Product image of Indium (In-111)klorid Curiumpharma (Indium (111in)) supplied by GNH India

Indium (In-111)klorid Curiumpharma

Active Ingredient:
Indium (111in)
Origin:
EU

Indium (In-111)klorid Curiumpharma (Indium (111in))

Indium-111 chloride, the active ingredient in Indium (In-111)klorid Curiumpharma, is a radiopharmaceutical presented as an injectable solution for intravenous use. It is employed to visualize infection, inflammation, tumors and bone marrow activity in patients undergoing diagnostic imaging, and helps clinicians assess disease distribution and treatment response.

GNH India supplies Indium (In-111)klorid Curiumpharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and imaging centres worldwide, with a focus on quality assurance and regulatory compliance. The company ensures traceability and adherence to EU pharmacopeial standards.

Manufacturer / TM Owner

Curium Netherlands B.V.

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Indications & Clinical Uses

Indium-111 chloride is used in nuclear medicine to image infectious, inflammatory and neoplastic processes.

  • Infection and inflammation imaging: enables visualization of infectious foci and inflammatory lesions, aiding diagnosis and treatment planning.
  • Tumor localization: highlights malignant tissue uptake, supporting tumor detection, staging and therapeutic monitoring.
  • Bone marrow imaging: delineates marrow activity, useful for assessing hematopoietic disorders and transplant engraftment.

How It Works

  • Indium-111 chloride emits gamma photons that are detected by gamma‑camera equipment. After intravenous injection, the isotope distributes according to physiological pathways and binds to specific cellular or tissue targets, such as sites of inflammation, tumor cells, or active bone marrow. The emitted radiation provides high‑resolution images that reflect the biological processes occurring in the targeted regions.

Side Effects

Indium-111 chloride may be associated with the following adverse reactions, which are generally related to the radiopharmaceutical nature and the intravenous administration.

Common Side Effects

  • Nausea: mild, transient feeling of stomach upset.
  • Flushing: temporary redness and warmth of the skin.
  • Headache: mild to moderate discomfort.
  • Warmth at injection site: brief sensation of heat.
  • Transient hypotension: short‑lasting drop in blood pressure.
  • Mild allergic reaction: rash or itching.

Serious or Rare Side Effects

  • Severe allergic reaction or anaphylaxis: potentially life‑threatening.
  • Radiation‑induced tissue injury: damage to organs from radiation exposure.
  • Severe hypotension: prolonged low blood pressure.
  • Hemolysis: breakdown of red blood cells.
  • Bone marrow suppression: reduced blood cell production.
  • Nephrotoxicity: impairment of kidney function.

Precautions & Warnings

When using Indium-111 chloride, several safety considerations should be observed.

  • Pregnancy: avoid unless the diagnostic benefit outweighs potential fetal risk.
  • Breastfeeding: discontinue nursing or assess risk before administration.
  • Renal function: evaluate kidney performance as the agent is renally excreted.
  • Allergy: confirm no known hypersensitivity to indium compounds.
  • Radiation exposure: limit use to essential diagnostic procedures.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Indium-111 chloride can interact with other agents; awareness of major and moderate interactions helps ensure patient safety.

Major Interactions (Avoid)

  • Concurrent radiopharmaceuticals: additive radiation dose may exceed safety limits.
  • Chemotherapeutic agents affecting bone marrow: increased risk of marrow suppression.
  • High‑dose steroids: may alter biodistribution and imaging accuracy.

Moderate Interactions (Monitor Closely)

  • Iodinated contrast agents: may interfere with image interpretation.
  • Beta‑blockers: can mask hypotensive reactions.
  • Anticoagulants: may increase bleeding risk at the injection site.

Frequently Asked Questions

Indium-111 chloride is a radiopharmaceutical used in nuclear medicine to produce gamma‑camera images that help detect and evaluate infection, inflammation, malignant tumors, and bone marrow activity. It provides clinicians with functional information that complements anatomical imaging, supporting diagnosis, disease staging, and treatment monitoring.

The isotope indium‑111 emits gamma radiation that can be captured by a gamma camera. After intravenous injection, it circulates and accumulates in tissues based on physiological processes such as inflammation, tumor metabolism, or marrow activity. The emitted photons generate images that reflect the distribution of the tracer within the body.

The prescribed activity of Indium-111 chloride is determined by the treating physician or nuclear medicine specialist. Dose selection depends on the specific clinical indication, patient size, and the imaging protocol required. No fixed dose is provided here; the prescriber sets the appropriate amount.

Safety data for Indium-111 chloride in pregnancy and lactation are limited. It should only be used when the potential diagnostic benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Indium-111 chloride, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and the necessary import documentation.

Compared with technetium‑99m agents, Indium-111 provides longer‑lasting gamma emission, allowing delayed imaging and better lesion contrast in certain infections and tumors. Unlike FDG‑PET, it does not require a cyclotron and is suited for specific inflammatory and bone‑marrow studies, though PET tracers often offer higher resolution for metabolic imaging.

Indium-111 chloride must be stored refrigerated at 2‑8 °C, protected from light, and kept in its original shielding container. It should not be frozen or shaken, and handling must follow radiation safety guidelines to protect personnel and maintain product integrity.

The product is administered by intravenous injection performed by qualified nuclear medicine or radiology personnel. The injection is usually performed in a controlled environment, such as a nuclear medicine suite, and followed by imaging at predetermined time points based on the clinical protocol.

The most serious risks include severe allergic reactions (anaphylaxis), radiation‑induced tissue injury, significant hypotension, bone‑marrow suppression, and hemolysis. Prompt recognition and management of these events are essential, and patients should be monitored during and after administration.

Individuals with a known hypersensitivity to indium compounds, pregnant women (unless absolutely necessary), nursing mothers (unless benefits outweigh risks), and patients with severe renal impairment should generally avoid this agent. The prescribing clinician must evaluate each case to determine suitability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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