Product image of Infanrix-Ipv (Poliovirus (Inactivated) Type 3 (Saukett Strain), Pertussis Filamentous Haemagglutinin Adsorbed On A) supplied by GNH India

Infanrix-Ipv

Active Ingredient:
Poliovirus (Inactivated) Type 3 (Saukett Strain), Pertussis Filamentous Haemagglutinin Adsorbed On A
Origin:
EU

Infanrix-Ipv (Poliovirus (Inactivated) Type 3 (Saukett Strain), Pertussis Filamentous Haemagglutinin Adsorbed On A)

Poliovirus type 3 (inactivated) and pertussis filamentous haemagglutinin, the active ingredient in Infanrix-Ipv, is a vaccine presented as an injectable solution for intramuscular use. It induces active immunity to prevent poliomyelitis caused by poliovirus type 3 and pertussis (whooping cough) in infants and children.

GNH India supplies Infanrix-Ipv as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures timely delivery and compliance with cold‑chain requirements for vaccine integrity. We adhere to stringent quality standards and regulatory guidelines to support immunization programs across diverse regions.

Manufacturer / TM Owner

Glaxosmithkline Biologicals S.A.

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Indications & Clinical Uses

Infanrix-Ipv is a combination vaccine used in the prevention of viral and bacterial respiratory infections.

  • Poliomyelitis (type 3): provides immunity that prevents infection by poliovirus type 3.
  • Pertussis (whooping cough): stimulates protective antibodies against Bordetella pertussis.
  • Infants and young children: integrates dual protection into the routine childhood immunization schedule.

How It Works

  • Infanrix-Ipv works by presenting inactivated poliovirus type 3 antigens together with pertussis filamentous haemagglutinin to the immune system. These antigens are taken up by antigen‑presenting cells, leading to activation of B‑cells and T‑cells, production of specific antibodies, and development of cellular immunity that protects against subsequent exposure to the pathogens.

Side Effects

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or swelling: localized erythema or edema that resolves within a few days.
  • Low‑grade fever: transient temperature rise within 24‑48 hours.
  • Irritability: temporary fussiness in infants.
  • Decreased appetite: mild reduction in feeding after vaccination.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: febrile or non‑febrile convulsions following vaccination.
  • High fever (>40 °C): may indicate a systemic reaction.
  • Encephalopathy: rare inflammation of the brain.
  • Guillain‑Barré syndrome: extremely uncommon autoimmune neuropathy.

Precautions & Warnings

Before administering Infanrix-Ipv, consider the following precautions:

  • Severe allergy screening: do not give to individuals with known hypersensitivity to any vaccine component.
  • Acute illness: postpone vaccination if the patient has a moderate or severe febrile illness.
  • Febrile seizures: monitor infants closely for signs of seizures after immunization.
  • Live vaccine timing: avoid co‑administration with live attenuated vaccines unless specifically recommended.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Infanrix-Ipv may interact with other agents as follows:

Major Interactions (Avoid)

  • Live attenuated vaccines: avoid administering within 4 weeks before or after Infanrix-Ipv.
  • Immunoglobulins or blood products: may diminish the vaccine‑induced immune response.

Moderate Interactions (Monitor Closely)

  • Antipyretics (e.g., acetaminophen): can mask post‑vaccination fever, monitor temperature.
  • Immunosuppressive therapy: may reduce the effectiveness of the vaccine.
  • Pregnancy: no specific interaction, but consult healthcare provider before use.

Frequently Asked Questions

Infanrix-Ipv is a combination vaccine indicated for the prevention of poliomyelitis caused by poliovirus type 3 and pertussis (whooping cough). It is administered to infants and young children as part of routine immunization programs to provide dual protection against these infectious diseases.

The vaccine contains inactivated poliovirus type 3 antigens and pertussis filamentous haemagglutinin. When injected intramuscularly, these antigens are processed by antigen‑presenting cells, triggering B‑cell and T‑cell responses that generate specific antibodies and cellular immunity, thereby protecting the recipient from future infection.

The dosing schedule for Infanrix-Ipv is determined by the prescribing healthcare professional based on the patient’s age, immunization history, and local guidelines. The prescriber will specify the volume and timing of each injection to ensure optimal protection.

The safety of Infanrix-Ipv in pregnancy has not been definitively established, and it is generally recommended to vaccinate before pregnancy when possible. Breastfeeding is not a contraindication, but mothers should discuss any concerns with their healthcare provider.

To place an order, submit an enquiry on the Infanrix-Ipv product page at gnhindia.com, providing the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then replies with pricing, availability, shipping details (including cold‑chain logistics), and necessary import documentation.

Infanrix-Ipv combines inactivated poliovirus type 3 and pertussis haemagglutinin in a single injectable formulation, reducing the number of injections needed compared with separate vaccines. It meets EU regulatory standards and offers comparable immunogenicity to other licensed combination vaccines while simplifying the immunization schedule.

Infanrix-Ipv must be stored at 2‑8 °C (refrigerated) in its original packaging, protected from light. It should not be frozen or shaken. During transport, a validated cold‑chain system is required to maintain temperature stability until administration.

Infanrix-Ipv is given as an intramuscular injection, typically into the anterolateral thigh in infants or the deltoid muscle in older children. The injection is performed by a qualified healthcare professional following aseptic technique and the prescribed dosing schedule.

Serious adverse events, although rare, include anaphylaxis, seizures, high fever, encephalopathy, and Guillain‑Barré syndrome. Immediate medical attention is required if any signs of severe allergic reaction or neurological symptoms occur after vaccination.

Infanrix-Ipv should not be administered to individuals with a known severe allergy to any component of the vaccine, including the inactivated poliovirus or pertussis haemagglutinin. It is also contraindicated in persons who have experienced a previous severe reaction to a similar vaccine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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