Product image of Infanrix-Ipv (Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid) supplied by GNH India

Infanrix-Ipv

Active Ingredient:
Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid
Origin:
EU

Infanrix-Ipv (Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid)

Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxide, the active ingredient in Infanrix-Ipv, is a vaccine presented as an injectable solution for intramuscular use. It is used to prevent pertussis (whooping cough) in infants and children as part of routine immunisation programmes approved in the European Union.

GNH India supplies Infanrix-Ipv as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Biologicals S.A.

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Indications & Clinical Uses

Infanrix-Ipv is a pertussis vaccine that stimulates immunity against the bacterium responsible for whooping cough.

  • Prevention of pertussis: provides active immunisation against Bordetella pertussis in infants and young children.
  • Primary immunisation schedule: administered as part of the first series of childhood vaccines to establish early protection.
  • Booster dose: given later in childhood to maintain protective antibody levels.

How It Works

  • Infanrix-Ipv contains purified pertussis toxoid and pertactin proteins adsorbed onto aluminium hydroxide, an adjuvant that enhances immune recognition. After intramuscular injection, antigen‑presenting cells process these proteins, activating B‑cells and T‑helper cells, which generate specific antibodies against pertussis toxin and pertactin, thereby establishing active immunity.

Side Effects

Like all vaccines, Infanrix-Ipv may be associated with local and systemic reactions.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness at injection site: localized erythema that resolves within a few days.
  • Fever: low‑grade temperature rise occurring within 24‑48 hours.
  • Irritability: temporary fussiness or crying in infants.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: rare febrile convulsions following vaccination.
  • Persistent high fever: prolonged temperature above 40°C that may need evaluation.

Precautions & Warnings

Before administering Infanrix-Ipv, certain safety considerations should be observed.

  • Screen for severe allergy: assess history of hypersensitivity to vaccine components.
  • Delay vaccination: postpone if the child has a moderate or severe acute illness.
  • Observe after injection: monitor for at least 15 minutes for immediate reactions.
  • Contraindicated in known anaphylaxis to pertussis antigens.
  • Store at 2‑8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Infanrix-Ipv has limited pharmacological interactions, but certain co‑administrations require attention.

Major Interactions (Avoid)

  • Concurrent administration with other pertussis‑containing vaccines: may increase reactogenicity.
  • Use with immunoglobulin products: can diminish vaccine‑induced immunity.

Moderate Interactions (Monitor Closely)

  • Immunosuppressive therapy: may reduce the immune response to the vaccine.
  • Antipyretics (e.g., acetaminophen): may mask fever, a common post‑vaccination sign.
  • Blood products given shortly before or after vaccination: could interfere with antibody development.

Frequently Asked Questions

Infanrix-Ipv is a vaccine indicated for the prevention of pertussis, commonly known as whooping cough, in infants and young children. It is administered as part of routine childhood immunisation schedules to establish and maintain protective immunity against the Bordetella pertussis bacterium.

The pertussis toxoid is an inactivated form of the pertussis toxin that cannot cause disease. When adsorbed onto aluminium hydroxide, it acts as an antigen that stimulates the immune system to produce specific antibodies. These antibodies neutralise the toxin and help the body recognise and fight the actual pertussis bacteria if encountered.

The dose of Infanrix-Ipv is determined by the prescribing health professional according to national immunisation guidelines. Typically, it is given as a single intramuscular injection at specific ages within the infant vaccination schedule, with booster doses administered later as recommended.

Safety data for Infanrix-Ipv in pregnant women are limited, and it is generally not recommended unless the potential benefits outweigh any theoretical risks. Breastfeeding is not a contraindication; the vaccine can be administered to a lactating mother, but the infant should receive the vaccine directly according to the standard schedule.

To order Infanrix-Ipv, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, cold‑chain shipping details and any necessary import documentation.

Infanrix-Ipv contains both pertussis toxoid and pertactin antigens adsorbed on aluminium hydroxide, offering a broad immune response. Compared with monovalent pertussis vaccines, it may provide enhanced protection due to the additional pertactin component. However, reactogenicity can be slightly higher, which is typical for combination vaccines.

Infanrix-Ipv must be stored in a refrigerated environment between 2 °C and 8 °C. It should be kept in its original packaging to protect from light, and must never be frozen or shaken. If the cold chain is broken, the vaccine should be discarded according to local regulations.

Infanrix-Ipv is given as an intramuscular injection, usually into the anterolateral thigh of infants or the deltoid muscle of older children. The injection is performed by a qualified health professional using aseptic technique, and the site should be observed for any immediate adverse reactions.

The most serious risks, although rare, include severe allergic reactions such as anaphylaxis, febrile seizures, and persistent high fever that may require medical evaluation. Immediate medical attention is essential if signs of anaphylaxis (e.g., difficulty breathing, swelling of the face) occur after vaccination.

Infanrix-Ipv is contraindicated in individuals with a known severe allergy to any component of the vaccine, including the pertussis toxoid, pertactin or aluminium hydroxide. It should also be avoided in persons who have experienced a previous severe reaction to a pertussis‑containing vaccine. Consultation with a healthcare provider is advised for any uncertainty.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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