Product image of Indium (In-111) Chloride Curium (Indium (111in)) supplied by GNH India

Indium (In-111) Chloride Curium

Active Ingredient:
Indium (111in)
Origin:
EU

Indium (In-111) Chloride Curium (Indium (111in))

Indium-111, the active ingredient in Indium (In-111) Chloride Curium, is a radiopharmaceutical presented as a solution for injection for intravenous use. It is employed to image tumors, sites of inflammation, infection and for leukocyte labeling in scintigraphy.

GNH India supplies Indium (In-111) Chloride Curium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, transplant centres and clinics worldwide.

Manufacturer / TM Owner

Curium Belgium Bv

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Indications & Clinical Uses

  • Indium-111 chloride is used in nuclear medicine to visualize abnormal cellular activity in oncologic and inflammatory conditions.
  • Tumor imaging: provides high‑resolution images of malignant lesions for staging and treatment planning.
  • Inflammation detection: highlights areas of active inflammation for diagnostic clarification.
  • Infection localization: identifies focal infections to guide antimicrobial therapy.
  • Leukocyte labeling for scintigraphy: labels white blood cells to locate sites of infection or inflammation.

How It Works

  • Indium-111 chloride emits gamma photons that are detected by a gamma camera. After intravenous injection, the radionuclide binds to plasma proteins and preferentially accumulates in tissues with increased vascular permeability or active leukocyte recruitment, allowing precise anatomical localization of tumors, inflammatory foci, or infectious sites.

Side Effects

Adverse reactions are generally mild but can occur after intravenous administration.

Common Side Effects

  • Injection site pain or erythema
  • Nausea or mild vomiting
  • Transient headache
  • Flushing or warmth sensation
  • Metallic taste in the mouth
  • Temporary mild hypotension

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction
  • Radiation‑induced skin injury at the injection site
  • Severe hypotension or cardiovascular collapse
  • Arrhythmias related to radiation exposure
  • Bone marrow suppression with high cumulative doses
  • Organ toxicity in patients with impaired clearance

Precautions & Warnings

Use of Indium-111 chloride requires careful consideration of patient safety and handling.

  • Pregnancy: safety unknown; avoid unless diagnostic benefit outweighs risk.
  • Breastfeeding: unknown; consider discontinuing breastfeeding during and after administration.
  • Renal impairment: monitor renal function as excretion may be reduced.
  • Concurrent radiopharmaceuticals: avoid overlapping scans to prevent excess radiation dose.
  • Radiation safety: follow ALARA principles for staff and patient protection.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Indium-111 chloride may interact with other agents that affect radiation exposure or biodistribution.

Major Interactions (Avoid)

  • Other radiopharmaceuticals: cumulative radiation dose may exceed safety limits.
  • Myelosuppressive chemotherapy: increased risk of hematologic toxicity.

Moderate Interactions (Monitor Closely)

  • Iodinated contrast agents used in CT: may alter image interpretation.
  • Drugs altering plasma protein binding: could change tracer distribution.
  • Antihistamines: may mask early signs of an allergic reaction.
  • Beta‑blockers: may affect cardiovascular response to the tracer.

Frequently Asked Questions

Indium (In-111) Chloride Curium is a radiopharmaceutical used in nuclear medicine to image malignant tumors, detect sites of inflammation, localize infections, and label leukocytes for scintigraphic studies. The gamma emissions from Indium‑111 allow high‑resolution visualization with a gamma camera, aiding diagnosis and treatment planning.

After intravenous injection, Indium‑111 binds to plasma proteins and accumulates in tissues with increased vascular permeability or active immune cell recruitment. The radionuclide emits gamma photons that are captured by a gamma camera, producing detailed images of the targeted area such as tumors, inflamed tissue, or infection sites.

The administered activity of Indium (In-111) Chloride Curium is determined by the prescribing physician based on the specific diagnostic indication, patient weight, and imaging protocol. Dosage is individualized and should follow the relevant nuclear medicine guidelines and local regulatory requirements.

Safety data for Indium (In-111) Chloride Curium in pregnancy and lactation are limited. It is generally avoided unless the diagnostic benefit outweighs potential fetal or infant radiation exposure. If administered, a risk‑benefit assessment should be performed by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including cold‑chain if needed) and assist with import documentation.

Indium‑111 offers a longer half‑life (≈2.8 days) and gamma emission energies suitable for high‑resolution imaging, making it advantageous for delayed imaging and leukocyte labeling. Compared with technetium‑99m agents, it provides extended imaging windows but involves higher radiation dose, requiring careful patient selection.

The product should be stored refrigerated at 2‑8 °C, protected from light, and never frozen or shaken. It must be kept in its original container until use and handled by trained personnel using appropriate radiation safety measures.

Indium (In-111) Chloride Curium is supplied as a sterile solution for injection and is administered intravenously by a qualified healthcare professional. The injection is performed under aseptic conditions, followed by the appropriate imaging protocol.

Serious risks include severe allergic reactions (anaphylaxis), radiation‑induced skin injury at the injection site, significant hypotension, arrhythmias, and bone‑marrow suppression with high cumulative doses. Immediate medical attention is required if any severe reaction occurs.

Patients with known hypersensitivity to indium compounds, those who are pregnant or breastfeeding (unless essential), individuals with severe renal impairment without appropriate monitoring, and patients who have recently received other radiopharmaceuticals that could cause excessive radiation exposure should avoid this agent.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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