Product image of Indium (In111) Dtpa Curium Netherlands (Pentetic Acid, Indium (111in) Pentetate) supplied by GNH India

Indium (In111) Dtpa Curium Netherlands

Active Ingredient:
Pentetic Acid, Indium (111in) Pentetate
Origin:
EU

Indium (In111) Dtpa Curium Netherlands (Pentetic Acid, Indium (111in) Pentetate)

Indium-111 DTPA, the active ingredient in Indium (In111) Dtpa Curium Netherlands, is a radiopharmaceutical presented as a diagnostic agent for intrathecal use. It enables imaging of cerebrospinal fluid pathways and is employed in patients requiring evaluation of CSF leaks or shunt patency.

GNH India supplies Indium (In111) Dtpa Curium Netherlands as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Curium Netherlands B.V.

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Indications & Clinical Uses

Indium-111 DTPA is used in diagnostic procedures that assess cerebrospinal fluid dynamics and related complications.

  • Cerebrospinal fluid imaging: visualizes CSF flow and anatomy to assess normal and pathological conditions.
  • Detection of CSF leaks: identifies sites of cerebrospinal fluid leakage for diagnostic clarification.
  • Evaluation of ventricular shunt patency: confirms functional status of implanted shunt systems.

How It Works

  • Indium-111 DTPA is a chelated indium‑111 radioisotope that emits gamma photons. After intrathecal injection, the complex distributes uniformly within the cerebrospinal fluid, allowing external gamma‑camera detection and high‑resolution imaging of CSF pathways, leaks, and shunt function.

Side Effects

Adverse reactions may occur following intrathecal administration of Indium-111 DTPA.

Common Side Effects

  • Headache: mild to moderate discomfort after lumbar puncture.
  • Nausea: transient feeling of queasiness.
  • Lumbar puncture site pain: localized soreness.
  • Transient fever: low‑grade temperature rise.
  • Mild back pain: short‑lasting muscular ache.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, or swelling.
  • Anaphylaxis: severe, potentially life‑threatening hypersensitivity.
  • Radiation‑induced myelopathy: rare spinal cord injury.
  • Severe infection: meningitis or epidural abscess.
  • Seizures: neurological events requiring immediate care.
  • Severe headache with neurological signs: indicates possible intracranial pressure changes.

Precautions & Warnings

Careful consideration of patient factors and handling procedures is essential when using Indium-111 DTPA.

  • Pregnancy: unknown risk; avoid unless clearly justified.
  • Breastfeeding: unknown safety; discontinue nursing if administered.
  • Radiation safety: limit exposure to staff and family, follow local guidelines.
  • Renal impairment: monitor because clearance occurs via kidneys.
  • Allergic history: assess prior reactions to radiopharmaceuticals.
  • Store at ambient temperature below 25°C: keep in original shielding container, protect from light and moisture.

Avoid Interactions

Potential drug interactions should be evaluated before administration of Indium-111 DTPA.

Major Interactions (Avoid)

  • Concurrent radiopharmaceuticals with overlapping gamma emissions: may compromise image quality.
  • Medications that markedly increase CSF production: can alter tracer distribution.
  • High‑dose iodinated contrast agents: may interfere with gamma detection.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: increase risk of bleeding from lumbar puncture.
  • Sedatives or analgesics: may mask procedural discomfort.
  • Diuretics: can affect CSF dynamics and tracer clearance.

Frequently Asked Questions

Indium-111 DTPA is a radiopharmaceutical used to image cerebrospinal fluid pathways. It helps clinicians detect CSF leaks, evaluate the patency of ventricular shunts, and assess overall CSF flow dynamics during diagnostic imaging procedures.

The compound contains the radioactive isotope indium‑111 chelated to DTPA. After intrathecal injection, it distributes throughout the cerebrospinal fluid and emits gamma photons that are captured by a gamma camera, producing detailed images of CSF spaces.

The administered activity is determined by the prescribing physician based on the patient’s age, weight, and the specific imaging protocol. Dosage is individualized and should follow local regulatory and institutional guidelines.

The safety profile in pregnancy and lactation is not well established. Use is generally avoided unless the diagnostic benefit outweighs potential risks, and alternative imaging methods should be considered when possible.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Indium-111 DTPA offers high‑resolution gamma imaging and a relatively long half‑life, allowing extended imaging windows compared with short‑lived agents like technetium‑99m. It is specifically approved for intrathecal use, whereas some alternatives are limited to intravenous administration.

The product should be stored at ambient temperature below 25 °C, in its original shielding container, protected from light and moisture. It must be handled by trained personnel using appropriate radiation safety measures.

Indium-111 DTPA is administered by a trained clinician via intrathecal injection, typically through a lumbar puncture, under sterile conditions. Imaging is performed after the tracer has equilibrated within the CSF.

Serious risks include allergic or anaphylactic reactions, radiation‑induced myelopathy, severe infection such as meningitis, and neurological complications like seizures or severe headache with focal deficits. Immediate medical attention is required if these occur.

Patients with known hypersensitivity to indium‑111 or DTPA, those with uncontrolled infections, or individuals for whom intrathecal procedures are contraindicated (e.g., severe coagulopathy) should not receive this radiopharmaceutical.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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