Product image of Inderal (Propranolol Hydrochloride) supplied by GNH India

Inderal

Active Ingredient:
Propranolol Hydrochloride
Origin:
EU

Inderal (Propranolol Hydrochloride)

Propranolol, the active ingredient in Inderal, is a beta blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, chest pain, irregular heart rhythms, migraine prevention and several other cardiovascular and neurological conditions.

GNH India supplies Inderal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Atnahs Pharma Netherlands B.V.

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Indications & Clinical Uses

Inderal is a non‑selective beta‑adrenergic antagonist used across several cardiovascular and neurological disease pathways.

  • Hypertension: lowers elevated blood pressure by reducing cardiac output and renin release.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain during exertion.
  • Cardiac arrhythmias: stabilises abnormal heart rhythms by slowing conduction through the AV node.
  • Migraine prophylaxis: reduces frequency and severity of migraine attacks through vascular modulation.

How It Works

  • Propranolol blocks β1 and β2 adrenergic receptors throughout the body, inhibiting the effects of endogenous catecholamines such as epinephrine and norepinephrine. This antagonism reduces heart rate, myocardial contractility, and renin secretion, leading to decreased cardiac output and lower blood pressure, while also dampening peripheral vascular responses that contribute to migraine and tremor.

Side Effects

Common Side Effects

  • Fatigue or tiredness
  • Dizziness or light‑headedness
  • Cold hands and feet
  • Nausea or mild stomach upset
  • Sleep disturbances or vivid dreams
  • Bradycardia (slow heart rate)

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm or severe asthma exacerbation
  • Allergic reactions such as rash, swelling, or anaphylaxis
  • Depression or mood changes
  • Worsening of heart failure

Precautions & Warnings

Before initiating therapy, clinicians should assess patient‑specific factors and monitor for adverse outcomes.

  • Blood pressure monitoring: check regularly to avoid excessive hypotension.
  • Cardiac function review: evaluate for underlying heart block or severe bradycardia.
  • Respiratory caution: avoid in uncontrolled asthma or severe chronic obstructive pulmonary disease.
  • Diabetes management: monitor glucose as beta‑blockade may mask hypoglycaemia symptoms.
  • Renal/hepatic impairment: dose adjustment may be required in reduced clearance.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Propranolol may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Asthma or COPD medications: non‑selective blockade can precipitate bronchospasm.
  • Severe bradycardia or AV‑block agents: additive slowing of cardiac conduction.
  • Certain anti‑arrhythmic drugs (e.g., digoxin): increased risk of heart block.

Moderate Interactions (Monitor Closely)

  • Insulin or oral hypoglycaemics: may mask hypoglycaemia signs.
  • Calcium‑channel blockers (verapamil, diltiazem): can enhance bradycardia and hypotension.
  • Antidepressants (SSRIs, SNRIs): may increase risk of serotonin syndrome when combined with other serotonergic agents.

Frequently Asked Questions

Inderal, containing propranolol, is prescribed to treat high blood pressure, chest pain from angina, certain cardiac arrhythmias, to prevent migraine attacks, and to manage essential tremor and hyperthyroidism‑related symptoms. The specific indication depends on the patient’s clinical profile and the prescribing physician’s assessment.

Propranolol blocks both β1 and β2 adrenergic receptors, preventing adrenaline and noradrenaline from activating these pathways. This reduces heart rate, contractility, and renin release, leading to lower blood pressure and decreased cardiac workload, while also stabilising vascular tone that contributes to migraine and tremor control.

The dosage of Inderal is individualized by the prescribing clinician based on the patient’s condition, age, weight, renal and hepatic function, and response to therapy. Only a qualified healthcare professional should determine the appropriate dose and schedule.

Safety of propranolol in pregnancy or while nursing has not been definitively established. Physicians weigh potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives and monitoring strategies with their healthcare provider.

To request Inderal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Inderal (propranolol) is a non‑selective beta blocker, affecting both β1 and β2 receptors, whereas some alternatives such as atenolol or metoprolol are β1‑selective. Non‑selectivity offers broader therapeutic effects for migraine and tremor but may increase the risk of bronchospasm in patients with reactive airway disease.

Inderal should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and potency throughout its shelf life.

Inderal is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact timing (e.g., once daily or divided doses) is determined by the treating physician based on the therapeutic goal and patient tolerance.

Serious risks include severe bradycardia, profound hypotension, bronchospasm in patients with asthma or COPD, heart block, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience fainting, difficulty breathing, or rapid swelling.

Inderal is contraindicated in individuals with known hypersensitivity to propranolol, uncontrolled asthma, severe chronic obstructive pulmonary disease, certain types of heart block, or profound bradycardia. It should also be used with caution in patients with diabetes, peripheral vascular disease, or severe liver impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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