Product image of Inderal (Propranolol Hydrochloride) supplied by GNH India

Inderal

Active Ingredient:
Propranolol Hydrochloride
Origin:
EU

Inderal (Propranolol Hydrochloride)

Propranolol, the active ingredient in Inderal, is a beta blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, angina pectoris, cardiac arrhythmias, myocardial infarction prophylaxis, migraine prevention, and essential tremor in adult patients under medical supervision and is prescribed by qualified healthcare professionals in various therapeutic settings.

GNH India supplies Inderal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and transplant centres worldwide through regulated distribution channels.

Manufacturer / TM Owner

Atnahs Pharma Netherlands B.V.

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Indications & Clinical Uses

Inderal, a non‑selective beta‑adrenergic antagonist, is used in several cardiovascular and neurological conditions:

  • Hypertension: lowers blood pressure by reducing cardiac output and inhibiting renin release.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Cardiac arrhythmias: stabilises heart rhythm by slowing conduction through the AV node.
  • Myocardial infarction prophylaxis: reduces risk of recurrent heart attacks after an initial event.
  • Migraine prophylaxis: prevents migraine attacks by modulating vascular tone.
  • Essential tremor: diminishes tremor amplitude through central beta‑blockade.

How It Works

  • Propranolol blocks beta‑1 and beta‑2 adrenergic receptors throughout the body, preventing catecholamines such as epinephrine and norepinephrine from activating these receptors. This results in decreased heart rate, reduced myocardial contractility, lowered renin secretion, and diminished peripheral vascular resistance, collectively contributing to its antihypertensive, anti‑anginal, anti‑arrhythmic, and migraine‑preventive effects.

Side Effects

Common Side Effects

  • Fatigue or tiredness.
  • Dizziness or light‑headedness.
  • Cold hands and feet.
  • Gastrointestinal upset such as nausea or abdominal discomfort.
  • Sleep disturbances, including vivid dreams.
  • Mild bradycardia.

Serious or Rare Side Effects

  • Severe bradycardia or heart block.
  • Marked hypotension.
  • Bronchospasm, especially in patients with asthma or COPD.
  • Acute heart failure exacerbation.
  • Hypoglycaemia unawareness in diabetic patients.
  • Depression or mood changes.

Precautions & Warnings

Before initiating Inderal, consider the following precautions:

  • Cardiovascular assessment: evaluate heart rate and blood pressure to ensure suitability.
  • Respiratory conditions: avoid in patients with active asthma or severe COPD due to risk of bronchospasm.
  • Diabetes monitoring: beta‑blockade may mask hypoglycaemia symptoms; monitor glucose closely.
  • Discontinuation: taper gradually to prevent rebound hypertension or tachycardia.
  • Pregnancy and lactation: use only if potential benefits outweigh risks.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original container.

Avoid Interactions

Propranolol may interact with several medicines; monitor as indicated:

Major Interactions (Avoid)

  • Co‑administration with other bradycardic agents (e.g., verapamil, diltiazem) can cause severe heart block.
  • Combined use with insulin or sulfonylureas may mask hypoglycaemia signs.
  • Potent CYP2D6 inhibitors (e.g., quinidine) can raise propranolol plasma levels.

Moderate Interactions (Monitor Closely)

  • Concurrent antihypertensives may enhance hypotensive effects.
  • Certain antidepressants (e.g., SSRIs) may require dose adjustments.
  • NSAIDs can attenuate the antihypertensive efficacy of propranolol.

Frequently Asked Questions

Inderal, containing propranolol, is prescribed for high blood pressure, angina chest pain, certain heart rhythm disorders, prevention of repeat heart attacks, migraine prevention, and essential tremor. It works across cardiovascular and neurological pathways to control symptoms in these recognized indications.

Propranolol blocks both beta‑1 and beta‑2 adrenergic receptors, preventing adrenaline and noradrenaline from stimulating the heart and blood vessels. This reduces heart rate, contractility, and renin release, leading to lower blood pressure, decreased cardiac workload, and stabilization of abnormal heart rhythms.

The dosage of Inderal is individualized by a qualified prescriber based on the specific condition, patient age, weight, and response to therapy. Healthcare professionals determine the appropriate strength, frequency, and titration schedule for each patient.

Safety of Inderal in pregnancy or while nursing has not been definitively established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To request Inderal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Inderal is a non‑selective beta‑blocker, meaning it blocks both beta‑1 and beta‑2 receptors, unlike cardio‑selective agents that primarily affect beta‑1. This broader activity can be advantageous for migraine prophylaxis and tremor but may require caution in patients with respiratory disease.

Inderal should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and ensure the container is tightly closed to maintain product stability.

Inderal is taken orally, usually with or without food, as directed by the prescribing clinician. Tablets should be swallowed whole with a full glass of water and not crushed or chewed unless specifically instructed.

Serious risks include severe bradycardia, marked hypotension, bronchospasm in patients with asthma or COPD, and masking of hypoglycaemia symptoms in diabetic individuals. Prompt medical attention is required if any of these events occur.

Inderal is contraindicated in patients with known hypersensitivity to propranolol, severe bradycardia, second‑ or third‑degree heart block without a pacemaker, uncompensated heart failure, and uncontrolled asthma or severe chronic obstructive pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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