Product image of Indium (In111) Chloride Curium Netherlands (Indium (111in)) supplied by GNH India

Indium (In111) Chloride Curium Netherlands

Active Ingredient:
Indium (111in)
Origin:
EU

Indium (In111) Chloride Curium Netherlands (Indium (111in))

Indium-111 chloride, the active ingredient in Indium (In111) Chloride Curium Netherlands, is a radiopharmaceutical presented as a solution for injection for intravenous use. It localizes in target tissues to enable scintigraphic imaging of infection, inflammation, tumors, or bone marrow activity in patients.

GNH India supplies Indium (In111) Chloride Curium Netherlands as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Curium Netherlands B.V.

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Indications & Clinical Uses

Indium‑111 chloride is used in nuclear medicine to visualize pathological processes involving infection, inflammation, and malignancy.

  • Infection and inflammation: Enables precise localization of infectious foci and inflammatory lesions for diagnostic clarification.
  • Tumor imaging and staging: Provides high‑resolution gamma images to assess tumor presence, extent, and metastatic spread.
  • Bone marrow and leukocyte imaging: Labels autologous leukocytes to evaluate bone‑marrow activity and detect occult infections.

How It Works

  • Indium‑111 chloride emits gamma photons that are detected by scintigraphic cameras. After intravenous injection, the radionuclide binds to plasma proteins and is taken up by leukocytes or accumulates in areas of increased vascular permeability, allowing visualization of infection, inflammation, tumor tissue, or bone‑marrow activity based on differential uptake patterns.

Side Effects

Adverse reactions are generally related to the radiopharmaceutical nature and the injection procedure.

Common Side Effects

  • Mild injection site pain or erythema
  • Transient nausea or vomiting
  • Temporary headache or dizziness
  • Low‑grade fever
  • Mild fatigue
  • Brief flushing sensation

Serious or Rare Side Effects

  • Radiation‑induced tissue injury at the injection site
  • Severe allergic reaction (anaphylaxis)
  • Significant hypotension or cardiovascular collapse
  • Hematologic toxicity in high cumulative doses
  • Organ‑specific radiation damage (e.g., renal)
  • Unexplained persistent fever or infection signs

Precautions & Warnings

Use of Indium‑111 chloride requires careful consideration of radiation safety and patient factors.

  • Radiation exposure: Minimize staff exposure and follow local radiation protection guidelines.
  • Pregnancy: Avoid use unless clearly justified, as fetal radiation risk is unknown.
  • Breastfeeding: Discontinue breastfeeding for an appropriate period after administration.
  • Renal impairment: Assess kidney function, as excretion may be altered.
  • Known hypersensitivity: Do not administer to patients with prior severe reactions to radiopharmaceuticals.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Indium‑111 chloride may interact with other agents that affect radiation dose or biodistribution.

Major Interactions (Avoid)

  • Concurrent administration of other gamma‑emitting radiopharmaceuticals that increase cumulative radiation exposure.
  • Strong chelating agents (e.g., EDTA) that may bind the radionuclide and alter distribution.
  • High‑dose steroids that could suppress leukocyte migration and reduce imaging accuracy.

Moderate Interactions (Monitor Closely)

  • Colony‑stimulating factors that may increase bone‑marrow uptake.
  • Iodinated contrast media used shortly before or after injection, potentially affecting image quality.
  • Anticoagulants that could increase risk of bleeding at the injection site.

Frequently Asked Questions

Indium (In111) Chloride is a diagnostic radiopharmaceutical used in nuclear medicine to image sites of infection, inflammation, tumor tissue, and bone‑marrow activity. After intravenous injection, the gamma‑emitting radionuclide localizes in target areas, allowing clinicians to obtain high‑resolution scintigraphic images for accurate diagnosis and disease staging.

Indium‑111 chloride emits gamma photons that are detected by a gamma camera. Once injected, it binds to plasma proteins and is taken up by circulating leukocytes or accumulates in tissues with increased vascular permeability. This selective localization creates a radiation signal that highlights pathological sites such as infections, inflammatory lesions, or tumors.

The administered activity of Indium (In111) Chloride is determined by the prescribing physician based on the specific diagnostic indication, patient weight, and imaging protocol. Dosage is individualized and must follow local regulatory and radiation safety guidelines; it is not a fixed over‑the‑counter amount.

The safety of Indium (In111) Chloride in pregnancy and lactation has not been established. Because it involves ionizing radiation, it should be avoided unless the diagnostic benefit clearly outweighs the potential fetal or infant risk. Breastfeeding mothers should discontinue nursing for an appropriate period after administration, as advised by a radiation safety specialist.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After receiving the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Indium‑111 chloride offers a relatively long half‑life (≈2.8 days) and gamma emissions suitable for high‑resolution imaging, making it advantageous for delayed imaging of infection or leukocyte labeling. Compared with technetium‑99m agents, it provides later time‑point imaging but involves higher radiation dose. Choice of agent depends on the clinical question, required imaging window, and availability.

Indium (In111) Chloride should be stored at 2‑8 °C in its original container, protected from light, and must not be frozen or shaken. The product is supplied in a shielded container to reduce radiation exposure. Follow local radiation safety and pharmacy handling protocols when preparing and administering the dose.

The radiopharmaceutical is administered intravenously as a sterile solution for injection. The prescribed activity is drawn into a shielded syringe and injected under aseptic conditions. After injection, the patient may be monitored briefly for any immediate reactions before proceeding with the planned imaging procedure.

Serious risks include radiation‑induced tissue injury, severe allergic reactions (anaphylaxis), significant hypotension, and potential hematologic toxicity with high cumulative doses. Patients should be screened for hypersensitivity, and radiation protection measures must be observed to minimize exposure to staff and surrounding individuals.

Indium (In111) Chloride is contraindicated in patients with known severe hypersensitivity to the product or its components, in pregnant women unless absolutely necessary, and in breastfeeding mothers who cannot discontinue nursing for the recommended period. Caution is also advised for individuals with severe renal impairment or those receiving conflicting radiopharmaceuticals.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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