Product image of Indometacin Galvex (Indometacin) supplied by GNH India

Indometacin Galvex

Active Ingredient:
Indometacin
Origin:
EU

Indometacin Galvex (Indometacin)

Indometacin, the active ingredient in Indometacin Galvex, is a nonsteroidal anti-inflammatory drug presented as a rectal formulation for local administration. It is used to relieve inflammation and pain associated with rheumatic and musculoskeletal disorders in adult patients. It is indicated for the management of inflammatory joint conditions and acute gout attacks, providing analgesic and anti‑inflammatory effects.

GNH India supplies Indometacin Galvex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance and reliable logistics for global healthcare providers.

Manufacturer / TM Owner

Galvex, Spol. S R.O.

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Indications & Clinical Uses

Indometacin is employed to treat inflammatory and painful conditions affecting the musculoskeletal system.

  • Rheumatoid arthritis: reduces joint inflammation and pain, improving function.
  • Osteoarthritis: alleviates chronic joint discomfort and stiffness.
  • Gout: diminishes acute gouty arthritis attacks and associated swelling.
  • Ankylosing spondylitis: eases spinal inflammation and back pain.
  • Bursitis: lessens inflammation of bursae, restoring mobility.
  • Tendinitis: decreases tendon inflammation and related pain.

How It Works

  • Indometacin inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it lowers inflammation, pain, and fever at the site of tissue injury, providing anti‑inflammatory and analgesic effects.

Side Effects

Indometacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, abdominal pain.
  • Headache or dizziness.
  • Skin rash or mild itching.
  • Elevated liver enzymes without clinical symptoms.
  • Transient increase in blood pressure.
  • Mild renal function changes.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Severe renal impairment or failure.
  • Hepatotoxicity with jaundice.
  • Life‑threatening skin reactions such as Stevens‑Johnson syndrome.
  • Anaphylactic or severe hypersensitivity reactions.
  • Cardiovascular events such as myocardial infarction.

Precautions & Warnings

Before prescribing Indometacin, clinicians should consider patient‑specific risk factors and monitor therapy appropriately.

  • Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
  • Monitor renal function: use caution in those with pre‑existing kidney disease.
  • Evaluate cardiovascular status: consider risk of thrombotic events in high‑risk patients.
  • Use the lowest effective dose for the shortest duration needed.
  • Avoid in individuals with known hypersensitivity to indometacin or other NSAIDs.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Indometacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Lithium: heightened lithium toxicity.
  • Methotrexate: enhanced methotrexate toxicity.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): potential for increased bleeding.
  • Corticosteroids: additive gastrointestinal ulcer risk.
  • ACE inhibitors or diuretics: possible reduction in renal function.

Frequently Asked Questions

Indometacin Galvex is prescribed for inflammatory musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, gout, ankylosing spondylitis, bursitis and tendinitis. It helps reduce pain, swelling and stiffness by targeting the underlying inflammation in these conditions.

Indometacin blocks the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin production, the drug diminishes the inflammatory response, thereby reducing pain, swelling and fever at the affected site.

The appropriate dose of Indometacin Galvex is determined by the prescribing healthcare professional based on the individual’s condition, severity, age, renal and hepatic function, and other concurrent medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of indometacin in pregnancy and lactation has not been definitively established. It is generally avoided during the third trimester because of potential fetal complications, and breastfeeding mothers should consult their physician, as the drug may pass into breast milk.

To request Indometacin Galvex, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indometacin is a potent NSAID with strong anti‑inflammatory activity, often considered more effective for gout and certain rheumatic conditions than some other NSAIDs. However, its gastrointestinal and renal risk profile may be higher, so clinicians balance efficacy against safety when selecting an NSAID for a patient.

Indometacin Galvex should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and sources of heat to maintain its stability and potency throughout its shelf life.

Indometacin Galvex is supplied as a rectal formulation. The prescribed dose is inserted into the rectum, usually using a pre‑filled applicator or suppository, following the healthcare provider’s instructions for proper placement and timing.

Serious risks include gastrointestinal ulceration or bleeding, severe renal impairment, hepatotoxicity, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored for signs of these events and seek immediate medical attention if they occur.

Indometacin Galvex is contraindicated in individuals with known hypersensitivity to indometacin or other NSAIDs, active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and in the third trimester of pregnancy. Physicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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