Product image of Indocid (Indometacin) supplied by GNH India

Indocid

Active Ingredient:
Indometacin
Origin:
EU

Indocid (Indometacin)

Indometacin, the active ingredient in Indocid, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a rectal formulation for rectal use. It reduces inflammation and pain in conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout flares and acute inflammatory pain.

GNH India supplies Indocid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide, with a focus on quality and regulatory compliance.

Manufacturer / TM Owner

H.A.C. Pharma

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Indications & Clinical Uses

Indocid (indometacin) is used to manage inflammatory musculoskeletal disorders by inhibiting prostaglandin‑mediated inflammation.

  • Rheumatoid arthritis: reduces joint pain, swelling and stiffness.
  • Osteoarthritis: alleviates chronic joint discomfort and improves function.
  • Ankylosing spondylitis: decreases spinal inflammation and stiffness.
  • Gout flares: relieves acute gouty arthritis pain.
  • Acute pain and inflammation: provides rapid analgesic effect in various inflammatory conditions.

How It Works

  • Indometacin inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, leading to decreased synthesis of prostaglandins that mediate inflammation, pain and fever. By reducing prostaglandin levels at sites of tissue injury, the drug diminishes vascular permeability, leukocyte infiltration and nociceptor sensitisation, resulting in anti‑inflammatory, analgesic and antipyretic effects.

Side Effects

Indocid may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Abdominal pain: discomfort or cramping in the abdomen.
  • Headache: transient head pain.
  • Dizziness: feeling light‑headed or unsteady.

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding: potentially life‑threatening stomach lesions.
  • Renal impairment: reduced kidney function or acute kidney injury.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before prescribing Indocid, clinicians should consider several safety measures.

  • Assess renal function: monitor serum creatinine and adjust use in renal impairment.
  • Evaluate gastrointestinal risk: avoid in patients with active ulcers or a history of serious GI bleeding.
  • Review cardiovascular status: NSAIDs may increase blood pressure and cardiovascular events.
  • Use the lowest effective dose: limit duration to the shortest period necessary for symptom control.
  • Store at room temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Indocid can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Warfarin: increased risk of bleeding.
  • Lithium: heightened lithium toxicity.
  • Methotrexate: enhanced methotrexate toxicity.

Moderate Interactions (Monitor Closely)

  • SSRIs: additive risk of gastrointestinal bleeding.
  • ACE inhibitors: possible reduction in renal function.
  • Diuretics: may exacerbate nephrotoxicity, especially in volume‑depleted patients.

Frequently Asked Questions

Indocid contains indometacin, an NSAID indicated for the treatment of inflammatory conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout flares and other acute pain states where inflammation is a primary driver of symptoms.

Indometacin blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. By lowering prostaglandin levels, it reduces inflammation, pain, and fever at the site of tissue injury.

The appropriate dose of Indocid is determined by the prescribing healthcare professional based on the specific indication, patient age, weight, renal and hepatic function, and overall clinical response. Patients should follow the prescriber’s instructions exactly.

Safety data for indometacin in pregnancy and lactation are limited. It is generally avoided during the third trimester because of potential fetal risks, and caution is advised while breastfeeding. Clinicians should weigh benefits against possible risks and consider alternative therapies when appropriate.

To place an order, submit an enquiry on the Indocid product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Indocid (indometacin) is a potent NSAID with strong COX inhibition, often considered more effective for certain gout flares and ankylosing spondylitis than some other NSAIDs. However, its gastrointestinal and renal risk profile may be higher, so clinicians balance efficacy against safety when selecting an NSAID for a particular patient.

Store Indocid at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Indocid is supplied as a rectal formulation intended for insertion into the rectum. The exact administration technique should be explained by the healthcare provider, and patients should follow the prescribed schedule and any accompanying instructions for proper use.

The most serious adverse events include gastrointestinal ulceration or bleeding, acute renal failure, severe skin reactions such as Stevens‑Johnson syndrome, and cardiovascular complications. Patients should seek immediate medical attention if they experience signs of bleeding, sudden kidney problems, or severe skin changes.

Indocid is contraindicated in individuals with known hypersensitivity to indometacin or other NSAIDs, active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and in the third trimester of pregnancy. Caution is also advised for patients with uncontrolled hypertension, heart failure or a history of cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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