Product image of Infanrix-Ipv+hib (Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate), Poliovirus (Inactivated) Type 3 (Sa) supplied by GNH India

Infanrix-Ipv+hib

Active Ingredient:
Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate), Poliovirus (Inactivated) Type 3 (Sa
Origin:
EU

Infanrix-Ipv+hib (Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate), Poliovirus (Inactivated) Type 3 (Sa)

Haemophilus influenzae type b conjugate vaccine (combined with diphtheria, tetanus, pertussis and inactivated poliovirus), the active ingredient in Infanrix-Ipv+hib, is a vaccine presented as a lyophilized powder for reconstitution and injectable suspension for intramuscular use. It induces active immunity against diphtheria, tetanus, pertussis, poliomyelitis and Hib disease in infants and young children.

GNH India supplies Infanrix-Ipv+hib as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Gmbh & Co. Kg

1
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Indications & Clinical Uses

Infanrix-Ipv+hib is a combination vaccine that protects against several bacterial and viral infections.

  • Diphtheria: provides immunity that prevents diphtheria infection in infants.
  • Tetanus: induces antibodies that protect against tetanus toxin.
  • Pertussis (whooping cough): stimulates immunity to reduce pertussis disease.
  • Poliomyelitis: generates protection against poliovirus type 3.
  • Haemophilus influenzae type b (Hib): prevents invasive Hib disease such as meningitis.

How It Works

  • The vaccine contains purified diphtheria toxoid, tetanus toxoid, acellular pertussis antigens, inactivated poliovirus type 3, and Hib capsular polysaccharide chemically linked to tetanus toxoid. After intramuscular injection, antigen‑presenting cells process these components, leading to activation of B‑cells and T‑cells and production of specific antibodies and memory cells that neutralize the respective toxins and pathogens.

Side Effects

Infanrix-Ipv+hib may be associated with local and systemic reactions typical of injectable vaccines.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or swelling: transient erythema or edema around the injection area.
  • Fever: low‑grade temperature rise within 24‑48 hours.
  • Irritability: increased fussiness in infants after vaccination.
  • Loss of appetite: temporary reduction in feeding.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): rapid onset of hives, airway swelling, or hypotension.
  • Seizures: febrile seizures occurring in the context of high fever.
  • Persistent high fever: fever lasting more than 48 hours.
  • Encephalopathy: rare inflammation of the brain.
  • Guillain‑Barré syndrome: very rare autoimmune neuropathy.

Precautions & Warnings

Before administering Infanrix-Ipv+hib, healthcare professionals should observe several precautions.

  • Contraindication: known severe allergy to any vaccine component or previous dose.
  • Precaution: moderate or severe acute illness may warrant postponement of vaccination.
  • Observation: monitor the patient for at least 15 minutes after injection for immediate reactions.
  • Immunocompromised patients: evaluate risk‑benefit, as response may be reduced.
  • Pregnancy: safety not established; vaccine generally not given to pregnant women unless benefits outweigh risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Infanrix-Ipv+hib can interact with other agents that affect immune response or cause hypersensitivity.

Major Interactions (Avoid)

  • Live attenuated vaccines: concurrent administration may reduce immune response to either vaccine.
  • Immunoglobulin or blood products: may interfere with vaccine efficacy if given within 2 weeks.

Moderate Interactions (Monitor Closely)

  • Antipyretics (acetaminophen, ibuprofen): may blunt antibody response if given prophylactically.
  • Corticosteroids or immunosuppressants: may diminish immunogenicity.
  • Antibiotics: generally no effect, but monitor for allergic cross‑reaction if penicillin allergy present.

Frequently Asked Questions

Infanrix IPV+Hib is a combination vaccine used to protect infants and young children against five serious diseases: diphtheria, tetanus, pertussis (whooping cough), poliomyelitis caused by poliovirus type 3, and invasive disease caused by Haemophilus influenzae type b.

The vaccine contains toxoid and antigen components that are recognized by the immune system. After intramuscular injection, antigen‑presenting cells process the toxoids, pertussis proteins, inactivated poliovirus, and Hib polysaccharide‑tetanus toxoid conjugate, prompting B‑cell and T‑cell activation and the production of protective antibodies and memory cells.

The dosing schedule for Infanrix IPV+Hib is determined by the prescribing healthcare professional based on national immunization guidelines. The vaccine is typically administered as a series of intramuscular injections in the thigh or deltoid muscle at specific ages, but exact timing and number of doses should be set by the prescriber.

Safety data for Infanrix IPV+Hib in pregnant women are limited, and the vaccine is generally not recommended during pregnancy unless the potential benefit outweighs any risk. Limited information is available for breastfeeding; however, inactivated vaccines are not expected to pose a risk to the infant. Consultation with a healthcare provider is essential.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics) and any required import documentation.

Infanrix IPV+Hib combines diphtheria, tetanus, acellular pertussis, inactivated poliovirus type 3 and Hib conjugate in a single injection, reducing the number of separate shots. Alternatives such as Pentacel or Pediacel provide similar protection but may differ in poliovirus serotype coverage or Hib conjugate formulation. Choice depends on national schedules, availability and clinician preference.

The vaccine must be stored refrigerated at 2 °C to 8 °C. It should be kept in the original packaging, protected from light, and must not be frozen or shaken. Before use, the lyophilized powder is reconstituted with the supplied diluent and used promptly according to the product label.

Infanrix IPV+Hib is given by intramuscular injection, usually into the anterolateral thigh for infants or the deltoid muscle for older children. The reconstituted suspension is drawn into a sterile syringe and administered by a qualified healthcare professional following aseptic technique.

Serious adverse events are rare but can include severe allergic reactions (anaphylaxis), febrile seizures, persistent high fever, encephalopathy, and Guillain‑Barré syndrome. Immediate medical attention is required if signs of anaphylaxis (e.g., difficulty breathing, swelling of the face) or prolonged high fever occur after vaccination.

Infanrix IPV+Hib should not be given to individuals with a known severe allergy to any vaccine component or to a previous dose of the vaccine. It is also contraindicated in persons who have experienced a severe reaction to a prior dose of any diphtheria, tetanus, pertussis, poliovirus or Hib vaccine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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