Product image of Inderal (Propranolol Hydrochloride) supplied by GNH India

Inderal

Active Ingredient:
Propranolol Hydrochloride
Origin:
EU

Inderal (Propranolol Hydrochloride)

Propranolol Hydrochloride, the active ingredient in Inderal, is a beta blocker presented as an oral tablet for oral use. It is used to manage high blood pressure, chest pain, irregular heart rhythms, migraine prevention, essential tremor, and certain endocrine tumors.
GNH India supplies Inderal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Atnahs Pharma Netherlands B.V.

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Indications & Clinical Uses

Inderal is a non‑selective beta‑adrenergic antagonist that acts on cardiovascular and neurological pathways.

  • Hypertension: lowers blood pressure by reducing heart rate, myocardial contractility and renin release.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Cardiac arrhythmias: stabilises abnormal heart rhythms by slowing conduction through the AV node.
  • Migraine prophylaxis: reduces frequency of migraine attacks through vascular modulation.
  • Essential tremor: diminishes tremor amplitude by dampening peripheral sympathetic activity.
  • Pheochromocytoma: controls catecholamine‑induced hypertension during pre‑operative management.

How It Works

  • Propranolol Hydrochloride is a non‑selective β‑adrenergic receptor antagonist that blocks β1 and β2 receptors in the heart, blood vessels, and peripheral tissues. This inhibition reduces heart rate, myocardial contractility, and renin release, leading to decreased cardiac output and lowered systemic blood pressure. It also attenuates sympathetic stimulation of vascular smooth muscle, contributing to its anti‑anginal and anti‑migraine effects.

Side Effects

Common Side Effects

  • Fatigue: feeling unusually tired or weak.
  • Dizziness: light‑headedness, especially when standing quickly.
  • Cold extremities: reduced blood flow to hands and feet.
  • Gastrointestinal upset: nausea, stomach discomfort or diarrhea.
  • Sleep disturbances: insomnia or vivid dreams.

Serious or Rare Side Effects

  • Bradycardia: abnormally slow heart rate that may cause fainting.
  • Hypotension: significant drop in blood pressure leading to dizziness or shock.
  • Bronchospasm: tightening of airway muscles, especially in asthmatic patients.
  • Heart block: impaired electrical conduction causing arrhythmias.
  • Severe depression or mood changes.
  • Allergic reactions: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before starting Inderal, consider the following precautions:

  • Cardiovascular assessment: evaluate heart rate and blood pressure to ensure suitability.
  • Respiratory conditions: avoid in patients with active asthma or severe chronic obstructive pulmonary disease.
  • Diabetes monitoring: beta‑blockade can mask hypoglycaemic symptoms; check glucose levels regularly.
  • Thyroid disorders: use cautiously in hyperthyroidism as symptoms may be concealed.
  • Discontinuation: taper the dose gradually to prevent rebound hypertension or tachycardia.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture.

Avoid Interactions

Propranolol may interact with several medicines; review the following groups:

Major Interactions (Avoid)

  • Severe asthma: non‑selective beta‑blockade can precipitate bronchospasm.
  • Calcium channel blockers (verapamil, diltiazem): combined effect may cause profound bradycardia or heart block.
  • Insulin or sulfonylureas: beta‑blockade may mask hypoglycaemia signs.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs, SNRIs): may increase propranolol plasma concentrations.
  • Antithyroid drugs: propranolol can alter thyroid hormone levels, requiring dose adjustment.
  • NSAIDs: may reduce the antihypertensive efficacy of propranolol.

Frequently Asked Questions

Inderal, containing propranolol hydrochloride, is prescribed for high blood pressure, angina pectoris, certain cardiac arrhythmias, migraine prevention, essential tremor, and to control blood pressure in pheochromocytoma before surgery.

Propranolol blocks both β1 and β2 adrenergic receptors, reducing heart rate, myocardial contractility, and renin release. This leads to lower cardiac output and blood pressure, while also dampening sympathetic activity that contributes to migraine and tremor.

The specific dose of Inderal is determined by the prescribing clinician based on the patient’s condition, age, weight, and response to therapy. Dosage regimens are individualized and should follow the healthcare professional’s instructions.

Safety data for propranolol in pregnancy are limited, and the drug is generally used only if the potential benefit outweighs the risk. It is excreted in breast milk, so a healthcare provider should evaluate the need for therapy while nursing.

To request Inderal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Inderal is a non‑selective beta blocker, affecting both β1 and β2 receptors, whereas agents like atenolol are β1‑selective. Non‑selective blockade offers broader therapeutic effects for migraine and tremor but may carry higher risk of bronchospasm in asthmatic patients.

Inderal tablets should be stored at ambient temperature, preferably below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children.

Inderal is taken orally, usually with a glass of water. It can be taken with or without food, but consistency with meals helps maintain stable absorption. Follow the prescribing clinician’s schedule for timing and frequency.

Serious risks include severe bradycardia, marked hypotension, bronchospasm in patients with reactive airway disease, and heart block. Patients should seek immediate medical attention if they experience fainting, difficulty breathing, or a rapid change in heart rhythm.

Inderal is contraindicated in patients with uncontrolled asthma, severe chronic obstructive pulmonary disease, second‑ or third‑degree heart block without a pacemaker, and in those with known hypersensitivity to propranolol or any excipients in the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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