Product image of Indivina (Medroxyprogesterone Acetate, Estradiol Valerate) supplied by GNH India

Indivina

Active Ingredient:
Medroxyprogesterone Acetate, Estradiol Valerate
Origin:
EU

Indivina (Medroxyprogesterone Acetate, Estradiol Valerate)

Medroxyprogesterone acetate, the active ingredient in Indivina, is a combined estrogen and progestogen presented as an oral tablet for oral use. It is employed in hormone replacement therapy to alleviate menopausal symptoms and support estrogen‑progestogen balance in women.
GNH India supplies Indivina as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Indivina is a combined estrogen‑progestogen medication used in hormone replacement therapy for menopausal and postmenopausal conditions.

  • Menopausal vasomotor symptoms: reduces frequency and severity of hot flashes and night sweats.
  • Postmenopausal osteoporosis prevention: helps maintain bone mineral density and reduces fracture risk.
  • Estrogen deficiency after surgical menopause: restores hormonal balance in women with an intact uterus.

How It Works

  • Medroxyprogesterone acetate binds to progesterone receptors, providing progestogenic activity that opposes estrogen‑induced endometrial proliferation, while estradiol valerate is hydrolyzed to estradiol, which activates estrogen receptors (ERα and ERβ) throughout target tissues. The combined action restores the natural estrogen‑progestogen ratio, alleviating menopausal symptoms and supporting bone metabolism.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Breast tenderness: swelling or discomfort.
  • Headache: transient tension‑type pain.
  • Bloating: abdominal fullness or mild edema.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or mild depression.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Stroke or transient ischemic attack.
  • Myocardial infarction: heart attack risk.
  • Liver dysfunction: abnormal liver enzymes or hepatitis.
  • Gallbladder disease: biliary colic or cholelithiasis.
  • Breast cancer risk: increased incidence with long‑term use.

Precautions & Warnings

Before initiating therapy, evaluate patient history and risk factors.

  • Cardiovascular assessment: screen for hypertension, clotting disorders, or prior thromboembolic events.
  • Liver function: monitor hepatic enzymes in patients with liver disease.
  • Cancer history: avoid in women with estrogen‑dependent tumors.
  • Bone health: consider baseline bone mineral density testing.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Indivina may interact with several medicines that affect coagulation, hormone metabolism, or blood pressure.

Major Interactions (Avoid)

  • Combined oral contraceptives: increased risk of venous thrombosis.
  • Anticoagulants (warfarin, DOACs): altered anticoagulant effect, requiring close monitoring.
  • Strong CYP3A4 inhibitors (ketoconazole, itraconazole): raise hormone concentrations and may increase adverse events.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (rifampin, carbamazepine): reduce hormone levels, potentially diminishing efficacy.
  • Antihypertensives (ACE inhibitors, diuretics): may require blood pressure adjustments due to fluid retention.

Frequently Asked Questions

Indivina is a prescription oral tablet that combines medroxyprogesterone acetate and estradiol valerate. It is used in hormone replacement therapy to relieve menopausal symptoms such as hot flashes, to help prevent postmenopausal bone loss, and to restore hormonal balance in women who have undergone surgical menopause.

Medroxyprogesterone acetate activates progesterone receptors, providing progestogenic effects that protect the uterine lining. Estradiol valerate is converted to estradiol, which binds estrogen receptors throughout the body, alleviating vasomotor symptoms and supporting bone metabolism. The combination mimics the natural estrogen‑progestogen ratio.

The specific dose and dosing schedule of Indivina are determined by the prescribing clinician based on the individual’s age, health status, and therapeutic goals. Patients should follow the prescriber’s instructions and not alter the dose without medical advice.

Indivina is contraindicated in pregnancy because the hormones can affect fetal development. It is also not recommended during breastfeeding, as estrogen and progestogen can pass into breast milk and may influence milk production. Women who are pregnant, planning pregnancy, or nursing should discuss alternatives with their healthcare provider.

To order Indivina, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Indivina provides a fixed‑dose combination of medroxyprogesterone acetate and estradiol valerate, offering convenience over separate estrogen and progestogen tablets. Compared with estradiol‑only products, it includes progestogen to protect the endometrium in women with an intact uterus, reducing the need for additional medication.

Indivina tablets should be stored at ambient temperature, below 25 °C. Keep them in the original container, protect from moisture, heat, and direct sunlight. Do not store in the bathroom or near a kitchen sink to maintain product stability.

Indivina is taken orally, usually once daily as directed by a healthcare professional. The tablet should be swallowed whole with water and can be taken with or without food, unless the prescriber advises otherwise.

The most serious risks include venous thromboembolism, stroke, myocardial infarction, liver dysfunction, gallbladder disease, and an increased risk of estrogen‑dependent cancers such as breast cancer. Patients should be monitored for signs of clotting, liver issues, or unusual pain and report any concerns promptly.

Indivina should not be used by women with a history of thromboembolic disorders, active or past estrogen‑dependent cancers, uncontrolled hypertension, severe liver disease, or known hypersensitivity to medroxyprogesterone acetate or estradiol. It is also contraindicated during pregnancy and breastfeeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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