Product image of Indivina (Medroxyprogesterone Acetate, Estradiol Valerate) supplied by GNH India

Indivina

Active Ingredient:
Medroxyprogesterone Acetate, Estradiol Valerate
Origin:
EU

Indivina (Medroxyprogesterone Acetate, Estradiol Valerate)

Medroxyprogesterone acetate and estradiol valerate, the active ingredients in Indivina, are hormonal agents presented as oral tablets for systemic use. They are combined to provide estrogen‑progestogen therapy in women requiring hormone replacement.

GNH India supplies Indivina as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Indivina combines medroxyprogesterone acetate and estradiol valerate to provide hormonal therapy for conditions related to estrogen deficiency.

  • Menopausal symptom relief: reduces hot flashes, night sweats, and vaginal atrophy.
  • Osteoporosis prevention: helps maintain bone mineral density in postmenopausal women.
  • Hypoestrogenic states: restores estrogen levels in women with ovarian insufficiency.

How It Works

  • Medroxyprogesterone acetate binds to progesterone receptors, exerting progestogenic activity that opposes estrogen‑induced endometrial proliferation. Estradiol valerate is hydrolyzed to estradiol, which activates estrogen receptors (ERα and ERβ) and modulates gene transcription involved in bone metabolism, lipid regulation, and vasomotor control, thereby restoring hormonal balance.

Side Effects

Indivina may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea
  • Breast tenderness
  • Headache
  • Weight gain
  • Mood changes
  • Irregular vaginal bleeding

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism
  • Stroke or myocardial infarction
  • Severe liver dysfunction
  • Allergic reactions such as rash or angioedema
  • Visual disturbances
  • Unexplained abdominal pain

Precautions & Warnings

Before initiating therapy, clinicians should evaluate individual risk factors and monitor patients regularly.

  • Assess thromboembolic risk: review personal or family history of clotting disorders.
  • Screen for cardiovascular disease: consider hypertension, smoking status, and lipid profile.
  • Monitor liver function: avoid use in severe hepatic impairment.
  • Contraindicated in estrogen‑dependent tumors: do not use in known breast or endometrial cancer.
  • Pregnancy and lactation: not recommended during pregnancy or while breastfeeding.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Indivina can interact with several drug classes; awareness of major and moderate interactions helps prevent adverse events.

Major Interactions (Avoid)

  • Combined oral anticoagulants: increased risk of thrombosis.
  • Selective serotonin reuptake inhibitors: may heighten bleeding tendency.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): raise hormone plasma levels.
  • CYP3A4 inducers (e.g., rifampicin): reduce hormonal efficacy.
  • Tamoxifen: antagonizes estrogenic effects.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: possible alteration of blood pressure control.
  • Lithium: potential increase in lithium serum concentrations.
  • Carbamazepine: may lower hormone concentrations.
  • Phenobarbital: may diminish therapeutic effect.
  • St. John’s wort and other herbal inducers: could affect metabolism.

Frequently Asked Questions

Indivina is a combined oral hormone preparation that provides estrogen and progestogen activity. It is prescribed mainly for hormone replacement therapy in postmenopausal women to alleviate vasomotor symptoms, protect the endometrium, and help prevent bone loss.

Medroxyprogesterone acetate binds to progesterone receptors in target tissues, delivering progestogenic effects that counterbalance estrogen‑driven endometrial proliferation. This action reduces the risk of uncontrolled uterine bleeding when estrogen is administered concurrently.

The specific dose and dosing schedule of Indivina are determined by the prescribing clinician based on the patient’s age, clinical condition, and therapeutic goals. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Indivina is not recommended for use during pregnancy or while breastfeeding because the hormonal components can affect fetal development and milk production. Women of child‑bearing potential should use effective contraception and discuss any pregnancy plans with their healthcare provider.

To order Indivina, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Indivina delivers both estradiol (a natural estrogen) and medroxyprogesterone acetate (a synthetic progestogen), whereas many other HRT products use synthetic estrogens such as ethinyl estradiol. The natural estradiol component may provide a metabolic profile closer to endogenous hormones, but individual response varies and should be evaluated by a clinician.

Indivina tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat, and direct sunlight to maintain potency throughout the shelf life.

Indivina is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, cardiovascular complications like stroke or myocardial infarction, severe liver dysfunction, and allergic reactions. Patients should seek immediate medical attention if they experience unexplained leg pain, shortness of breath, chest pain, severe abdominal pain, or signs of an allergic reaction.

Indivina is contraindicated in women with a history of estrogen‑dependent cancers (e.g., breast or endometrial cancer), active or past thromboembolic disease, uncontrolled hypertension, severe liver disease, or known hypersensitivity to either component. It should also be avoided during pregnancy and lactation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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