Product image of Inderm (Erythromycin) supplied by GNH India

Inderm

Active Ingredient:
Erythromycin
Origin:
EU

Inderm (Erythromycin)

Erythromycin, the active ingredient in Inderm, is a macrolide antibiotic presented as a topical formulation for topical use. It treats acne vulgaris and superficial skin infections by targeting susceptible bacteria on the skin surface.
GNH India supplies Inderm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Centrafarm B.V.

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Indications & Clinical Uses

  • Erythromycin is a macrolide antibiotic used for bacterial skin conditions that respond to topical therapy.
  • Acne vulgaris: reduces inflammatory lesions and bacterial colonisation on the skin.
  • Superficial skin infections: eradicates susceptible organisms causing impetigo, erysipelas or cellulitis of limited depth.
  • Impetigo: clears Staphylococcus aureus or Streptococcus pyogenes infection and promotes healing of crusted lesions.

How It Works

  • Erythromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents bacterial growth and replication, exerting a bacteriostatic effect against susceptible Gram‑positive and some Gram‑negative organisms that colonise the skin.

Side Effects

Topical erythromycin may cause local skin reactions and, rarely, systemic hypersensitivity.

Common Side Effects

  • Skin irritation or burning sensation at the application site.
  • Itching or pruritus.
  • Redness (erythema) of the treated area.
  • Dryness or peeling of the skin.
  • Mild contact dermatitis.
  • Stinging sensation.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with swelling, hives, or difficulty breathing.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Drug‑induced liver injury (hepatitis) reported with extensive absorption.
  • Serum sickness‑like reaction.
  • Persistent ulceration or necrosis of the skin.

Precautions & Warnings

Before using Inderm, consider the following safety measures.

  • Allergy assessment: avoid if the patient has known hypersensitivity to macrolides.
  • Skin integrity: do not apply on open wounds or severely damaged skin.
  • Monitor for systemic effects: watch for signs of gastrointestinal upset or liver dysfunction.
  • Concomitant topical antibiotics: limit combined use to reduce resistance risk.
  • Eye protection: keep product away from eyes and mucous membranes.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Erythromycin can interact with other medicines, affecting safety or efficacy.

Major Interactions (Avoid)

  • Co‑administration with other macrolide antibiotics: may increase systemic exposure and toxicity.
  • Drugs that prolong the QT interval (e.g., certain antiarrhythmics): risk of cardiac arrhythmias.
  • Concurrent use with topical corticosteroids: may mask signs of infection.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise erythromycin levels.
  • Antacids containing aluminum or magnesium: could reduce local absorption.
  • Warfarin: monitor INR as erythromycin may enhance anticoagulant effect.

Frequently Asked Questions

Inderm is a topical formulation of erythromycin indicated for the treatment of acne vulgaris, superficial bacterial skin infections such as impetigo, and other limited‑depth infections where a macrolide antibiotic is appropriate.

Erythromycin in Inderm binds to the bacterial 50S ribosomal subunit, blocking protein synthesis. This bacteriostatic action stops the growth of susceptible Gram‑positive and some Gram‑negative bacteria on the skin, helping to clear infection and reduce inflammation.

The specific dosing regimen for Inderm is determined by the prescribing clinician based on the severity of the condition, patient age, and treatment area. The prescriber will provide instructions on the amount to apply and frequency of use.

Safety data for topical erythromycin in pregnancy and lactation are limited. Clinicians should weigh potential benefits against unknown risks and consider alternative treatments if safer options are available.

To order Inderm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Inderm provides a topical macrolide option that targets bacterial colonisation and inflammation. Compared with benzoyl peroxide or retinoids, erythromycin has a lower risk of skin dryness but may be less potent for severe acne. It is often used when patients cannot tolerate or have contraindications to other agents.

Inderm should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keeping the product in a cool, dry place helps maintain its stability and potency.

Inderm is applied topically to the affected skin area. The prescriber will advise the amount to use, typically a thin layer, and the frequency—often twice daily—until the infection resolves or as directed.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, and rare cases of drug‑induced liver injury. Patients should seek immediate medical attention if they develop widespread rash, blistering, swelling, or signs of systemic toxicity.

Inderm should not be used by individuals with a known hypersensitivity to erythromycin or other macrolide antibiotics, and it should be avoided on severely broken or infected skin where systemic absorption could be significant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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