Product image of Indocid (Indometacin) supplied by GNH India

Indocid

Active Ingredient:
Indometacin
Origin:
EU

Indocid (Indometacin)

Indomethacin, the active ingredient in Indocid, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is employed to relieve pain and inflammation in conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis and acute inflammatory episodes.

GNH India supplies Indocid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance. Our distribution network ensures reliable delivery to diverse healthcare settings across multiple continents.

Manufacturer / TM Owner

H.A.C. Pharma

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Indications & Clinical Uses

  • Indocid (indomethacin) acts on inflammatory pathways associated with various arthritic and pain conditions.
  • Rheumatoid arthritis: reduces joint inflammation and pain, improving function.
  • Osteoarthritis: alleviates chronic joint discomfort and swelling.
  • Ankylosing spondylitis: diminishes spinal inflammation and stiffness.
  • Gouty arthritis: controls acute gout attacks by lowering inflammatory response.
  • Acute pain and inflammation: provides rapid relief for musculoskeletal injuries and postoperative discomfort.

How It Works

  • Indomethacin non‑selectively inhibits cyclooxygenase enzymes COX‑1 and COX‑2, which blocks the conversion of arachidonic acid to prostaglandins. By decreasing prostaglandin synthesis, it reduces inflammation, pain, and fever at the site of tissue injury or disease.

Side Effects

Indocid may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal upset, such as nausea or dyspepsia.
  • Headache or dizziness.
  • Mild skin rash.
  • Elevated liver enzymes.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Acute renal impairment or failure.
  • Severe hypersensitivity reactions, including anaphylaxis.

Precautions & Warnings

Before prescribing Indocid, clinicians should evaluate patient‑specific risk factors and monitor relevant organ functions.

  • Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
  • Monitor renal function: adjust use in those with impaired kidney function.
  • Check hepatic status: discontinue if significant liver enzyme elevation occurs.
  • Avoid in known hypersensitivity to indomethacin or other NSAIDs.
  • Use the lowest effective dose for the shortest duration needed.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Indocid can interact with several drug classes, influencing efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or corticosteroids: heightened gastrointestinal toxicity.
  • Lithium: may raise serum lithium levels, risking toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: possible reduction in renal function.
  • Methotrexate: potential for increased methotrexate toxicity.

Frequently Asked Questions

Indocid contains indomethacin, an NSAID that is commonly prescribed for inflammatory joint diseases such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and gouty arthritis, as well as for short‑term relief of acute musculoskeletal pain and inflammation.

Indomethacin blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin production, it reduces inflammation, pain, and fever at the affected site.

The appropriate dose of Indocid is determined by the prescribing healthcare professional based on the specific indication, severity of symptoms, patient age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions exactly.

The safety of indomethacin in pregnancy and lactation has not been definitively established. It is generally avoided in the third trimester because of potential fetal risks, and breastfeeding mothers should consult their physician before use.

To request Indocid, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Indocid (indomethacin) is a potent non‑selective NSAID with strong anti‑inflammatory activity, often considered more effective for certain gout attacks and severe arthritis than milder agents like ibuprofen. However, its higher risk of gastrointestinal and renal side effects may lead clinicians to choose alternative NSAIDs for patients with those concerns.

Indocid should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not store it in bathrooms or other humid environments.

Indocid is supplied as an oral formulation that should be swallowed whole with a full glass of water. It can be taken with food or milk to lessen stomach irritation, but patients must follow the dosing schedule prescribed by their healthcare provider.

The most serious adverse events linked to Indocid include gastrointestinal ulceration or bleeding, severe renal impairment, and life‑threatening hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored closely for any signs of these complications.

Indocid is contraindicated in individuals with known hypersensitivity to indomethacin or other NSAIDs, active gastrointestinal ulcers, severe renal or hepatic impairment, and in the third trimester of pregnancy. It should also be used with caution in patients taking anticoagulants or other drugs that increase bleeding risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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