Product image of Infanrix-Ipv (Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid) supplied by GNH India

Infanrix-Ipv

Active Ingredient:
Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid
Origin:
EU

Infanrix-Ipv (Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid)

Diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed, inactivated poliovirus vaccine, the active ingredient in Infanrix-Ipv, is a preventive vaccine presented as an injectable solution for intramuscular use. It provides active immunization against diphtheria, tetanus, pertussis and poliomyelitis in infants and young children.

GNH India supplies Infanrix-Ipv as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Glaxosmithkline Biologicals S.A.

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Indications & Clinical Uses

Infanrix-Ipv is a combination vaccine that delivers active immunity against bacterial toxins and poliovirus infection.

  • Diphtheria: stimulates protective antibodies against diphtheria toxin.
  • Tetanus: stimulates protective antibodies against tetanus toxin.
  • Pertussis: stimulates protective antibodies against pertussis toxin, filamentous hemagglutinin and pertactin.
  • Poliomyelitis: stimulates protective antibodies against poliovirus serotypes 1, 2 and 3.

How It Works

  • The vaccine contains purified diphtheria and tetanus toxoids, acellular pertussis antigens (including pertussis toxin, filamentous hemagglutinin and pertactin) and inactivated poliovirus, all adsorbed onto aluminium hydroxide. The aluminium adjuvant enhances antigen presentation, prompting B‑cell and T‑cell activation that leads to the production of high‑affinity neutralising antibodies and memory cells, thereby conferring long‑lasting protective immunity.

Side Effects

Common adverse reactions are generally mild and transient.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or swelling: localized erythema or edema.
  • Fever: low‑grade temperature rise within 24‑48 hours.
  • Irritability: increased fussiness in infants.
  • Loss of appetite: temporary reduction in feeding.
  • Fatigue: mild tiredness post‑vaccination.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: rare neurologic events following vaccination.
  • High fever: temperature >40 °C persisting beyond 24 hours.
  • Prolonged crying: inconsolable crying lasting more than 3 hours.
  • Hypotonic‑hyporesponsive episode: transient loss of muscle tone.
  • Encephalopathy: very rare inflammatory brain condition.

Precautions & Warnings

Infanrix-Ipv should be administered according to national immunisation schedules and under professional supervision.

  • Age restriction: only for infants and children as specified by health authorities.
  • Hypersensitivity: avoid in individuals with known allergy to any vaccine component.
  • Immunodeficiency: use with caution in severely immunocompromised patients.
  • Schedule adherence: follow recommended dosing intervals to ensure optimal immunity.
  • Post‑vaccination monitoring: observe for at least 15 minutes for immediate reactions.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Vaccines may interact with other immunologic agents or therapies.

Major Interactions (Avoid)

  • Live attenuated vaccines: avoid administration within 4 weeks before or after Infanrix-Ipv.
  • Immunoglobulin therapy: postpone vaccination for at least 3 months after receipt.
  • Blood products: defer vaccination for 4 weeks following transfusion.
  • Severe immunosuppressive drugs: may reduce vaccine efficacy.
  • High‑dose steroids: may blunt immune response.

Moderate Interactions (Monitor Closely)

  • Antipyretics: may mask fever, monitor temperature independently.
  • Concurrent vaccines: increased reactogenicity may occur, observe for combined side effects.
  • Antibiotics: generally no effect, but monitor for unusual reactions.
  • Allergy medications: may reduce severity of hypersensitivity signs.
  • Chronic illnesses: assess individual risk‑benefit before vaccination.

Frequently Asked Questions

Infanrix-Ipv is a combination vaccine used to actively immunise infants and young children against diphtheria, tetanus, pertussis (whooping cough) and poliomyelitis. It provides protection by stimulating the body to produce antibodies against the toxins and viruses that cause these diseases.

The vaccine contains diphtheria and tetanus toxoids, acellular pertussis antigens and inactivated poliovirus, all adsorbed onto aluminium hydroxide. The aluminium acts as an adjuvant, enhancing antigen presentation and prompting the immune system to generate high‑affinity antibodies and memory cells that confer long‑lasting protection.

The dosing schedule for Infanrix-Ipv is determined by the prescribing healthcare professional based on national immunisation guidelines. Typically, a series of three primary doses is given in infancy, followed by booster doses, but the exact timing and number of doses are set by the clinician.

Infanrix-Ipv is generally not administered to pregnant women because it is a vaccine intended for infants. Women who are breastfeeding can receive the vaccine if indicated, but the decision should be made by a qualified healthcare provider after evaluating the benefits and any potential risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and necessary import documentation.

Infanrix-Ipv combines DTaP (diphtheria, tetanus, acellular pertussis) with IPV (inactivated poliovirus) in a single injection, reducing the number of shots required compared with separate DTaP and IPV vaccines. Its safety and immunogenicity profile is comparable to other licensed DTaP‑IPV products, while offering convenience for immunisation programmes.

Infanrix-Ipv must be stored refrigerated at 2‑8 °C. It should be kept in its original packaging, protected from light, and must never be frozen or shaken. Prior to administration, the vaccine should be allowed to reach room temperature briefly, but not exceed the recommended temperature range.

The vaccine is given as an intramuscular injection, usually into the anterolateral thigh in infants or the deltoid muscle in older children. Administration is performed by a qualified healthcare professional following aseptic technique and the recommended immunisation schedule.

Serious but rare risks include severe allergic reactions (anaphylaxis), seizures, high fever, prolonged crying episodes, hypotonic‑hyporesponsive episodes, and very rare cases of encephalopathy. Any signs of a severe reaction require immediate medical attention.

Infanrix-Ipv should not be given to individuals with a known severe allergy to any component of the vaccine, including aluminium hydroxide, or to those who have experienced a serious reaction to a previous dose. It is also contraindicated in children with severe immunodeficiency until evaluated by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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