Product image of Indometacin supplied by GNH India

Indometacin

Active Ingredient:
Indometacin
Origin:
EU

Indometacin

Indometacin, the active ingredient in Indometacin, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a tablet for oral use. It reduces inflammation and pain in conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout and acute pain. It is indicated for the management of inflammatory musculoskeletal disorders and acute gout attacks, offering clinicians an option to control pain and swelling.

GNH India supplies Indometacin as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, and clinics worldwide with adherence to stringent quality standards and regulatory requirements.

Manufacturer / TM Owner

Genethics Europe Limited

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Indications & Clinical Uses

Indometacin is an NSAID that reduces inflammation and pain in several musculoskeletal and crystal‑induced arthropathies.

  • Rheumatoid arthritis: alleviates joint inflammation and pain, improving functional ability.
  • Osteoarthritis: decreases cartilage‑related discomfort and swelling during movement.
  • Ankylosing spondylitis: reduces spinal inflammation and stiffness, aiding mobility.
  • Gout: relieves acute gouty arthritis attacks by lowering inflammatory response.
  • Acute pain: provides rapid analgesia for short‑term severe pain episodes.

How It Works

  • Indometacin exerts its effect by non‑selectively inhibiting cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes inflammatory mediators, leading to decreased inflammation, pain, and fever associated with musculoskeletal and crystal‑induced disorders. Additionally, COX inhibition reduces vascular permeability and leukocyte infiltration at sites of inflammation, further contributing to its therapeutic benefit.

Side Effects

Indometacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Peptic ulcer or gastrointestinal bleeding: potentially life‑threatening hemorrhage.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Severe hypersensitivity: anaphylaxis, Stevens‑Johnson syndrome, or toxic epidermal necrolysis.

Precautions & Warnings

Before prescribing Indometacin, clinicians should consider several precautionary measures to minimize risk.

  • Assess renal function: monitor creatinine and adjust use in renal impairment.
  • Evaluate gastrointestinal risk: avoid in patients with active ulcers or history of bleeding.
  • Check cardiovascular status: use cautiously in those with heart disease or hypertension.
  • Review concomitant medications: avoid combining with other NSAIDs or anticoagulants without supervision.
  • Monitor liver enzymes: periodic testing recommended during prolonged therapy.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Indometacin can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • ACE inhibitors or ARBs: may reduce antihypertensive effect and impair renal function.
  • Lithium: heightened lithium levels leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate renal impairment and electrolyte imbalance.
  • Methotrexate: reduced clearance increasing toxicity.
  • Corticosteroids: additive gastrointestinal ulcer risk.

Frequently Asked Questions

Indometacin is prescribed for inflammatory musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, as well as for acute gout attacks and short‑term severe pain. It helps reduce swelling, pain, and stiffness associated with these conditions.

Indometacin works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2. This blocks the formation of prostaglandins, which are key mediators of inflammation, pain, and fever, thereby providing anti‑inflammatory and analgesic effects.

The appropriate dose of Indometacin is set by the prescribing healthcare professional based on the specific indication, severity of symptoms, patient age, renal and hepatic function, and any concomitant medications. No fixed regimen is provided here.

Indometacin falls under an unknown pregnancy category, and safety data are limited. Because NSAIDs can affect fetal development and may pass into breast milk, it is generally avoided unless clearly needed and approved by a physician.

To request Indometacin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Indometacin is a potent non‑selective NSAID with strong anti‑inflammatory activity, often used when rapid symptom control is needed. Compared with ibuprofen or naproxen, it may have a higher risk of gastrointestinal and renal side effects, so clinicians balance efficacy against safety for each patient.

Indometacin tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Indometacin is supplied as an oral tablet and is taken by mouth with or without food, as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed.

Serious risks include gastrointestinal bleeding or ulceration, severe liver injury, and life‑threatening hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for signs of bleeding, liver dysfunction, or rash, and seek immediate medical attention if these occur.

Indometacin should be avoided in individuals with known hypersensitivity to the drug, active peptic ulcer disease, severe renal or hepatic impairment, uncontrolled hypertension, and in patients taking anticoagulants or other NSAIDs without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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