Product image of Indix Sr (Indapamide) supplied by GNH India

Indix Sr

Active Ingredient:
Indapamide
Origin:
EU

Indix Sr (Indapamide)

Indapamide, the active ingredient in Indix Sr, is a thiazide‑like diuretic presented as an oral tablet for oral use. It is employed to lower high blood pressure and to reduce fluid accumulation in patients with heart‑failure‑related or renal‑disease‑related edema.

GNH India supplies Indix Sr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution, including temperature‑controlled shipping where required. Customers benefit from dedicated technical support and regulatory expertise.

Manufacturer / TM Owner

Teva Pharmaceuticals Polska Sp. Z O.O.

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Indications & Clinical Uses

  • Indapamide is used to manage conditions within the cardiovascular and renal disease pathways.
  • Hypertension: reduces elevated arterial pressure.
  • Edema associated with heart failure: promotes fluid loss to relieve congestive symptoms.
  • Edema associated with renal disease: facilitates diuresis to decrease fluid overload.

How It Works

  • Indapamide acts on the distal convoluted tubule of the nephron by inhibiting the Na⁺/Cl⁻ cotransporter. This blockade reduces sodium and chloride reabsorption, leading to increased urinary excretion of water and electrolytes. The resulting diuresis lowers plasma volume and peripheral vascular resistance, contributing to blood‑pressure reduction. Additionally, modest vasodilatory effects further decrease systemic resistance. The drug also modestly enhances prostaglandin synthesis, which may contribute to its vasodilatory action.

Side Effects

Indapamide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Headache
  • Increased urination
  • Electrolyte imbalance (especially low potassium)
  • Nausea

Serious or Rare Side Effects

  • Severe dehydration
  • Hyponatremia
  • Hypokalemia
  • Allergic reactions such as rash or angioedema
  • Blood dyscrasias (e.g., agranulocytosis)
  • Acute renal failure

Precautions & Warnings

  • Before initiating Indapamide, several safety considerations should be reviewed.
  • Monitor electrolytes: check serum sodium and potassium regularly.
  • Assess renal function: evaluate kidney parameters before and during therapy.
  • Use caution in severe hepatic impairment: contraindicated in marked liver disease.
  • Monitor gout: indapamide may increase serum uric acid levels.
  • Pregnancy and lactation: use only if potential benefits justify the risks.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Indapamide can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Lithium: may increase lithium toxicity.
  • NSAIDs: may reduce diuretic efficacy and impair renal function.
  • ACE inhibitors/ARBs: risk of excessive potassium loss.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: additive blood‑pressure‑lowering effect.
  • Digoxin: may increase digoxin serum concentrations.
  • Antidiabetic drugs: may enhance hypoglycaemic action.

Frequently Asked Questions

Indix Sr contains indapamide, a thiazide‑like diuretic that is prescribed to lower high blood pressure and to reduce fluid retention in patients with edema caused by heart failure or chronic kidney disease.

Indapamide blocks the sodium‑chloride cotransporter in the distal convoluted tubule of the kidney, decreasing reabsorption of these ions. This promotes water excretion, lowers plasma volume, and reduces peripheral vascular resistance, which together help control blood pressure and diminish edema.

The appropriate dose of Indix Sr is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The pregnancy category for indapamide is not clearly defined. It should only be used during pregnancy or lactation when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and after consultation with a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indapamide shares the same thiazide‑like mechanism as hydrochlorothiazide but generally provides a longer duration of action and may have a more favorable metabolic profile, with less impact on blood glucose and lipid levels. Choice between agents depends on individual patient factors and clinician preference.

Indix Sr tablets should be stored below 25 °C in a dry place, kept in the original container, and protected from moisture and direct sunlight. Do not store in the bathroom or near heat sources, and keep out of reach of children.

Indix Sr is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should follow the specific instructions given by their prescriber to ensure consistent absorption and effect.

The most serious risks include severe dehydration, significant electrolyte disturbances such as hyponatremia or hypokalemia, acute kidney injury, and rare allergic reactions. Patients should be monitored for signs of these conditions, especially during the initial weeks of therapy.

Indix Sr is contraindicated in individuals with anuria, severe renal impairment, known hypersensitivity to indapamide or other sulfonamide drugs, and in patients with severe hepatic disease. It should also be used with caution in those with gout or a history of electrolyte abnormalities.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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