Product image of Indigokarmin Serb (Indigo Carmine) supplied by GNH India

Indigokarmin Serb

Active Ingredient:
Indigo Carmine
Origin:
EU

Indigokarmin Serb (Indigo Carmine)

Indigo Carmine, the active ingredient in Indigokarmin Serb, is a diagnostic dye presented as a solution for injection for intravenous use. It provides coloration for visualisation during diagnostic and surgical procedures in patients requiring imaging of the urinary tract, intra‑operative tissue staining, and ophthalmic contrast.

GNH India supplies Indigokarmin Serb as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Serb Sa

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Indications & Clinical Uses

  • Indigokarmin Serb, a diagnostic dye, is used in procedures that require visual contrast of urinary, surgical, or ocular tissues.
  • Urinary tract imaging: Enables clear visualization of the urinary system during radiographic or endoscopic examinations.
  • Intra‑operative tissue staining: Highlights surgical planes and structures to assist surgeons during operations.
  • Ophthalmic contrast: Provides temporary coloration of ocular tissues for diagnostic procedures such as angiography.

How It Works

  • Indigo Carmine is a water‑soluble triarylmethane dye that, after intravenous administration, distributes rapidly in the plasma and is filtered by the kidneys. The dye binds to plasma proteins and imparts a blue coloration to vascular and urinary structures, allowing clinicians to trace fluid pathways and enhance visual contrast during imaging or surgical observation.

Side Effects

Indigokarmin Serb may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Transient hypotension: temporary drop in blood pressure.
  • Nausea or vomiting: mild gastrointestinal upset.
  • Headache: brief episodes of mild pain.
  • Flushing or warmth: sensation of heat on the skin.
  • Urticaria: mild skin rash or hives.
  • Metallic taste: brief alteration in taste perception.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Methemoglobinemia: abnormal hemoglobin leading to reduced oxygen delivery.
  • Severe hypotension: prolonged low blood pressure with dizziness or fainting.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Acute renal dysfunction: sudden decrease in kidney function.

Precautions & Warnings

  • Before administering Indigokarmin Serb, clinicians should consider several safety measures.
  • Allergy assessment: Verify no known hypersensitivity to indigo carmine or related dyes.
  • Renal function: Evaluate kidney function as the dye is primarily renally excreted.
  • Pregnancy: Use only if clearly needed; limited safety data are available.
  • Concurrent antihypertensives: Monitor blood pressure closely when patients are on vasodilators or beta‑blockers.
  • Dosage adjustment: Adjust volume in patients with compromised cardiovascular status.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Indigo Carmine can interact with certain medications, influencing cardiovascular stability and renal clearance.

Major Interactions (Avoid)

  • Beta‑blockers: May exacerbate dye‑induced hypotension.
  • Calcium channel blockers: Increased risk of severe hypotension.
  • General anesthetics (e.g., propofol): Additive cardiovascular depression.

Moderate Interactions (Monitor Closely)

  • Diuretics: May alter renal elimination of the dye.
  • ACE inhibitors: Monitor for additive blood‑pressure lowering effects.

Frequently Asked Questions

Indigokarmin Serb is a diagnostic dye containing indigo carmine that is administered intravenously to provide visual contrast during urinary tract imaging, intra‑operative tissue staining, and ophthalmic contrast procedures. It helps clinicians see structures more clearly during diagnostic and surgical interventions.

Indigo Carmine is a water‑soluble dye that circulates in the bloodstream after intravenous injection. It binds to plasma proteins and is filtered by the kidneys, imparting a blue coloration to vascular and urinary structures. This visual tracer enables clinicians to track fluid pathways and enhance contrast in imaging or surgical fields.

The exact dose of Indigokarmin Serb is determined by the prescribing clinician based on the specific diagnostic or surgical procedure, patient weight, and clinical condition. Healthcare professionals follow established guidelines and adjust the volume to achieve adequate visual contrast while maintaining safety.

Safety data for indigo carmine in pregnancy and lactation are limited. The product should be used only if clearly needed and after a risk‑benefit assessment by the prescriber. Women who are pregnant or breastfeeding should discuss potential risks with their healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including cold‑chain if required), and import documentation.

Indigo carmine provides a distinct blue coloration and is rapidly cleared by the kidneys, making it useful for short‑duration procedures. Compared with sodium fluorescein, which emits fluorescence, indigo carmine offers visible color contrast without special lighting. Choice of dye depends on the procedure, required imaging modality, and patient tolerance.

Indigokarmin Serb should be stored at 2‑8 °C in a refrigerator, protected from light, and never frozen. The vial must be kept in its original packaging to avoid moisture exposure. Before use, inspect for particulate matter or discoloration; do not shake the solution vigorously.

The product is supplied as a sterile solution for injection and is administered intravenously by a qualified healthcare professional. The injection is typically given as a bolus or slow infusion, depending on the clinical protocol, to achieve the desired level of tissue coloration.

Serious risks include anaphylactic reactions, severe hypotension, methemoglobinemia, cardiac arrhythmias, and acute renal dysfunction. Immediate medical intervention is required if any of these events occur. Monitoring of vital signs during and after administration is essential to detect adverse reactions promptly.

Patients with a known hypersensitivity to indigo carmine or any component of the formulation should not receive the product. Caution is also advised for individuals with severe cardiovascular instability, uncontrolled hypertension, or significant renal impairment, as they may be at higher risk for adverse effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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