Indometacine Aurobindo (Indometacin)

Indometacin works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the formation of prostaglandins from arachidonic acid. Lower prostaglandin levels reduce inflammation, pain signaling, and fever, providing symptomatic relief in acute and chronic inflammatory states.

The exact dose of Indometacine Aurobindo is set by the prescribing clinician based on the individual’s diagnosis, severity of symptoms, renal and hepatic function, and any concomitant medications. Dosage may be adjusted during treatment to achieve optimal therapeutic effect while minimizing adverse reactions.

The safety of indometacin in pregnancy and lactation has not been definitively established, and it is generally classified as contraindicated in the third trimester because of fetal risks. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative therapies with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Indometacin is a potent NSAID with a relatively strong COX inhibition profile, often providing faster pain relief in gout and severe arthritis compared with ibuprofen. However, it may carry a higher risk of gastrointestinal and renal side effects, so clinicians weigh efficacy against safety when choosing between agents.

Indometacine Aurobindo tablets should be stored at room temperature, below 25 °C, in the original packaging. Protect the product from moisture, direct sunlight and excessive heat to maintain stability throughout its shelf life.

The medication is taken orally, usually with a full glass of water. It can be taken with food or a milky drink to lessen gastrointestinal irritation, but patients should follow the specific instructions provided by their prescriber.

Serious adverse events include gastrointestinal ulceration or bleeding, acute kidney injury, severe hypersensitivity reactions such as Stevens‑Johnson syndrome, and cardiovascular complications like increased blood pressure or thrombotic events. Patients should seek immediate medical attention if they notice signs of bleeding, sudden renal dysfunction, or severe skin reactions.

Indometacine Aurobindo is contraindicated in individuals with known hypersensitivity to indometacin or other NSAIDs, those with active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and in the third trimester of pregnancy. Caution is also advised for patients with uncontrolled hypertension or heart failure.