Product image of Inderm (Erythromycin) supplied by GNH India

Inderm

Active Ingredient:
Erythromycin
Origin:
EU

Inderm (Erythromycin)

Erythromycin, the active ingredient in Inderm, is a macrolide antibiotic presented as a topical formulation for skin use. It treats acne vulgaris and other superficial bacterial skin infections in patients who require localized therapy.

GNH India supplies Inderm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dermapharm Ag

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Indications & Clinical Uses

  • Inderm, a topical macrolide antibiotic, is employed to manage bacterial skin conditions.
  • Acne vulgaris: reduces inflammatory lesions and bacterial colonisation on the face and trunk.
  • Impetigo: eradicates Staphylococcus aureus or Streptococcus pyogenes causing superficial crusted lesions.
  • Folliculitis: clears infected hair follicles and alleviates associated redness and pustules.

How It Works

  • Erythromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents peptide chain elongation, halting bacterial growth and allowing the host immune system to clear the infection. The action is bacteriostatic against most susceptible organisms and bactericidal at higher concentrations.

Side Effects

Topical erythromycin may cause local adverse reactions, ranging from mild irritation to rare severe events.

Common Side Effects

  • Skin irritation or burning sensation at the application site.
  • Pruritus (itching) localized to treated area.
  • Redness or erythema.
  • Dryness or peeling of the skin.
  • Contact dermatitis.
  • Mild scaling.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Severe photosensitivity leading to blistering.
  • Systemic absorption causing hepatic dysfunction (rare).
  • Severe ulceration or necrosis of skin.
  • Persistent or worsening infection indicating resistance.

Precautions & Warnings

  • Before using Inderm, consider the following safety measures.
  • Pregnancy Category B: use only if the potential benefit justifies the potential risk.
  • Breastfeeding: caution advised; monitor infant for adverse effects.
  • Known hypersensitivity to erythromycin or other macrolides: avoid use.
  • Application on broken or inflamed skin may increase systemic absorption; limit use.
  • Concurrent use with other topical antibiotics may promote resistance; avoid combination unless directed.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Topical erythromycin can interact with other agents, affecting safety or efficacy.

Major Interactions (Avoid)

  • Concurrent use with other macrolide antibiotics may increase systemic exposure.
  • Combined topical clindamycin may heighten risk of bacterial resistance.

Moderate Interactions (Monitor Closely)

  • Use with photosensitising agents (e.g., retinoids) may increase sunburn risk.
  • Application alongside other skin irritants can exacerbate local reactions.
  • Systemic absorption in extensive use may interact with warfarin; monitor INR if applicable.

Frequently Asked Questions

Inderm is a topical formulation of erythromycin indicated for the treatment of acne vulgaris and other superficial bacterial skin infections such as impetigo and folliculitis. It works by reducing bacterial colonisation and inflammation on the skin.

Erythromycin in Inderm binds to the 50S ribosomal subunit of susceptible bacteria, blocking protein synthesis. This inhibition stops bacterial growth, allowing the body’s immune system to eliminate the infection and reduce associated skin inflammation.

The dosage of Inderm is determined by the prescribing healthcare professional based on the severity of the skin condition, patient age, and treatment response. Patients should follow the prescriber’s instructions and the product label for application frequency and duration.

Inderm is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are no adequate human studies. It may be used during pregnancy only if the potential benefit justifies any potential risk. Caution is advised during breastfeeding, and a healthcare provider should be consulted.

To order Inderm, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any required import documentation.

Inderm (erythromycin) belongs to the macrolide class, offering a broad spectrum against Gram‑positive bacteria and some atypicals. Compared with topical clindamycin, erythromycin has a lower risk of resistance when used alone but may be combined for synergistic effect. Choice depends on bacterial profile, patient tolerance and prescriber preference.

Inderm should be stored at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Inderm is applied topically to the affected skin area. Clean and dry the skin before use, then spread a thin layer of the product over the lesion(s) as directed by the prescriber, usually once or twice daily. Hands should be washed after application.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and significant photosensitivity. Patients should discontinue use and seek immediate medical attention if they experience widespread rash, blistering, or signs of systemic allergy.

Inderm should not be used by individuals with a known hypersensitivity to erythromycin, other macrolide antibiotics, or any component of the formulation. It is also contraindicated on extensive broken skin where systemic absorption could be significant, unless specifically directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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