Product image of Indivina (Medroxyprogesterone Acetate, Estradiol Valerate) supplied by GNH India

Indivina

Active Ingredient:
Medroxyprogesterone Acetate, Estradiol Valerate
Origin:
EU

Indivina (Medroxyprogesterone Acetate, Estradiol Valerate)

Medroxyprogesterone acetate, the active ingredient in Indivina, is a combined estrogen‑progestogen presented as an oral tablet for oral use. It is used to prevent pregnancy in women of reproductive age.

GNH India supplies Indivina as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Indivina, a combined estrogen‑progestogen contraceptive, is used to prevent pregnancy and manage hormone‑related menstrual conditions.

  • Prevention of pregnancy: provides reliable hormonal contraception for women of reproductive age.
  • Menstrual cycle regulation: helps achieve more regular bleeding patterns.
  • Treatment of dysmenorrhea: reduces painful menstrual cramps associated with ovulatory cycles.

How It Works

  • Indivina works by delivering medroxyprogesterone acetate and estradiol valerate, which together suppress the mid‑cycle surge of luteinising hormone and follicle‑stimulating hormone, thereby inhibiting ovulation. The progestogenic component also thickens cervical mucus and induces endometrial changes that reduce the likelihood of fertilisation and implantation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Breast tenderness: increased sensitivity or swelling.
  • Headache: occasional tension‑type headaches.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or emotional fluctuations.
  • Breakthrough bleeding: spotting between periods.

Serious or Rare Side Effects

  • Venous thromboembolism: deep‑vein clot formation.
  • Arterial thrombosis: risk of heart attack or stroke.
  • Hypertension: new or worsening high blood pressure.
  • Liver dysfunction: abnormal liver enzymes or jaundice.
  • Gallbladder disease: formation of gallstones.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before prescribing Indivina, clinicians should consider several safety factors.

  • Assess thrombotic risk: evaluate personal or family history of clotting disorders.
  • Screen for hypertension: monitor blood pressure prior to initiation.
  • Review smoking status: avoid use in women over 35 who smoke.
  • Check liver function: contraindicated in severe hepatic disease.
  • Consider breast cancer history: avoid in active or recent breast cancer.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Indivina may interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce contraceptive efficacy.
  • Anticoagulants (e.g., warfarin): may increase clotting risk.
  • Antiretrovirals (e.g., efavirenz): may lower hormone levels and effectiveness.

Moderate Interactions (Monitor Closely)

  • Antifungals (e.g., ketoconazole): may raise hormone concentrations.
  • SSRIs (e.g., fluoxetine): may increase bleeding tendency.
  • Diuretics (e.g., hydrochlorothiazide): may affect electrolyte balance.

Frequently Asked Questions

Indivina is a prescription oral contraceptive that combines medroxyprogesterone acetate and estradiol valerate to prevent pregnancy. It is also used to help regulate menstrual cycles and relieve menstrual‑related symptoms such as painful cramps.

Medroxyprogesterone acetate, together with estradiol valerate, suppresses the mid‑cycle surge of luteinising hormone and follicle‑stimulating hormone, preventing ovulation. The progestogen also thickens cervical mucus and alters the endometrium, creating an environment that is unfavorable for fertilisation and implantation.

The specific dose and regimen of Indivina are determined by the prescribing healthcare professional based on the patient’s medical history and treatment goals. Patients should follow the prescriber’s instructions and not alter the dosing schedule on their own.

Indivina is intended for use as a contraceptive and should not be taken during pregnancy. If pregnancy occurs, the medication should be discontinued. Safety during breastfeeding has not been fully established; clinicians usually advise caution and may recommend alternative methods.

To order Indivina, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indivina contains medroxyprogesterone acetate and estradiol valerate, which differ from many combined pills that use ethinyl‑estradiol and various progestins. This formulation may offer a more natural estrogen component and a distinct progestogenic profile, but efficacy and safety are comparable when used as directed.

Indivina tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Indivina is taken orally, usually once daily at the same time each day, as directed by the prescriber. The tablets are swallowed with water and should be started on the first day of the menstrual period or as instructed in the prescribing information.

The most serious risks include venous thromboembolism, arterial thrombosis (such as heart attack or stroke), severe hypertension, and liver dysfunction. Patients should be aware of symptoms like unexplained leg pain, chest discomfort, severe headache, or yellowing of the skin and seek immediate medical attention.

Indivina is contraindicated in women with a history of thromboembolic disorders, uncontrolled hypertension, active or past breast cancer, severe liver disease, or in smokers over 35 years of age. It should also be avoided during pregnancy and in individuals known to be allergic to any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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