Product image of Indocollyre (Indometacin) supplied by GNH India

Indocollyre

Active Ingredient:
Indometacin
Origin:
EU

Indocollyre (Indometacin)

Indometacin, the active ingredient in Indocollyre, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an ocular solution for topical eye use. It works by inhibiting cyclooxygenase enzymes, thereby decreasing prostaglandin synthesis and alleviating inflammation and pain in postoperative eye inflammation, uveitis, and other ocular inflammatory conditions.

GNH India supplies Indocollyre as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across EU and other markets through rigorous testing.

Manufacturer / TM Owner

Bausch + Lomb Ireland Limited

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Indications & Clinical Uses

  • Indocollyre (indometacin) is used to manage ocular inflammation by inhibiting prostaglandin‑mediated pathways.
  • Post‑operative eye inflammation: reduces swelling, pain and cellular infiltrates following ocular surgery, helping to restore visual comfort.
  • Uveitis: controls intra‑ocular inflammation, decreasing pain, photophobia and risk of tissue damage in anterior or intermediate uveitis.
  • Other ocular inflammatory conditions: alleviates inflammation in conditions such as allergic conjunctivitis or scleritis, improving patient comfort.

How It Works

  • Indometacin exerts its anti‑inflammatory effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This blockade reduces the conversion of arachidonic acid to prostaglandins and thromboxanes, key mediators of inflammation, pain and vascular permeability in ocular tissues. The resulting decrease in prostaglandin levels diminishes inflammatory cell recruitment and edema in the eye and contributes to faster resolution of postoperative inflammatory responses.

Side Effects

Indometacin ocular solution may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Eye irritation or burning sensation: transient discomfort upon instillation.
  • Redness of the conjunctiva: mild hyperemia that usually resolves.
  • Tearing or increased lacrimation: temporary watery eyes after dosing.
  • Blurred vision: short‑term visual disturbance that clears within minutes.

Serious or Rare Side Effects

  • Corneal ulceration: rare but severe epithelial breakdown requiring immediate medical attention.
  • Anterior uveitis exacerbation: worsening intra‑ocular inflammation.
  • Allergic contact dermatitis: localized hypersensitivity reaction around the eye.

Precautions & Warnings

  • When using Indocollyre, consider the following precautions.
  • Avoid use in patients with known hypersensitivity to indometacin or other NSAIDs: discontinue immediately if reaction occurs.
  • Do not administer to eyes with active infection or ulceration: may delay healing.
  • Use with caution in patients with a history of asthma or nasal polyps: risk of bronchospasm.
  • Monitor intra‑ocular pressure in glaucoma patients: NSAIDs can affect pressure.
  • Avoid concomitant use with other topical ophthalmic NSAIDs unless directed: increased risk of toxicity.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Indometacin ocular solution can interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Systemic NSAIDs: increased risk of systemic adverse effects such as gastrointestinal bleeding.
  • Anticoagulants (e.g., warfarin): potentiation of bleeding risk.
  • Corticosteroid eye drops: may reduce anti‑inflammatory efficacy when combined.

Moderate Interactions (Monitor Closely)

  • Beta‑blocker eye drops: possible additive ocular hypotensive effect.
  • Topical ocular antibiotics: monitor for delayed healing.

Frequently Asked Questions

Indocollyre is an indometacin‑based ocular solution prescribed to treat inflammation of the eye, including postoperative inflammation, uveitis, and other inflammatory eye conditions. It helps reduce swelling, pain, and redness by targeting inflammatory pathways within ocular tissues.

Indometacin inhibits both COX‑1 and COX‑2 enzymes, which blocks the synthesis of prostaglandins that drive inflammation, pain, and vascular leakage. By lowering prostaglandin levels in the eye, the drug reduces inflammatory cell recruitment and edema, providing symptomatic relief.

The dosing regimen for Indocollyre is determined by the prescribing clinician based on the specific condition, severity, and patient response. Healthcare professionals will provide instructions on the number of drops, frequency, and duration of therapy.

Safety data for indometacin ocular use in pregnancy and lactation are limited, and the pregnancy category is listed as unknown. Caution is advised, and the medication should only be used if the potential benefit justifies any potential risk to the fetus or infant.

To request Indocollyre, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indocollyre contains indometacin, a potent non‑selective NSAID, offering strong COX inhibition. Compared with other ophthalmic NSAIDs such as diclofenac or ketorolac, indometacin may provide a faster onset of anti‑inflammatory effect, though individual response and tolerability can vary.

Indocollyre should be stored at room temperature, preferably below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light and moisture, and discard any solution that appears discolored or contains particles.

Indocollyre is applied as eye drops. The patient tilts the head back, pulls down the lower eyelid to form a pocket, and instills the prescribed number of drops. The eye should be gently closed for a few seconds to allow absorption, avoiding blinking or wiping the eye immediately.

Serious adverse events, though rare, include corneal ulceration and worsening of intra‑ocular inflammation such as uveitis exacerbation. Any sudden loss of vision, severe eye pain, or persistent redness should prompt immediate medical evaluation.

Indocollyre is contraindicated in patients with known hypersensitivity to indometacin or any component of the formulation. It should also be avoided in eyes with active infection, ulceration, or in patients with a history of severe asthma or nasal polyps where NSAIDs may trigger bronchospasm.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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