Product image of Indium (111in) Dtpa Curium Netherlands Bv (Pentetic Acid, Indium (111in) Pentetate) supplied by GNH India

Indium (111in) Dtpa Curium Netherlands Bv

Active Ingredient:
Pentetic Acid, Indium (111in) Pentetate
Origin:
EU

Indium (111in) Dtpa Curium Netherlands Bv (Pentetic Acid, Indium (111in) Pentetate)

Indium-111 pentetate, the active ingredient in Indium (111in) Dtpa Curium Netherlands Bv, is a diagnostic radiopharmaceutical presented as a solution for intrathecal use. It enables imaging of cerebrospinal fluid pathways and detection of CSF leaks in patients undergoing neuro‑diagnostic evaluation.

GNH India supplies Indium (111in) Dtpa Curium Netherlands Bv as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Curium Netherlands B.V.

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Indications & Clinical Uses

Indium (111in) Dtpa is used in diagnostic imaging of the cerebrospinal fluid system and related conditions.

  • Cerebrospinal fluid pathway imaging: provides high‑resolution visualization of CSF flow dynamics.
  • CSF leak detection: localises sites of spinal or cranial cerebrospinal fluid leakage.
  • Ventricular shunt assessment: evaluates patency and function of implanted CSF shunt devices.

How It Works

  • Indium‑111 pentetate is a chelated radiotracer where the DTPA ligand binds the gamma‑emitting isotope Indium‑111. After intrathecal injection, the complex distributes uniformly within the cerebrospinal fluid, allowing gamma camera detection of its emissions. The resulting images map CSF pathways and reveal abnormal leaks or blockages, supporting diagnostic decision‑making.

Side Effects

Adverse reactions may occur following intrathecal administration of Indium‑111 pentetate.

Common Side Effects

  • Headache: mild to moderate discomfort after the procedure.
  • Nausea: transient feeling of queasiness.
  • Transient back pain: localized at the injection site.
  • Mild fever: low‑grade temperature elevation.
  • Localized irritation: mild redness or bruising at puncture site.

Serious or Rare Side Effects

  • Allergic reaction: rash, urticaria, or anaphylaxis.
  • Neurotoxicity: rare neurological symptoms such as seizures.
  • Severe infection: meningitis or spinal infection.
  • Radiation‑induced tissue injury: uncommon but possible with high cumulative doses.
  • Hemorrhage: spinal or epidural bleeding at injection site.

Precautions & Warnings

Prior to using Indium (111in) Dtpa, clinicians should consider several safety measures.

  • Pregnancy: avoid unless essential, as fetal effects are unknown.
  • Breastfeeding: discontinue nursing or assess risk‑benefit, due to possible radiation exposure.
  • Renal impairment: monitor renal function, as clearance may be altered.
  • Allergy history: verify no known hypersensitivity to DTPA or indium compounds.
  • Radiation exposure: limit repeat studies and adhere to ALARA principles.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Indium (111in) Dtpa may interact with other agents that affect imaging or CSF dynamics.

Major Interactions (Avoid)

  • Concurrent radiopharmaceuticals: overlapping gamma emissions can compromise image quality.
  • High‑dose iodinated contrast: may interfere with radionuclide detection.

Moderate Interactions (Monitor Closely)

  • Medications altering CSF flow (e.g., acetazolamide): may affect tracer distribution.
  • Anticoagulants: increase risk of spinal puncture bleeding.
  • Intrathecal antibiotics or steroids: could modify tracer kinetics.
  • Renal‑clearing drugs: monitor for altered systemic clearance.

Frequently Asked Questions

Indium (111in) Dtpa is a diagnostic radiopharmaceutical used to image cerebrospinal fluid pathways and to locate cerebrospinal fluid leaks. It is administered intrathecally, allowing gamma camera systems to capture detailed images that assist neurologists and radiologists in diagnosing conditions such as spinal leaks or shunt malfunctions.

Indium‑111 pentetate consists of the chelating agent DTPA bound to the gamma‑emitting isotope Indium‑111. After intrathecal injection, the complex mixes with cerebrospinal fluid and travels throughout the CSF spaces. The emitted gamma photons are detected by imaging equipment, producing visual maps of CSF flow and revealing any abnormal leaks or blockages.

The specific dose of Indium (111in) Dtpa is determined by the prescribing physician based on the patient’s age, weight, clinical indication, and imaging protocol. Dosing is individualized and should follow the relevant nuclear medicine guidelines and institutional policies.

Safety data for Indium (111in) Dtpa in pregnancy and lactation are limited. It should be avoided unless the diagnostic benefit outweighs potential risks to the fetus or infant. If use is essential, a risk‑benefit assessment by the treating physician is required, and appropriate precautions should be taken.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Indium (111in) Dtpa offers high‑resolution gamma imaging and a relatively long half‑life, allowing extended imaging windows compared with short‑lived agents like Technetium‑99m DTPA. It provides clearer delineation of CSF pathways but involves higher radiation exposure, so selection depends on clinical needs, availability, and institutional protocols.

The product should be stored at 2‑8 °C in its original container, protected from light, and must not be frozen or shaken. Handling requires radiation safety measures, including shielding, use of lead containers, and adherence to local radiopharmacy regulations to protect personnel and patients.

Indium (111in) Dtpa is administered by a trained healthcare professional via intrathecal injection, typically through a lumbar puncture. The procedure is performed under sterile conditions, and the patient is monitored for immediate adverse reactions before proceeding with imaging.

Serious risks include allergic reactions ranging from rash to anaphylaxis, rare neurotoxic events such as seizures, infection at the injection site (including meningitis), spinal hemorrhage, and radiation‑induced tissue injury. Prompt recognition and management of these events are essential.

Patients with known hypersensitivity to DTPA or indium compounds, those with active spinal infections, uncontrolled coagulopathy, or severe pregnancy should avoid the agent unless the diagnostic benefit clearly outweighs the risks. Clinical judgment is required for each individual case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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