Product image of Indometacin Fiterman (Indometacin) supplied by GNH India

Indometacin Fiterman

Active Ingredient:
Indometacin
Origin:
EU

Indometacin Fiterman (Indometacin)

Indometacin, the active ingredient in Indometacin Fiterman, is a nonsteroidal anti-inflammatory drug presented as a topical formulation for cutaneous use. It reduces pain and inflammation associated with rheumatic and musculoskeletal conditions in adult patients.

GNH India supplies Indometacin Fiterman as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for each batch. Customers benefit from reliable logistics, temperature‑controlled shipping where required, and dedicated technical support throughout the procurement process.

Manufacturer / TM Owner

Fiterman Pharma S.R.L.

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Indications & Clinical Uses

  • Indometacin is employed in several inflammatory and musculoskeletal disorders where cyclo‑oxygenase inhibition reduces symptoms.
  • Rheumatoid arthritis: alleviates joint pain, swelling and stiffness in adult patients.
  • Osteoarthritis: decreases pain and improves joint function in affected joints.
  • Ankylosing spondylitis: reduces spinal inflammation and associated discomfort.
  • Acute gouty arthritis: relieves severe joint pain and inflammation during gout attacks.
  • Post‑operative pain: provides analgesia for surgical wound inflammation.

How It Works

  • Indometacin exerts its anti‑inflammatory and analgesic actions by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes. This blockade reduces the conversion of arachidonic acid to prostaglandins, thereby decreasing inflammatory mediators, pain signaling, and fever generation at the site of tissue injury.

Side Effects

Topical indometacin may cause local and systemic adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Skin irritation or burning at the application site
  • Erythema or redness of the skin
  • Pruritus (itching)
  • Dryness or peeling of the skin
  • Headache
  • Mild gastrointestinal discomfort

Serious or Rare Side Effects

  • Severe allergic reactions such as anaphylaxis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Ulceration or bleeding of the gastrointestinal tract
  • Renal impairment or acute kidney injury
  • Hepatic dysfunction including elevated liver enzymes
  • Blood dyscrasias such as thrombocytopenia

Precautions & Warnings

  • When using indometacin, clinicians should consider several safety measures to minimize risk.
  • Assess renal function: avoid use in patients with severe renal impairment.
  • Monitor gastrointestinal risk: consider gastro‑protective agents in those with ulcer history.
  • Avoid in known hypersensitivity: discontinue if rash or swelling occurs.
  • Caution in cardiovascular disease: NSAIDs may increase thrombotic risk.
  • Limit use during pregnancy: safety not established, especially in third trimester.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Indometacin can interact with other medicines, requiring careful assessment before co‑administration.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Lithium: elevated serum lithium concentrations.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible decline in renal function.
  • Corticosteroids: heightened risk of gastrointestinal ulceration.

Frequently Asked Questions

Indometacin Fiterman is a topical nonsteroidal anti‑inflammatory drug indicated for the relief of pain and inflammation associated with rheumatic and musculoskeletal conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout attacks, and postoperative inflammation.

Indometacin blocks both cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, preventing the formation of prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin synthesis, it diminishes the inflammatory response at the site of application.

The specific dose and frequency are determined by the prescribing healthcare professional based on the patient’s condition, severity, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the amount on their own.

Safety of indometacin in pregnancy and lactation has not been established. It is generally avoided, especially in the third trimester, because of potential risks to the fetus and newborn. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their clinician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature‑controlled requirements) and the necessary import documentation.

Indometacin is a potent NSAID with strong anti‑inflammatory activity, often considered more effective for gout and certain severe arthritic conditions than ibuprofen or naproxen. However, its risk profile for gastrointestinal and renal adverse effects can be higher, so clinicians weigh efficacy against safety when selecting an NSAID for each patient.

The product should be stored at room temperature, below 25 °C, in its original packaging. It must be kept away from moisture, direct sunlight, and sources of heat. Ensure the container is tightly closed to maintain product integrity until use.

Indometacin Fiterman is applied topically to the affected skin area. The prescribed amount is spread thinly and gently massaged into the skin, usually 2–4 times daily, or as directed by the prescriber. Hands should be washed before and after application.

Serious risks include severe allergic reactions (anaphylaxis), life‑threatening skin conditions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, gastrointestinal bleeding or ulceration, acute kidney injury, and significant liver enzyme elevations. Any signs of these conditions require immediate medical attention.

Individuals with known hypersensitivity to indometacin or other NSAIDs, those with active gastrointestinal ulceration, severe renal or hepatic impairment, uncontrolled hypertension, or a history of cardiovascular thrombotic events should avoid using this product. Pregnant women, especially in the third trimester, should also refrain from use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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