Atnahs Pharma Netherlands B.V.

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Indications & Clinical Uses

Inderal (propranolol hydrochloride) is used to treat conditions within the cardiovascular and neurological disease families by modulating β‑adrenergic activity.

  • Hypertension: lowers systemic blood pressure by decreasing heart rate and cardiac output.
  • Angina pectoris: reduces myocardial oxygen demand, relieving chest pain during exertion.
  • Cardiac arrhythmias: stabilises abnormal heart rhythms by slowing conduction through the AV node.
  • Myocardial infarction prophylaxis: decreases risk of recurrent heart attacks after an initial event.
  • Migraine prophylaxis: prevents migraine attacks by modulating vascular tone.
  • Essential tremor: diminishes tremor amplitude through central β‑adrenergic blockade.

How It Works

  • Propranolol hydrochloride is a non‑selective antagonist of β1 and β2 adrenergic receptors. By blocking these receptors, it reduces sympathetic stimulation of the heart, leading to decreased heart rate, contractility, and renin release, while also influencing vascular smooth‑muscle tone and central nervous system pathways.

Side Effects

Propranolol may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Fatigue or tiredness
  • Dizziness or light‑headedness
  • Cold hands and feet
  • Gastrointestinal upset (nausea, abdominal discomfort)
  • Sleep disturbances or vivid dreams
  • Bradycardia (slow heart rate)

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in asthmatic patients
  • Masking of hypoglycaemia symptoms in diabetics
  • Depression or mood changes

Precautions & Warnings

When prescribing Inderal, clinicians should observe several precautionary measures to ensure safe use.

  • Cardiovascular assessment: evaluate heart rate and blood pressure before initiation.
  • Diabetes monitoring: monitor blood glucose as beta‑blockers may mask hypoglycaemia symptoms.
  • Abrupt discontinuation: taper the dose to avoid rebound tachycardia or hypertension.
  • Respiratory caution: use with care in patients with asthma or chronic obstructive pulmonary disease.
  • Renal/hepatic impairment: adjust dose in patients with reduced organ function.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Propranolol interacts with several drug classes; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid)

  • Other non‑selective β‑blockers: additive β‑adrenergic blockade may cause severe bradycardia.
  • Calcium channel blockers (verapamil, diltiazem): combined effect can lead to marked heart block or hypotension.
  • Clonidine withdrawal: abrupt cessation while on propranolol may precipitate hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may enhance antihypertensive effect, requiring blood pressure monitoring.
  • ACE inhibitors or ARBs: combined therapy can increase risk of hypotension, especially in volume‑depleted patients.

Frequently Asked Questions

Inderal, containing propranolol hydrochloride, is prescribed for several cardiovascular and neurological conditions. It is commonly used to manage hypertension, angina pectoris, various cardiac arrhythmias, prevention of recurrent myocardial infarction, migraine prophylaxis, and essential tremor in adult patients.

Propranolol works by non‑selectively blocking β1 and β2 adrenergic receptors. This inhibition reduces the effects of adrenaline and noradrenaline, leading to a slower heart rate, decreased myocardial contractility, lower renin release, and modulation of vascular tone, which together lower blood pressure and stabilize heart rhythm.

The appropriate dose of Inderal is individualized by the prescribing clinician based on the specific indication, severity of disease, patient age, weight, renal and hepatic function, and any concomitant medications. Dosage adjustments are made to achieve therapeutic goals while minimizing adverse effects.

Propranolol is classified as a pregnancy‑category drug that should be used only if the potential benefit justifies the potential risk to the fetus. It passes into breast milk, so breastfeeding mothers should discuss risks and alternatives with their healthcare provider before continuing therapy.

To order Inderal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Inderal is a non‑selective beta‑blocker, meaning it blocks both β1 and β2 receptors, which can be advantageous for conditions like migraine prophylaxis and essential tremor. Selective β1‑blockers (e.g., atenolol) may have fewer respiratory side effects, while alternative classes such as calcium‑channel blockers address hypertension through different mechanisms.

Inderal should be stored at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture and direct sunlight to maintain stability and potency throughout the shelf life.

Inderal is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact dosing schedule—such as once daily or divided doses—is determined by the treating physician based on the indication and patient response.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with asthma or COPD, and masking of hypoglycaemia symptoms in diabetic individuals. Prompt medical attention is required if any of these events occur.

Inderal should not be used by patients with uncontrolled asthma, severe chronic obstructive pulmonary disease, second‑ or third‑degree heart block without a pacemaker, severe bradycardia, or those experiencing cardiogenic shock. It is also contraindicated in individuals with known hypersensitivity to propranolol or any excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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