Indocollyre (Indometacin)

Indometacin ophthalmic solution is an NSAID used to manage ocular inflammatory conditions.

• Postoperative ocular inflammation: reduces swelling and pain after eye surgery.
• Anterior uveitis: controls intra‑ocular inflammation and associated discomfort.
• Ocular pain: provides rapid relief of pain caused by inflammation or injury.

• Indometacin inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes in ocular tissues, decreasing prostaglandin synthesis and lowering the production of other inflammatory mediators. This reduces vasodilation, leukocyte infiltration, and nociceptor activation within the eye, alleviating inflammation and discomfort. The localized ocular delivery concentrates the effect at the site of inflammation while minimizing systemic exposure, making it suitable for short‑term treatment of acute ocular inflammatory episodes.

Indometacin ophthalmic solution may cause ocular and systemic adverse reactions, which are categorized by frequency.

Common Side Effects

• Burning or stinging sensation upon instillation.
• Transient blurred vision.
• Conjunctival hyperemia (redness).
• Increased tearing.
• Foreign body sensation.
• Mild headache.

Serious or Rare Side Effects

• Corneal ulceration or epithelial defect.
• Elevated intra‑ocular pressure.
• Severe allergic reaction (e.g., angio‑edema).
• Persistent or worsening eye pain.
• Vision loss.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis (very rare).

When using Indometacin eye drops, consider the following safety measures.

• Assess for hypersensitivity: avoid use in patients with known indometacin or NSAID allergy.
• Monitor intra‑ocular pressure: use caution in patients with glaucoma.
• Avoid concurrent ocular infections: do not use if active bacterial or viral eye infection is present.
• Limit duration: restrict use to the shortest effective period to reduce risk of corneal toxicity.
• Pregnancy and lactation: safety not established; use only if benefits outweigh risks.
• Store at room temperature: keep in original container, protect from light and moisture.

Indometacin ophthalmic solution can interact with other ocular or systemic agents.

Major Interactions (Avoid)

• Systemic NSAIDs: additive COX inhibition may increase systemic toxicity.
• Topical ocular corticosteroids: may antagonize the anti‑inflammatory effect of indometacin.

Moderate Interactions (Monitor Closely)

• Contact lens wear: may increase drug retention and cause irritation.
• Other ocular decongestants: possible additive vasoconstriction.
• Anticholinergic ophthalmic agents: may affect pupil response and ocular surface comfort.