Product image of Indio (111in) Ossina (Indium (111in) Oxine) supplied by GNH India

Indio (111in) Ossina

Active Ingredient:
Indium (111in) Oxine
Origin:
EU

Indio (111in) Ossina (Indium (111in) Oxine)

Indium-111 oxine, the active ingredient in Indio (111in) Ossina, is a radiopharmaceutical presented as a sterile solution for intravenous use. It is employed to label white blood cells, enabling nuclear imaging of infection, inflammation and related conditions in adult and pediatric patients.

GNH India supplies Indio (111in) Ossina as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide. The company adheres to EU GMP standards and provides regulatory support for cross‑border distribution, ensuring product integrity and timely delivery.

Manufacturer / TM Owner

Curium Netherlands B.V.

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Indications & Clinical Uses

Indium-111 oxine is used in nuclear medicine to image infection and inflammatory processes.

  • Acute infection: enables detection of bacterial infections by visualizing labeled leukocyte accumulation.
  • Chronic osteomyelitis: assists in localizing bone infection for surgical planning.
  • Prosthetic joint infection: helps differentiate septic from aseptic loosening of implants.
  • Fever of unknown origin: supports identification of occult infectious foci.

How It Works

  • Indium-111 oxine is a lipophilic complex that readily penetrates leukocyte membranes. Inside the cell, the oxine ligand dissociates, allowing the indium‑111 ion to bind intracellular proteins. The labeled leukocytes retain normal migratory function and emit gamma photons, which are detected by gamma cameras to produce high‑resolution images of infection or inflammation sites.

Side Effects

Adverse reactions are generally related to the radiopharmaceutical nature of the product and the intravenous route.

Common Side Effects

  • Injection site pain: mild discomfort at the infusion site.
  • Transient fever: short‑lived rise in body temperature.
  • Nausea: mild queasiness following administration.
  • Headache: occasional mild headache.
  • Flushing: brief skin reddening.
  • Mild hypotension: temporary drop in blood pressure.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Severe hypotension: marked blood pressure decline needing intervention.
  • Radiation‑induced marrow suppression: rare decrease in blood cell production.
  • Severe allergic dermatitis: extensive skin reaction.
  • Acute renal impairment: rare kidney function decline.
  • Persistent infection at injection site: uncommon but serious local infection.

Precautions & Warnings

Careful assessment and monitoring are essential when using Indium-111 oxine.

  • Renal function: evaluate kidney performance as the tracer is renally excreted.
  • Pregnancy: avoid unless the diagnostic benefit outweighs fetal radiation risk.
  • Breastfeeding: discontinue nursing for an appropriate interval after administration.
  • Concurrent radiopharmaceuticals: avoid overlapping studies to prevent cumulative radiation exposure.
  • Allergy history: screen for hypersensitivity to indium or oxine compounds.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Indium-111 oxine may interact with other agents that affect blood cells or radiation exposure.

Major Interactions (Avoid)

  • Chemotherapy agents: can increase marrow toxicity when combined.
  • Other radiopharmaceuticals: additive radiation dose may exceed safety limits.
  • High‑dose steroids: may reduce leukocyte labeling efficiency.

Moderate Interactions (Monitor Closely)

  • Iodinated contrast media: may interfere with imaging interpretation.
  • Anticoagulants: could alter leukocyte function and distribution.
  • Immunosuppressants: may affect the immune response and tracer uptake.

Frequently Asked Questions

Indio (111in) Ossina contains Indium-111 oxine, a radiopharmaceutical used to label white blood cells for nuclear imaging. It helps clinicians locate sites of infection, inflammation, osteomyelitis, prosthetic joint infection, and fever of unknown origin by visualizing the distribution of labeled leukocytes.

Indium-111 oxine penetrates leukocyte membranes and releases the indium‑111 ion, which binds intracellular proteins. The labeled cells retain their natural migration to infection or inflammation sites, and the emitted gamma radiation is captured by a gamma camera, producing diagnostic images of the affected areas.

The administered activity of Indium-111 oxine is determined by the prescribing physician based on patient weight, clinical indication, and imaging protocol. Dosing is individualized and must follow local regulatory and institutional guidelines.

Indium-111 oxine involves ionizing radiation, which can pose risks to a developing fetus. It should be avoided in pregnancy unless the diagnostic benefit clearly outweighs the risk. Breastfeeding mothers should discontinue nursing for a period recommended by the treating physician to prevent radiation exposure to the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Indium-111 oxine is a well‑established leukocyte‑labeling tracer offering high specificity for infection and inflammation. Compared with newer agents such as 99mTc‑HMPAO or 68Ga‑labeled compounds, it provides longer imaging windows due to the 2.8‑day half‑life of indium‑111, but requires more complex preparation and handling.

The product must be stored refrigerated at 2‑8 °C, protected from light, and never frozen or shaken. It should be kept in its original container until use, and any unused portion must be discarded according to local radiopharmaceutical waste regulations.

Indium-111 oxine is supplied as a sterile solution for intravenous injection. After preparation of the labeled leukocyte preparation in a controlled laboratory setting, the radiolabeled cells are re‑infused into the patient through a peripheral or central vein under aseptic conditions.

Serious risks include severe allergic reactions such as anaphylaxis, significant hypotension, and rare radiation‑induced bone‑marrow suppression. Patients should be monitored closely during and after administration, and emergency measures must be readily available to manage any acute adverse events.

Patients with known hypersensitivity to indium or oxine compounds, those with severe renal impairment, pregnant or lactating women (unless absolutely necessary), and individuals who have received other high‑dose radiopharmaceuticals within a short interval should avoid this tracer. Clinical judgment is essential to assess suitability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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