Product image of Indivina (Medroxyprogesterone Acetate, Estradiol Valerate) supplied by GNH India

Indivina

Active Ingredient:
Medroxyprogesterone Acetate, Estradiol Valerate
Origin:
EU

Indivina (Medroxyprogesterone Acetate, Estradiol Valerate)

Medroxyprogesterone acetate, the active ingredient in Indivina, is a combined estrogen‑progestogen presented as an oral tablet for oral use. It is used to replace deficient endogenous hormones, alleviating menopausal symptoms and protecting the endometrium in post‑menopausal women.

GNH India supplies Indivina as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Indivina is a combined estrogen‑progestogen indicated for conditions related to estrogen deficiency and menopause.

  • Menopausal symptoms: relief of hot flashes, night sweats, and vaginal atrophy.
  • Prevention of osteoporosis: helps maintain bone density in post‑menopausal women.
  • Endometrial protection: reduces risk of estrogen‑induced endometrial hyperplasia when used with estrogen therapy.

How It Works

  • Medroxyprogesterone acetate provides progestogenic activity by binding to progesterone receptors, while estradiol valerate is hydrolyzed to estradiol, activating estrogen receptors. The combined action restores hormonal balance, alleviating vasomotor and urogenital symptoms of menopause and counteracting estrogen‑driven endometrial proliferation.

Side Effects

Common side effects are generally mild and reversible.

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Weight gain
  • Mood changes
  • Vaginal spotting

Serious or Rare Side Effects

  • Venous thromboembolism
  • Stroke or transient ischemic attack
  • Liver dysfunction (elevated enzymes, cholestasis)
  • Severe allergic reaction (anaphylaxis)
  • Hyperglycemia in diabetic patients

Precautions & Warnings

Before initiating therapy, clinicians should evaluate individual risk factors and monitor patients regularly.

  • Cardiovascular assessment: evaluate history of thromboembolic disease or clotting disorders.
  • Breast health: perform regular clinical exams and imaging as indicated.
  • Liver function: monitor enzymes in patients with hepatic impairment.
  • Bone health: consider baseline bone mineral density testing.
  • Hormone‑dependent tumors: avoid use in patients with known estrogen‑sensitive cancers.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Drug interactions may alter efficacy or increase risk of adverse events.

Major Interactions (Avoid)

  • Combined oral contraceptives: additive risk of thromboembolism.
  • Anticoagulants (e.g., warfarin): potential alteration of anticoagulant effect.
  • Strong CYP3A4 inducers (e.g., rifampicin): may reduce hormone plasma levels.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: possible fluid retention may affect blood pressure control.
  • SSRIs and SNRIs: may increase incidence of mood changes.
  • Herbal supplements such as St. John’s wort: could decrease hormonal effectiveness.
  • Antidiabetic agents: monitor glucose as hormones may affect glycemic control.

Frequently Asked Questions

Indivina is prescribed for hormone replacement therapy in post‑menopausal women. It helps relieve vasomotor symptoms such as hot flashes, supports bone health, and provides progestogenic protection against estrogen‑induced endometrial hyperplasia.

Medroxyprogesterone acetate binds to progesterone receptors, delivering progestogenic activity, while estradiol valerate is converted to estradiol, activating estrogen receptors. Together they restore hormonal balance, alleviating menopausal symptoms and preventing excessive endometrial growth.

The specific dose and regimen of Indivina are determined by the prescribing clinician based on individual patient factors, therapeutic goals, and local prescribing guidelines. Patients should follow the prescriber’s instructions exactly.

Indivina is intended for post‑menopausal hormone replacement and is not recommended for use during pregnancy or lactation. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative treatments with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Indivina combines a progestogen (medroxyprogesterone acetate) with an estrogen (estradiol valerate) in a single oral formulation, offering both symptom relief and endometrial protection. Compared with estrogen‑only products, it reduces the risk of endometrial hyperplasia, while its oral route may be preferred over transdermal or injectable alternatives for some patients.

Indivina tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat, and direct sunlight to maintain potency throughout the shelf life.

Indivina is taken orally, usually once daily, with or without food, as directed by the prescriber. Patients should swallow the tablet whole with water and avoid crushing or chewing unless specifically instructed.

Serious risks include venous thromboembolism, stroke, and liver dysfunction. Patients with a history of clotting disorders, cardiovascular disease, or liver disease should be closely monitored, and any signs of serious adverse events should prompt immediate medical evaluation.

Indivina is contraindicated in women with known or suspected hormone‑dependent cancers (e.g., breast or uterine cancer), active thromboembolic disease, severe liver impairment, or unexplained vaginal bleeding. It should also be avoided in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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