Product image of Inexium (Esomeprazole) supplied by GNH India

Inexium

Active Ingredient:
Esomeprazole
Origin:
EU

Inexium (Esomeprazole)

Esomeprazole, the active ingredient in Inexium, is a proton pump inhibitor presented as an intravenous solution for intravenous use. It provides rapid reduction of gastric acid secretion and is indicated for the treatment of gastro‑oesophageal reflux disease, erosive esophagitis and peptic ulcer disease, particularly in patients who cannot take oral therapy.

GNH India supplies Inexium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Laboratoires Grünenthal S.A.S.

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Indications & Clinical Uses

Esomeprazole is a proton pump inhibitor used to manage conditions associated with excess gastric acid.

  • Gastro‑oesophageal reflux disease (GERD): reduces acid exposure, relieving heartburn and regurgitation.
  • Erosive esophagitis: promotes healing of acid‑induced esophageal lesions.
  • Peptic ulcer disease: facilitates ulcer healing by maintaining a low‑acid gastric environment.

How It Works

  • Esomeprazole selectively and irreversibly binds to the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of gastric parietal cells. By inhibiting this final step of acid production, it markedly decreases basal and stimulated gastric acid secretion, leading to an increased gastric pH and reduced acidity in the stomach. The inhibition persists for the lifespan of the pump until new enzymes are synthesized.

Side Effects

Adverse reactions reported with intravenous esomeprazole are generally consistent with the class of proton pump inhibitors.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhoea: loose stools occurring during treatment.
  • Nausea: transient feeling of queasiness.
  • Injection site reactions: erythema or pain at the infusion site.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis associated with altered gut flora.
  • Acute interstitial nephritis: inflammation of kidney interstitium.
  • Anaphylaxis: life‑threatening allergic response.

Precautions & Warnings

When using intravenous esomeprazole, clinicians should observe several precautionary measures to ensure safety and efficacy.

  • Assess renal function: adjust use in patients with severe renal impairment.
  • Monitor electrolytes: watch for hypomagnesemia during prolonged therapy.
  • Evaluate for infection: consider risk of Clostridioides difficile colitis.
  • Use cautiously in pregnancy: limited data, weigh benefits against potential risks.
  • Store at ambient temperature: keep below 25 °C, protect from light and moisture in original packaging.

Avoid Interactions

Esomeprazole may alter the pharmacokinetics of several co‑administered medicines.

Major Interactions (Avoid)

  • Ketoconazole: reduced absorption leading to loss of antifungal efficacy.
  • Atazanavir: decreased plasma concentrations compromising HIV therapy.
  • Warfarin: potential increase in anticoagulant effect, requiring INR monitoring.

Moderate Interactions (Monitor Closely)

  • Clopidogrel: reduced activation may diminish antiplatelet activity.
  • Digoxin: increased serum levels may require dose adjustment.
  • Methotrexate: higher exposure can enhance toxicity, especially at high doses.

Frequently Asked Questions

Inexium, containing esomeprazole, is used to treat gastro‑oesophageal reflux disease, erosive esophagitis and peptic ulcer disease. It provides rapid acid suppression, which helps relieve symptoms and promotes healing of the gastrointestinal lining in patients who need intravenous therapy.

Esomeprazole works by binding irreversibly to the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the surface of parietal cells. This inhibition blocks the final step of acid production, leading to a sustained increase in gastric pH and reduced acidity.

The appropriate dose of Inexium is determined by the prescribing healthcare professional based on the patient’s condition, severity, and clinical response. Dosage regimens are individualized and should follow the prescriber’s instructions and local guidelines.

Safety data for esomeprazole in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order Inexium, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Inexium (esomeprazole) is the S‑enantiomer of omeprazole and generally provides more consistent plasma concentrations and a slightly higher bioavailability. Clinically, it offers comparable acid‑suppression efficacy to other PPIs, with a similar safety profile, but the choice often depends on formulation, dosing convenience and individual patient response.

Inexium should be stored at ambient temperature, below 25 °C. Keep the vials in their original packaging, protect them from moisture and direct light, and avoid freezing. Follow any additional handling instructions provided with the product.

Inexium is supplied as an intravenous solution and is administered by slow infusion into a vein under the supervision of qualified medical personnel. The infusion rate and duration are set by the prescribing clinician according to the patient’s therapeutic needs.

Serious risks include Clostridioides difficile‑associated colitis, acute interstitial nephritis, severe electrolyte disturbances such as hypomagnesemia, and rare allergic reactions like anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for signs of infection, renal impairment and allergic responses during therapy.

Inexium is contraindicated in patients with known hypersensitivity to esomeprazole, other proton pump inhibitors, or any component of the formulation. Caution is also advised for individuals with severe hepatic impairment, and it should be avoided in patients where rapid acid suppression is not indicated without a prescriber’s assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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