Product image of Indium (111in) Dtpa Curium Netherlands Bv (Pentetic Acid, Indium (111in) Pentetate) supplied by GNH India

Indium (111in) Dtpa Curium Netherlands Bv

Active Ingredient:
Pentetic Acid, Indium (111in) Pentetate
Origin:
EU

Indium (111in) Dtpa Curium Netherlands Bv (Pentetic Acid, Indium (111in) Pentetate)

Indium-111 pentetate, the active ingredient in Indium (111in) Dtpa Curium Netherlands Bv, is a radiopharmaceutical presented as a radiopharmaceutical for intrathecal use. It is employed to visualize cerebrospinal fluid pathways and detect leaks in patients undergoing diagnostic imaging.
GNH India supplies Indium (111in) Dtpa Curium Netherlands Bv as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Curium Netherlands B.V.

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Indications & Clinical Uses

Indium (111in) Dtpa is used in diagnostic imaging of the cerebrospinal fluid system and related conditions.

  • Cerebrospinal fluid imaging: visualizes CSF flow and anatomy to assess normal and abnormal pathways.
  • Detection of CSF leaks: identifies sites of leakage by highlighting tracer extravasation.
  • Intrathecal radionuclide cisternography: provides functional imaging of CSF dynamics for clinical evaluation.

How It Works

  • Indium‑111 is chelated to pentetate, forming a stable complex that remains within the cerebrospinal fluid after intrathecal injection. The complex emits gamma photons detectable by scintigraphic cameras, allowing real‑time mapping of CSF distribution and identification of abnormal collections or leaks without altering physiological flow.

Side Effects

Adverse reactions may occur following intrathecal administration of Indium (111in) Dtpa.

Common Side Effects

  • Headache: mild to moderate, often transient.
  • Nausea or vomiting: usually short‑lived.
  • Back pain at injection site: mild discomfort.
  • Transient flushing or warmth sensation.
  • Mild fever or chills.
  • Injection site discomfort or bruising.

Serious or Rare Side Effects

  • Allergic reaction or anaphylaxis: signs include rash, swelling, difficulty breathing.
  • Severe headache or meningismus: may indicate irritation of meninges.
  • Radiation‑induced tissue injury: rare, may affect neural structures.
  • Infection or meningitis: due to breach of sterile technique.
  • Significant hypotension or cardiovascular instability.
  • Persistent neurological deficits: extremely uncommon.

Precautions & Warnings

When using Indium (111in) Dtpa, clinicians should observe several safety measures.

  • Pregnancy: avoid unless benefits outweigh potential fetal radiation exposure.
  • Breastfeeding: discontinue nursing for an appropriate period after administration.
  • Renal impairment: consider reduced clearance of radiotracer and adjust monitoring.
  • Prior allergic reactions: assess risk of hypersensitivity to radiopharmaceuticals.
  • Radiation safety: limit exposure to staff and other patients, follow institutional protocols.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Indium (111in) Dtpa may interact with other agents that affect imaging quality or radiation exposure.

Major Interactions (Avoid)

  • Concurrent intrathecal contrast agents: can alter tracer distribution and imaging interpretation.
  • Therapeutic radionuclide therapy: cumulative radiation dose may exceed safety limits.
  • High‑dose chemotherapeutic agents affecting bone marrow: increase risk of radiation‑induced cytopenia.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: may raise risk of spinal bleeding after intrathecal injection.
  • Corticosteroids: can mask inflammatory responses to the tracer.
  • Diuretics: may modify CSF dynamics, influencing tracer clearance.
  • Beta‑blockers: potential impact on hemodynamic response during imaging.
  • NSAIDs: may affect pain perception related to injection site.

Frequently Asked Questions

Indium (111in) Dtpa is a radiopharmaceutical used primarily for diagnostic imaging of the cerebrospinal fluid system. It helps visualize CSF flow, detect leaks, and perform intrathecal radionuclide cisternography, providing clinicians with functional information about CSF dynamics.

The drug consists of indium‑111 chelated to pentetate, forming a stable complex that remains in the cerebrospinal fluid after intrathecal injection. Indium‑111 emits gamma radiation that can be captured by scintigraphic cameras, creating detailed images of CSF pathways and any abnormal tracer accumulation.

The specific activity and volume of Indium (111in) Dtpa are determined by the prescribing physician based on the patient’s age, weight, and the imaging protocol. Dosing is individualized and should follow the radiopharmacy’s preparation guidelines and local regulatory requirements.

Safety data are limited, and the radiopharmaceutical involves ionizing radiation. It should be avoided in pregnant or nursing patients unless the diagnostic benefit clearly outweighs the potential risk to the fetus or infant. Consultation with a radiation safety specialist is recommended.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Indium‑111 pentetate offers high‑resolution gamma emission suitable for long‑duration imaging, allowing detailed assessment of CSF flow. Compared with iodine‑based contrast agents, it provides functional rather than purely anatomical information and involves lower allergic risk, though it requires specialized radiation handling and imaging equipment.

The product should be stored at ambient temperature, protected from light and moisture, and kept in its original sealed container. Handling must follow radiopharmacy guidelines, including use of shielding, proper labeling, and disposal of radioactive waste according to local regulations.

Indium (111in) Dtpa is administered by a trained healthcare professional via a sterile intrathecal injection into the lumbar subarachnoid space. The procedure is performed under aseptic conditions, and the patient is monitored for immediate adverse reactions before proceeding with imaging.

Serious risks include allergic reactions or anaphylaxis, radiation‑induced tissue injury, infection or meningitis from the injection site, and severe headache or neurological symptoms indicating irritation of the meninges. Prompt medical evaluation is essential if any of these occur.

Patients with known hypersensitivity to indium‑111, pentetate, or any component of the formulation should avoid the drug. It is also contraindicated in individuals with active central nervous system infections, uncontrolled coagulopathy, or when pregnancy or breastfeeding cannot be ruled out without appropriate risk assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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