Product image of Indium (In-111)klorid Curium Netherlands (Indium (111in) Chloride) supplied by GNH India

Indium (In-111)klorid Curium Netherlands

Active Ingredient:
Indium (111in) Chloride
Origin:
EU

Indium (In-111)klorid Curium Netherlands (Indium (111in) Chloride)

Indium-111 chloride, the active ingredient in Indium (In-111)klorid Curium Netherlands, is a radiopharmaceutical presented as a radiopharmaceutical for intravenous use. It is employed as a diagnostic imaging agent that emits detectable gamma radiation for nuclear medicine procedures. GNH India supplies Indium (In-111)klorid Curium Netherlands as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Curium Netherlands B.V.

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Indications & Clinical Uses

Indium-111 chloride is used in nuclear medicine for imaging applications that require targeted gamma‑ray emission.

  • Lymphoscintigraphy: visualizes lymphatic drainage pathways and sentinel lymph nodes.
  • Infection imaging: localizes sites of infection or inflammation by labeling leukocytes.
  • Tumor targeting: assists in identifying tumor sites when bound to specific antibodies or peptides.
  • Bone marrow imaging: evaluates marrow activity and distribution.
  • Cardiac imaging: assesses myocardial perfusion in selected protocols.

How It Works

  • Indium-111 chloride emits gamma photons after intravenous administration. The isotope binds to labeled cells, antibodies, or compounds that target specific tissues, allowing external gamma cameras to detect and construct images of the distribution of the radiolabeled agent within the body, thereby providing functional diagnostic information.

Side Effects

Indium-111 chloride may cause reactions related to its radioactive nature and intravenous administration.

Common Side Effects

  • Injection site pain: mild discomfort at the site of administration.
  • Nausea: transient feeling of queasiness.
  • Transient flushing: brief warmth or redness.
  • Mild headache: short‑lasting headache.
  • Low‑grade fever: temporary elevation of body temperature.

Serious or Rare Side Effects

  • Allergic reaction: rash, urticaria, or anaphylaxis.
  • Radiation‑induced tissue injury: localized damage at high cumulative doses.
  • Hematologic changes: temporary reduction in blood cell counts.
  • Renal impairment: rare impact on kidney function.
  • Severe hypotension: sudden drop in blood pressure post‑injection.

Precautions & Warnings

When handling Indium-111 chloride, follow standard radiopharmacy safety protocols.

  • Radiation protection: use shielding and limit exposure time.
  • Patient assessment: evaluate for known hypersensitivity to radiopharmaceuticals.
  • Pregnancy consideration: avoid use unless benefits outweigh potential fetal radiation risk.
  • Breastfeeding: discontinue breastfeeding if administered to lactating patients.
  • Renal function: assess kidney function before administration.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Indium-111 chloride may interact with substances that affect radiation distribution or clearance.

Major Interactions (Avoid)

  • Chelating agents: can bind the isotope and alter biodistribution.
  • High‑dose steroids: may reduce inflammatory cell labeling.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: may increase risk of bleeding at injection site.
  • Renal‑clearing drugs: could affect renal excretion of the radiotracer.
  • Contrast agents: may interfere with imaging interpretation.
  • Other radiopharmaceuticals: cumulative radiation dose considerations.
  • Immunosuppressants: may modify immune cell labeling efficiency.

Frequently Asked Questions

Indium-111 chloride is a radiopharmaceutical used in nuclear medicine to label cells, antibodies or peptides, enabling gamma‑camera imaging of lymphatic pathways, infection sites, tumors, bone marrow and certain cardiac studies.

After intravenous injection, the indium‑111 isotope emits gamma radiation that is detected by imaging equipment. The compound binds to targeted biological structures, allowing clinicians to visualize the distribution of the labeled material within the body.

The administered activity of Indium-111 chloride is determined by the prescribing physician based on the specific diagnostic procedure, patient characteristics and regulatory guidelines. Dosage is not standardized and must be individualized.

The safety of Indium-111 chloride in pregnancy and lactation has not been fully established. It should be used only if the diagnostic benefit outweighs potential radiation risks to the fetus or infant, and breastfeeding may need to be paused after administration.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Indium-111 chloride offers a longer half‑life (≈2.8 days) compared with technetium‑99m agents, allowing delayed imaging and cell labeling. It provides high‑resolution gamma emission but involves higher radiation exposure, making it suitable for specific applications where longer imaging windows are needed.

Indium-111 chloride must be stored refrigerated at 2‑8 °C, protected from light, and kept in its original container. It should not be frozen or shaken, and handling must follow radiopharmacy safety procedures to limit radiation exposure.

The product is administered intravenously by a qualified healthcare professional. The injection is performed under aseptic conditions, and the patient is monitored for any immediate adverse reactions following administration.

Serious risks include allergic reactions such as anaphylaxis, radiation‑induced tissue injury at high cumulative doses, and rare hematologic changes. Prompt medical attention is required if severe symptoms develop.

Patients with known hypersensitivity to indium‑111 compounds, those who are pregnant unless essential, and individuals with severe renal impairment or uncontrolled infections should avoid this radiopharmaceutical unless a clear clinical benefit is established.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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