Product image of Indoxyl (Clindamycin, Benzoyl Peroxide) supplied by GNH India

Indoxyl

Active Ingredient:
Clindamycin, Benzoyl Peroxide
Origin:
EU

Indoxyl (Clindamycin, Benzoyl Peroxide)

Clindamycin, the active ingredient in Indoxyl, is an antibiotic/keratolytic presented as a topical preparation for topical use. Formulated with benzoyl peroxide, it is indicated for the treatment of acne vulgaris in adolescents and adults. The combination reduces bacterial colonisation and keratin plug formation, helping to clear inflammatory and non‑inflammatory lesions. Indoxyl is marketed in the European Union as a prescription‑only product.

GNH India supplies Indoxyl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Trading Services Limited

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Indications & Clinical Uses

Indoxyl, containing clindamycin and benzoyl peroxide, is employed in the management of acne vulgaris, a disorder of the pilosebaceous unit.

  • Acne vulgaris (inflammatory lesions): reduces papules and pustules, leading to decreased redness.
  • Acne vulgaris (non‑inflammatory lesions): diminishes comedones and prevents new lesion formation.
  • Overall acne severity: improves skin appearance and reduces total lesion count.

How It Works

  • Clindamycin binds to the 50S ribosomal subunit of Cutibacterium acnes, inhibiting protein synthesis and bacterial proliferation. Benzoyl peroxide generates free radicals that oxidise bacterial proteins and lipids, providing a rapid bactericidal effect, while also exerting a keratolytic action that loosens corneocyte cohesion within follicles. The dual action decreases microbial load and follicular obstruction, facilitating lesion resolution.

Side Effects

Topical application of Indoxyl may be associated with local skin reactions and, rarely, systemic effects.

Common Side Effects

  • Skin irritation: mild redness or itching at the application site.
  • Dryness: peeling or flaking of the treated skin.
  • Burning sensation: transient warmth or stinging after application.
  • Scaling: increased skin desquamation.
  • Erythema: mild redness persisting for a short period.

Serious or Rare Side Effects

  • Contact dermatitis: severe allergic reaction with swelling and blistering.
  • Photosensitivity: heightened skin sensitivity to sunlight leading to sunburn.
  • Angioedema: rapid swelling of face, lips, or tongue.
  • Anaphylaxis: rare systemic allergic response requiring emergency care.

Precautions & Warnings

When using Indoxyl, certain precautions should be observed to minimise adverse reactions and ensure optimal efficacy.

  • Avoid application to damaged or inflamed skin: may increase irritation.
  • Limit use to the prescribed area: excessive coverage can heighten side‑effects.
  • Do not combine with other topical acne agents containing retinoids or salicylic acid without medical advice: risk of increased irritation.
  • Discontinue use if severe redness, swelling, or allergic signs develop: seek medical evaluation.
  • Use sunscreen and protective clothing: benzoyl peroxide can increase photosensitivity.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Indoxyl can interact with other topical or systemic agents, influencing its safety or effectiveness.

Major Interactions (Avoid)

  • Concurrent use of oral antibiotics for acne (e.g., tetracyclines): may increase risk of antibiotic resistance.
  • Topical retinoids applied simultaneously: heightened skin irritation.
  • Antifungal creams containing azoles: potential reduced efficacy of benzoyl peroxide.

Moderate Interactions (Monitor Closely)

  • Systemic isotretinoin therapy: monitor for excessive dryness or irritation.
  • Use with other keratolytic agents (e.g., salicylic acid): adjust frequency to avoid over‑exfoliation.
  • Application of cosmetic products containing alcohol or astringents: may exacerbate dryness.

Frequently Asked Questions

Indoxyl is a prescription‑only topical formulation that combines clindamycin and benzoyl peroxide to treat acne vulgaris. It targets both inflammatory and non‑inflammatory lesions, helping to reduce papules, pustules, and comedones while improving overall skin appearance in adolescents and adults.

Clindamycin in Indoxyl binds to the 50S subunit of bacterial ribosomes, specifically those of Cutibacterium acnes, blocking protein synthesis and halting bacterial growth. This antibacterial action reduces the microbial component that contributes to inflammation in acne lesions.

The dosage and frequency of Indoxyl are determined by the prescribing healthcare professional based on the severity of acne, patient age, and skin tolerance. Typically, a thin layer is applied to the affected area once or twice daily, but exact instructions must come from the prescriber.

Safety data for topical clindamycin/benzoyl peroxide during pregnancy and lactation are limited. The prescriber should weigh potential benefits against possible risks. If treatment is essential, it may be used under medical supervision, but alternative therapies are often considered first.

To order Indoxyl, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Indoxyl combines an antibiotic (clindamycin) with a keratolytic oxidising agent (benzoyl peroxide), offering both antibacterial and comedolytic actions in a single product. Compared with monotherapy agents such as retinoids or oral antibiotics, it can provide faster lesion clearance while reducing the risk of bacterial resistance associated with antibiotic‑only regimens.

Indoxyl should be stored below 25 °C in its original packaging, protected from moisture and direct light. Keep the container tightly closed when not in use and avoid exposing the product to extreme temperatures or humidity to maintain its stability.

Apply a thin, even layer of Indoxyl to clean, dry skin on the affected areas, usually once or twice daily as directed by the prescriber. Avoid contact with eyes, mouth and broken skin. Wash hands after application and refrain from using other potentially irritating topical products unless advised.

The most serious risks include severe allergic reactions such as contact dermatitis, angioedema, or anaphylaxis. Patients should discontinue use and seek immediate medical attention if they experience rapid swelling, blistering, difficulty breathing, or widespread rash.

Indoxyl should not be used by individuals with a known hypersensitivity to clindamycin, benzoyl peroxide, or any component of the formulation. It is also contraindicated on severely damaged, inflamed or infected skin until the underlying condition is resolved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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