Product image of Indivina (Medroxyprogesterone Acetate, Estradiol Valerate) supplied by GNH India

Indivina

Active Ingredient:
Medroxyprogesterone Acetate, Estradiol Valerate
Origin:
EU

Indivina (Medroxyprogesterone Acetate, Estradiol Valerate)

Medroxyprogesterone acetate, the active ingredient in Indivina, is a combined estrogen‑progestogen oral contraceptive presented as a tablet for oral use. Together with estradiol valerate it prevents pregnancy and helps regulate menstrual cycles in women of reproductive age.

GNH India supplies Indivina as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Indivina is a combined estrogen‑progestogen oral contraceptive used in the reproductive health field. It provides reliable contraception and menstrual management.

  • Prevention of pregnancy: offers a highly effective, reversible method of birth control.
  • Regulation of menstrual cycles: promotes more predictable bleeding patterns and reduces dysmenorrhea.
  • Management of hormone‑related menstrual disorders: helps control heavy or irregular bleeding associated with hormonal imbalance.

How It Works

  • Medroxyprogesterone acetate and estradiol valerate act together to suppress the hypothalamic‑pituitary‑ovarian axis. The progestogenic component inhibits luteinizing hormone (LH) and follicle‑stimulating hormone (FSH) release, preventing ovulation, while the estrogen component stabilises the endometrium and provides feedback that further reduces gonadotropin secretion, decreasing the chance of implantation.

Side Effects

Indivina may cause a range of adverse reactions. Most are mild and transient, but rare serious events can occur.

Common Side Effects

  • Nausea or gastrointestinal discomfort
  • Breast tenderness or enlargement
  • Headache or migraine
  • Weight gain or fluid retention
  • Mood changes or irritability
  • Spotting or breakthrough bleeding

Serious or Rare Side Effects

  • Venous thromboembolism (deep‑vein thrombosis, pulmonary embolism)
  • Arterial thrombosis (stroke, myocardial infarction)
  • Severe hypertension
  • Liver dysfunction or cholestasis
  • Gallbladder disease (biliary colic, cholelithiasis)
  • Anaphylaxis or severe allergic reaction

Precautions & Warnings

Before prescribing Indivina, clinicians should consider several safety factors.

  • Cardiovascular risk assessment: evaluate history of thrombosis, hypertension, or smoking.
  • Liver function review: avoid use in active liver disease or severe impairment.
  • Cancer screening: contraindicated in estrogen‑sensitive malignancies.
  • Smoking status: advise cessation, especially in women over 35.
  • Concomitant medication check: assess for drugs that may alter hormonal efficacy.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Indivina can interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may reduce anticoagulant effect.
  • Enzyme‑inducing antiepileptics (phenytoin, carbamazepine): can lower hormone levels.
  • Rifampin: increases metabolism of both hormones, decreasing contraceptive reliability.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (tetracycline, fluoroquinolones): may slightly reduce contraceptive efficacy.
  • Antifungal agents (ketoconazole, itraconazole): can increase hormone concentrations, raising side‑effect risk.

Frequently Asked Questions

Indivina is a combined estrogen‑progestogen oral tablet indicated for reliable contraception and for regulating menstrual cycles in women of reproductive age. It helps prevent pregnancy and can provide more predictable bleeding patterns.

Medroxyprogesterone acetate acts as a progestogen that suppresses the hypothalamic‑pituitary‑ovarian axis, reducing luteinizing hormone and follicle‑stimulating hormone release. This inhibition prevents ovulation, while estradiol valerate adds estrogenic feedback that stabilises the endometrium.

The dosing regimen for Indivina is determined by the prescribing healthcare professional. Typically, it is taken as a daily oral tablet according to the prescriber’s instructions, but exact strength and schedule are set on an individual basis.

Indivina is contraindicated during pregnancy because it is designed to prevent conception. Its safety during breastfeeding has not been definitively established; clinicians usually advise caution and assess risks versus benefits before prescribing to nursing mothers.

To order Indivina, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indivina contains medroxyprogesterone acetate and estradiol valerate, a formulation that offers a balance of progestogenic and estrogenic activity similar to other combined pills. Compared with products using ethinyl estradiol, estradiol valerate may have a slightly different metabolic profile, but overall contraceptive efficacy remains comparable.

Indivina tablets should be stored at ambient temperature, below 25 °C, in their original blister pack or container. Keep them away from moisture, heat and direct sunlight to maintain potency.

Indivina is taken orally, usually once daily at the same time each day. The tablet is swallowed whole with water and should be started according to the prescriber’s schedule, often on the first day of the menstrual cycle.

The most serious risks include venous or arterial thromboembolism, severe hypertension, liver disorders, and rare allergic reactions such as anaphylaxis. Patients should be educated to seek immediate medical attention if they experience symptoms like sudden chest pain, shortness of breath, severe headache, or jaundice.

Indivina should not be used by women with a history of thromboembolic disease, uncontrolled hypertension, active liver disease, estrogen‑dependent tumors, or who are known to be pregnant. Smoking women over 35 years of age are also advised against using combined oral contraceptives.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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