Product image of Indren (Zolpidem Tartrate) supplied by GNH India

Indren

Active Ingredient:
Zolpidem Tartrate
Origin:
EU

Indren (Zolpidem Tartrate)

Zolpidem Tartrate, the active ingredient in Indren, is a non‑benzodiazepine hypnotic (Z‑drug) presented as an oral dosage form for oral use. It is indicated for the short‑term treatment of insomnia in adults. The medication works by enhancing GABA‑mediated inhibition, helping patients fall asleep faster and maintain sleep through the night.

GNH India supplies Indren as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with reliable quality assurance and regulatory compliance. Our distribution network ensures timely delivery to diverse healthcare settings.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Zolpidem Tartrate is used to treat insomnia by facilitating sleep initiation and maintenance.
  • Insomnia (sleep onset): reduces the time needed to fall asleep.
  • Insomnia (sleep maintenance): decreases the number of nocturnal awakenings.
  • Insomnia (overall sleep quality): increases total sleep time and improves sleep efficiency.

How It Works

  • Zolpidem Tartrate binds selectively to the benzodiazepine site of the GABA‑A receptor complex, acting as a positive allosteric modulator. This enhances the inhibitory effect of GABA, increasing chloride ion influx and hyperpolarizing neuronal membranes. The resulting potentiation of GABAergic neurotransmission reduces neuronal excitability in the central nervous system, promoting the onset of sleep without significantly affecting sleep architecture.

Side Effects

Zolpidem Tartrate may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Somnolence or daytime sleepiness
  • Nausea

Serious or Rare Side Effects

  • Complex sleep behaviors such as sleepwalking or driving while not fully awake
  • Allergic reactions including rash, swelling, or anaphylaxis
  • Mood changes including depression, anxiety, or suicidal thoughts

Precautions & Warnings

When prescribing Zolpidem Tartrate, several safety considerations should be observed.

  • Avoid use with alcohol: increased risk of profound central nervous system depression.
  • Use caution in hepatic impairment: reduced clearance may raise drug exposure.
  • Do not operate machinery or drive: residual sedation can impair performance the next day.
  • Pregnancy and lactation: consult a physician as safety data are limited.
  • Elderly patients: higher susceptibility to falls and cognitive impairment.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Zolpidem Tartrate can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Alcohol: additive CNS depression may cause severe sedation.
  • Other CNS depressants (e.g., benzodiazepines, opioids): risk of profound respiratory depression and profound sedation.
  • Strong CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin): can markedly increase zolpidem plasma concentrations.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (rifampin, carbamazepine, phenytoin): may reduce zolpidem levels and diminish efficacy.
  • Fluvoxamine: may modestly increase zolpidem exposure, requiring dose assessment.
  • Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine or sertraline: may enhance sedative effects.

Frequently Asked Questions

Indren contains zolpidem tartrate and is prescribed for the short‑term treatment of insomnia. It helps patients fall asleep more quickly and stay asleep through the night, improving overall sleep quality in adults who have difficulty initiating or maintaining sleep.

Zolpidem tartrate binds to the benzodiazepine site on the GABA‑A receptor, acting as a positive allosteric modulator. This increases the inhibitory effect of GABA, leading to greater chloride influx, neuronal hyperpolarisation, and reduced central nervous system activity, which facilitates sleep onset.

The appropriate dose of Indren is determined by the prescribing clinician based on the patient’s age, medical condition, and response to therapy. Dosage instructions are individualized and should be followed exactly as written on the prescription label.

Safety data for zolpidem tartrate in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against possible risks before prescribing Indren to pregnant or nursing women, and alternative treatments may be considered.

To place an order, submit an enquiry on the Indren product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indren (zolpidem tartrate) is a non‑benzodiazepine hypnotic that acts quickly to promote sleep with a relatively short half‑life, which may result in less next‑day drowsiness compared with many benzodiazepines. However, all hypnotics carry risks of dependence and complex sleep behaviours, so choice should be individualized.

Indren should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and heat sources to maintain its stability and potency throughout its shelf life.

Indren is taken orally, usually as a single dose immediately before bedtime. Patients should ensure they have a full night’s sleep opportunity (7‑8 hours) and should not consume alcohol or operate machinery after taking the medication.

Serious risks include complex sleep behaviours such as sleepwalking, driving or eating while not fully awake, as well as allergic reactions and mood changes like depression or suicidal thoughts. Any of these events require immediate medical attention and discontinuation of the drug.

Indren is contraindicated in patients with known hypersensitivity to zolpidem or any component of the formulation, in individuals with severe hepatic impairment, and in those who have a history of complex sleep behaviours. Caution is also advised for the elderly and for patients taking other central nervous system depressants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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