Product image of Infanrix Ipv Hib (Diphtheria Toxoid, Tetanus Toxoid, Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate), ) supplied by GNH India

Infanrix Ipv Hib

Active Ingredient:
Diphtheria Toxoid, Tetanus Toxoid, Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate),
Origin:
EU

Infanrix Ipv Hib (Diphtheria Toxoid, Tetanus Toxoid, Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate),)

Diphtheria and tetanus toxoids, acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b conjugate vaccine, the active ingredient in Infanrix IPV Hib, is a vaccine presented as an injectable solution for intramuscular use. It induces immunity against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenzae type b disease in infants and young children.

GNH India supplies Infanrix IPV Hib as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Single Member A.E.B.E.

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Indications & Clinical Uses

Infanrix IPV Hib is a multivalent vaccine that targets several bacterial and viral pathogens commonly encountered in early childhood.

  • Diphtheria: provides protective immunity against diphtheria toxin in infants and toddlers.
  • Tetanus: induces antibodies that prevent tetanus toxin‑mediated disease.
  • Pertussis (whooping cough): reduces incidence and severity of pertussis infections.
  • Poliomyelitis: safeguards against poliovirus infection and paralytic disease.
  • Haemophilus influenzae type b: prevents invasive Hib disease such as meningitis and pneumonia.

How It Works

  • The vaccine contains purified toxoids of diphtheria and tetanus, acellular pertussis antigens, inactivated poliovirus particles, and a Hib capsular polysaccharide conjugated to tetanus toxoid. After intramuscular injection, antigen‑presenting cells process these components, stimulating B‑cell production of specific antibodies and T‑cell help, thereby establishing active, long‑lasting immunity against each pathogen.

Side Effects

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or swelling: localized erythema or edema.
  • Fever: low‑grade temperature elevation within 24‑48 hours.
  • Irritability: increased fussiness in infants.
  • Loss of appetite: temporary reduction in feeding.
  • Headache: mild headache reported in some recipients.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: rare neurologic events following vaccination.
  • High fever (>40 °C): may be accompanied by febrile seizures.
  • Apnea: especially in premature infants.
  • Guillain‑Barré syndrome: extremely rare demyelinating neuropathy.
  • Severe local reaction: necrosis or abscess formation at injection site.

Precautions & Warnings

Infanrix IPV Hib should be administered according to national immunization schedules and under professional supervision.

  • Age: give only to infants and children as recommended by health authorities.
  • Allergy: avoid if the patient has a known hypersensitivity to any vaccine component.
  • Immunocompromised status: use with caution; immune response may be reduced.
  • Concurrent vaccines: follow recommended intervals when co‑administering other vaccines.
  • Pregnancy: safety not established; consult a healthcare provider before use.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Vaccines may interact with other biologics or immunomodulating agents.

Major Interactions (Avoid)

  • Live viral vaccines: do not administer simultaneously with Infanrix IPV Hib.
  • Blood products containing immunoglobulins: may neutralize vaccine antigens.

Moderate Interactions (Monitor Closely)

  • Antipyretics (e.g., acetaminophen): may mask post‑vaccination fever.
  • Corticosteroids: high‑dose therapy could diminish antibody response.
  • Immunosuppressive drugs: may require timing adjustments to achieve optimal immunity.

Frequently Asked Questions

Infanrix IPV Hib is a combination vaccine used to protect infants and young children against five serious diseases: diphtheria, tetanus, pertussis (whooping cough), poliomyelitis, and Haemophilus influenzae type b (Hib) infections. It is administered as part of routine childhood immunization programs.

The vaccine contains toxoids of diphtheria and tetanus, acellular pertussis antigens, inactivated poliovirus, and a Hib polysaccharide linked to tetanus toxoid. These components stimulate the immune system to produce specific antibodies, creating active immunity that neutralizes the toxins and viruses if the child is later exposed.

The exact dose and schedule are determined by the prescribing healthcare professional based on national immunization guidelines. Typically, the vaccine is given as an intramuscular injection in a series of doses during infancy, but the prescriber sets the precise regimen.

Safety data for Infanrix IPV Hib in pregnant or breastfeeding women are limited. The vaccine is generally not recommended for routine use during pregnancy unless the benefit outweighs potential risks. Breastfeeding mothers should consult their healthcare provider before vaccination.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Infanrix IPV Hib combines five antigens into a single injection, reducing the number of separate shots compared with administering individual vaccines. This can simplify schedules and improve compliance, while providing comparable immunogenicity and safety profiles to the separate component vaccines.

The vaccine must be stored refrigerated at 2‑8 °C, protected from light, and must never be frozen or shaken. It should be kept in its original packaging until use to maintain potency and stability.

Infanrix IPV Hib is given as an intramuscular injection, usually into the anterolateral thigh of infants or the deltoid muscle of older children, according to the schedule recommended by health authorities.

Serious but rare risks include severe allergic reactions such as anaphylaxis, high‑grade fever that may lead to seizures, and very rare neurologic events like Guillain‑Barré syndrome. Any signs of a severe reaction require immediate medical evaluation.

Infants with a known severe allergy to any component of the vaccine, or those who have experienced a previous serious reaction to a dose of Infanrix IPV Hib, should not be vaccinated. Additionally, children with certain immunodeficiencies may need special consideration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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