Product image of Indometacin Mcc (Indometacin) supplied by GNH India

Indometacin Mcc

Active Ingredient:
Indometacin
Origin:
EU

Indometacin Mcc (Indometacin)

Indometacin, the active ingredient in Indometacin Mcc, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a suppository for rectal use. It treats pain and inflammation associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gouty arthritis and other inflammatory conditions.

GNH India supplies Indometacin Mcc as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Magistra C&c

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Indications & Clinical Uses

Indometacin is employed in the management of inflammatory musculoskeletal disorders and acute gout attacks.

  • Rheumatoid arthritis: reduces joint pain, swelling and stiffness.
  • Osteoarthritis: alleviates chronic joint discomfort and improves mobility.
  • Ankylosing spondylitis: diminishes spinal inflammation and pain.
  • Acute gouty arthritis: relieves sudden joint swelling and severe pain.
  • General pain and inflammation: provides symptomatic relief in various acute inflammatory conditions.

How It Works

  • Indometacin exerts its therapeutic effect by non‑selectively inhibiting cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, pain perception, and fever, producing its analgesic, anti‑inflammatory, and antirheumatic actions.

Side Effects

Indometacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort or nausea.
  • Headache or dizziness.
  • Skin rash or mild itching.
  • Mild abdominal pain.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Acute renal impairment or failure.
  • Severe liver injury or hepatitis.

Precautions & Warnings

Indometacin should be used with caution and under medical supervision.

  • Renal function: monitor in patients with existing kidney disease.
  • Gastrointestinal risk: avoid in individuals with a history of ulcer or bleeding.
  • Cardiovascular health: use cautiously in patients with heart disease or hypertension.
  • Concomitant anticoagulants: increased risk of bleeding; monitor coagulation parameters.
  • Pregnancy and lactation: safety not established; avoid if possible.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Indometacin can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Lithium: increased lithium serum concentrations.
  • Methotrexate: amplified toxicity and bone‑marrow suppression.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: may exacerbate renal impairment.
  • Corticosteroids: increased likelihood of gastrointestinal ulceration.

Frequently Asked Questions

Indometacin Mcc is prescribed for inflammatory joint disorders such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis, as well as for general pain and inflammation where a non‑steroidal anti‑inflammatory drug is appropriate.

Indometacin works by non‑selectively blocking cyclooxygenase enzymes (COX‑1 and COX‑2), which reduces the formation of prostaglandins—key mediators of inflammation, pain, and fever—thereby providing analgesic and anti‑inflammatory effects.

The exact dose and frequency of Indometacin Mcc are determined by the prescribing clinician based on the patient’s condition, severity, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Indometacin Mcc in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be used only if the potential benefit justifies the potential risk, and breastfeeding mothers should consult their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indometacin is a potent non‑selective NSAID with strong anti‑inflammatory activity, often considered more effective for gout attacks compared with some other NSAIDs. However, its gastrointestinal and renal risk profile may be higher, so clinicians weigh benefits against potential adverse effects when selecting therapy.

Indometacin Mcc suppositories should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and direct sunlight. Do not store in extreme heat or humidity to maintain product stability.

Indometacin Mcc is supplied as a rectal suppository. The suppository is inserted into the rectum, typically after bowel movements, following the specific instructions provided by the healthcare professional to ensure proper absorption.

Serious risks include gastrointestinal ulceration or bleeding, acute renal impairment, severe liver injury, and hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should be monitored for signs of these conditions and seek immediate medical attention if they occur.

Indometacin Mcc should be avoided in individuals with known hypersensitivity to indometacin or other NSAIDs, active gastrointestinal ulcer or bleeding, severe renal or hepatic impairment, and in patients where NSAID use is contraindicated, such as certain cardiovascular conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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