Product image of Indigokarmijn Serb (Indigo Carmine) supplied by GNH India

Indigokarmijn Serb

Active Ingredient:
Indigo Carmine
Origin:
EU

Indigokarmijn Serb (Indigo Carmine)

Indigo Carmine, the active ingredient in Indigokarmijn Serb, is a diagnostic dye presented as a sterile aqueous solution for intravenous use. It provides visual staining of urine and tissues to assist in diagnostic and intra‑operative procedures, particularly for urinary tract assessment.

GNH India supplies Indigokarmijn Serb as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Customers benefit from consistent product availability, regulatory compliance, and dedicated technical support throughout the supply chain.

Manufacturer / TM Owner

Serb Sa

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Indications & Clinical Uses

  • Indigokarmijn Serb is used in diagnostic procedures involving the urinary system and imaging studies.
  • Urinary tract visualization: Enables clear coloration of urine to aid assessment during cystoscopy or urography.
  • Intraoperative ureter identification: Stains ureters blue‑green, helping surgeons avoid injury during abdominal or pelvic surgery.
  • Diagnostic imaging enhancement: Provides contrast for imaging techniques that require visual tracer of renal excretion.
  • Renal function assessment: Assists in evaluating renal excretion patterns during functional studies.
  • Bladder assessment: Highlights bladder filling and emptying during urodynamic testing.

How It Works

  • Indigo Carmine is a water‑soluble azo dye that, after intravenous injection, circulates in the plasma and is rapidly filtered by the kidneys. The dye is excreted unchanged in the urine, imparting a blue‑green color that delineates urinary structures. Its affinity for extracellular proteins also allows transient staining of tissues, providing visual contrast during surgical exploration. The coloration persists for a short period, after which normal urine color returns as the dye is cleared.

Side Effects

Indigo Carmine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Transient hypertension: Temporary increase in blood pressure shortly after injection.
  • Nausea: Feeling of sickness or urge to vomit.
  • Flushing: Warmth and redness of the skin.
  • Skin discoloration: Temporary blue‑green tint of skin or mucous membranes.

Serious or Rare Side Effects

  • Anaphylaxis: Severe allergic reaction that can be life‑threatening.
  • Methemoglobinemia: Oxidation of hemoglobin reducing oxygen delivery.
  • Renal impairment: Deterioration of kidney function.

Precautions & Warnings

When using Indigo Carmine, several precautions should be observed to minimize risks.

  • Renal function assessment: Evaluate baseline kidney function before administration.
  • Cardiovascular monitoring: Observe blood pressure and heart rate during and after injection.
  • Allergy history: Confirm no prior hypersensitivity to azo dyes or related compounds.
  • Pregnancy considerations: Use only if clearly needed, as safety data are limited.
  • Concomitant medications: Review drugs that may affect blood pressure or cause methemoglobinemia.
  • Store below 25°C: Keep in original container, protect from light and moisture.

Avoid Interactions

Indigo Carmine can interact with certain medicines; awareness of these interactions helps ensure safe use.

Major Interactions (Avoid)

  • Sympathomimetic agents: May potentiate hypertension caused by the dye.
  • Methemoglobinemia‑inducing drugs: Increase risk of methemoglobinemia (e.g., dapsone, nitrites).

Moderate Interactions (Monitor Closely)

  • Renally excreted drugs: May alter clearance of nephrotoxic agents such as aminoglycosides.
  • Antihypertensive medications: Dye‑induced blood pressure changes may mask drug effects.
  • Diuretics: May affect urine output and dye concentration, influencing visualisation.

Frequently Asked Questions

Indigokarmijn Serb contains Indigo Carmine, a diagnostic dye employed to colour urine and tissues during medical procedures. It is commonly used to visualise the urinary tract, identify ureters intra‑operatively, and enhance contrast in certain imaging studies.

Indigo Carmine is a water‑soluble azo dye that, after intravenous administration, is filtered by the kidneys and excreted unchanged in the urine. The dye imparts a blue‑green colour, providing visual contrast that helps clinicians identify urinary structures and assess renal function.

The appropriate dose of Indigokarmijn Serb is determined by the prescribing healthcare professional based on the specific diagnostic procedure, patient characteristics, and clinical guidelines. No fixed dosing regimen is provided in public literature.

Safety data for Indigo Carmine during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when clearly needed and after a risk‑benefit assessment by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The most common alternative is Methylene Blue, another injectable dye. Indigo Carmine typically provides a more intense blue‑green colour and is excreted rapidly, whereas Methylene Blue may have additional pharmacologic effects such as monoamine‑oxidase inhibition. Choice depends on the specific clinical need and physician preference.

Indigokarmijn Serb should be stored below 25 °C in its original packaging, protected from light and moisture. The solution must be kept in a controlled environment and used before the expiry date indicated on the label.

Indigo Carmine is administered by intravenous injection or infusion under the supervision of qualified medical personnel. The dye is delivered directly into the bloodstream, allowing rapid distribution to the kidneys and subsequent urinary excretion.

Serious adverse reactions include anaphylaxis, severe hypotension, methemoglobinemia, and acute renal impairment. Patients should be monitored closely for signs of allergic response, sudden blood‑pressure changes, or reduced kidney function during and after administration.

Indigo Carmine is contraindicated in individuals with known hypersensitivity to the dye or other azo compounds. Patients with severe renal impairment or a history of severe allergic reactions should avoid its use unless absolutely necessary and under strict medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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