Product image of Infanrix-Ipv (Poliovirus (Inactivated) Type 3 (Saukett Strain), Pertussis Filamentous Haemagglutinin Adsorbed On A) supplied by GNH India

Infanrix-Ipv

Active Ingredient:
Poliovirus (Inactivated) Type 3 (Saukett Strain), Pertussis Filamentous Haemagglutinin Adsorbed On A
Origin:
EU

Infanrix-Ipv (Poliovirus (Inactivated) Type 3 (Saukett Strain), Pertussis Filamentous Haemagglutinin Adsorbed On A)

Poliovirus (Inactivated) Type 3 (Saukett Strain), Pertussis Filamentous Haemagglutinin Adsorbed On A, the active ingredient in Infanrix-Ipv, is a vaccine presented as an injectable suspension for intramuscular use. It prevents diphtheria, tetanus, pertussis and poliomyelitis in infants and children.

GNH India supplies Infanrix-Ipv as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Smithkline Beecham Limited

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Indications & Clinical Uses

Infanrix-Ipv is a combination vaccine that protects against several bacterial and viral diseases in the pediatric population.

  • Diphtheria: induces immunity that prevents diphtheria infection.
  • Tetanus: stimulates antibodies that protect against tetanus toxin.
  • Pertussis (whooping cough): generates immunity to Bordetella pertussis.
  • Poliomyelitis: provides protection against poliovirus types 1, 2 and 3.

How It Works

  • Infanrix-Ipv contains inactivated poliovirus antigens and acellular pertussis components together with diphtheria and tetanus toxoids. After intramuscular injection, antigen‑presenting cells process these proteins, leading to activation of B‑cells and T‑cells that produce specific antibodies and memory cells, thereby establishing active immunity against each pathogen.

Side Effects

Common vaccine reactions are usually mild and transient.

Common Side Effects

  • Injection site pain: soreness at the injection site.
  • Redness or swelling: localized erythema.
  • Low‑grade fever: mild temperature rise within 24‑48 hours.
  • Irritability or crying: especially in infants.
  • Loss of appetite: temporary decrease in feeding.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: rare neurologic events post‑vaccination.
  • High fever (>40 °C): may be accompanied by rash.
  • Guillain‑Barré syndrome: extremely rare demyelinating disorder.
  • Encephalopathy: very rare inflammation of the brain.

Precautions & Warnings

Infanrix-Ipv should be administered according to national immunisation schedules and after evaluating individual health status.

  • Allergy assessment: verify no severe allergy to any vaccine component.
  • Acute illness: postpone vaccination if the child has a moderate or severe febrile illness.
  • Immunocompromised patients: consider reduced immunogenicity and consult a specialist.
  • Post‑vaccination monitoring: observe for at least 15 minutes for immediate reactions.
  • Concomitant vaccines: follow guidelines on spacing or co‑administration.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Vaccines may interact with other medicines or biologics, influencing immune response or safety.

Major Interactions (Avoid)

  • Immunoglobulin therapy: may neutralise vaccine antigens and reduce efficacy.
  • Blood products administered within 48 hours: can interfere with antibody formation.

Moderate Interactions (Monitor Closely)

  • Immunosuppressive drugs: may diminish immune response, requiring serologic testing.
  • Antipyretics taken prophylactically: could mask fever, but generally acceptable.
  • Live vaccines given concurrently: increase reactogenicity; schedule spacing as recommended.
  • Antibiotics: generally no effect, but severe infection may warrant postponement.

Frequently Asked Questions

Infanrix-Ipv is a combination vaccine indicated for the active immunisation of infants and children against diphtheria, tetanus, pertussis (whooping cough) and poliomyelitis caused by poliovirus types 1, 2 and 3. It is administered as part of routine childhood vaccination programmes to provide broad protection against these serious infectious diseases.

The vaccine contains inactivated poliovirus antigens and acellular pertussis components together with diphtheria and tetanus toxoids. After intramuscular injection, the antigens are taken up by antigen‑presenting cells, which stimulate B‑cells and T‑cells to produce specific antibodies and memory cells, establishing long‑lasting immunity against each pathogen.

The dosing schedule for Infanrix-Ipv is determined by national immunisation guidelines and the prescribing clinician. Typically, the vaccine is given as a series of intramuscular injections at specific ages in infancy, but the exact number of doses and timing are set by the health professional overseeing the child's vaccination plan.

Infanrix-Ipv is generally not administered to pregnant women because it is intended for infants. Breastfeeding mothers may receive the vaccine if indicated for their own protection, as the vaccine components are not known to be harmful to the infant. However, any vaccination during pregnancy or lactation should be discussed with a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and any necessary import documentation.

Infanrix-Ipv combines diphtheria, tetanus, acellular pertussis and inactivated poliovirus antigens in a single injection, reducing the number of separate shots required. Compared with separate monovalent vaccines, it simplifies the immunisation schedule and may improve compliance, while offering comparable safety and immunogenicity profiles as established in clinical studies.

Infanrix-Ipv must be stored refrigerated at 2‑8 °C. It should be kept in its original packaging, protected from light, and must not be frozen or shaken. Before administration, the vaccine should be allowed to reach room temperature for a short period, but any vial that appears cloudy or contains particles should be discarded.

The vaccine is supplied as an injectable suspension for intramuscular use. It is typically given into the anterolateral thigh muscle in infants or the deltoid muscle in older children, using a sterile needle and syringe. The injection should be performed by a qualified healthcare professional following aseptic technique.

Serious adverse events are rare but may include anaphylactic reactions, seizures, high fever, Guillain‑Barré syndrome, and encephalopathy. Immediate medical attention is required if signs of a severe allergic reaction (such as difficulty breathing, swelling of the face or throat) occur after vaccination.

Infanrix-Ipv should be avoided in individuals with a known severe allergy to any vaccine component, including the pertussis or poliovirus antigens. It is also contraindicated in persons who have experienced a severe reaction to a previous dose of the same vaccine. Consultation with a healthcare professional is essential for anyone with underlying medical conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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