Product image of Infanrix-Ipv+hib (Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate), Poliovirus (Inactivated) Type 3 (Sa) supplied by GNH India

Infanrix-Ipv+hib

Active Ingredient:
Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate), Poliovirus (Inactivated) Type 3 (Sa
Origin:
EU

Infanrix-Ipv+hib (Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate), Poliovirus (Inactivated) Type 3 (Sa)

Haemophilus influenzae type b conjugate vaccine (tetanus toxoid conjugate) and inactivated poliovirus type 3, the active ingredients in Infanrix‑Ipv+Hib, are vaccines presented as an injectable solution for intramuscular use. They protect infants and children against diphtheria, tetanus, pertussis, poliomyelitis and Hib disease.

GNH India supplies Infanrix‑Ipv+Hib as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Biologicals S.A.

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Indications & Clinical Uses

Infanrix‑Ipv+Hib is a combination vaccine that targets bacterial and viral pathogens responsible for serious childhood infections.

  • Diphtheria: induces protective antibodies against diphtheria toxin.
  • Tetanus: stimulates immunity to tetanus toxin.
  • Pertussis: prevents whooping cough by generating antibodies to pertussis antigens.
  • Poliomyelitis: provides immunity to poliovirus types 1‑3.
  • Haemophilus influenzae type b: prevents invasive Hib disease by targeting the capsular polysaccharide.

How It Works

  • The vaccine contains diphtheria and tetanus toxoids, acellular pertussis antigens, inactivated poliovirus types 1‑3, and Haemophilus influenzae type b capsular polysaccharide conjugated to tetanus toxoid. After intramuscular injection, antigen‑presenting cells process these components, leading to B‑cell activation and production of specific antibodies that neutralize the respective toxins and pathogens, establishing active, long‑lasting immunity.

Side Effects

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or swelling: localized erythema or edema.
  • Fever: low‑grade temperature rise within 24‑48 hours.
  • Irritability: increased fussiness in infants.
  • Loss of appetite: temporary decrease in feeding.
  • Headache: mild headache reported in some recipients.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: rare occurrence, especially in febrile infants.
  • High fever (>40 °C): may indicate systemic reaction.
  • Severe allergic reaction: including angioedema or urticaria.
  • Guillain‑Barré syndrome: extremely rare demyelinating disorder.
  • Persistent neurological symptoms: prolonged irritability or abnormal movements.

Precautions & Warnings

Infanrix‑Ipv+Hib should be administered according to national immunisation schedules and under professional supervision.

  • Contraindication: severe allergic reaction to any vaccine component.
  • Postpone vaccination: moderate or severe acute illness with fever.
  • Monitor: observe for fever or local reactions for at least 15 minutes post‑injection.
  • Caution: use with care in immunocompromised children, as response may be reduced.
  • Avoid: simultaneous administration with live vaccines within 4 weeks.
  • Store at 2-8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Infanrix‑Ipv+Hib may interact with other agents that affect immune response.

Major Interactions (Avoid)

  • Immunoglobulin therapy: can diminish vaccine‑induced immunity.
  • Live vaccines given within 4 weeks: may interfere with immune response.
  • High‑dose steroids or immunosuppressants: may reduce antibody production.

Moderate Interactions (Monitor Closely)

  • Antipyretics (e.g., acetaminophen): may mask post‑vaccination fever.
  • Concurrent injectable vaccines: generally safe but monitor for increased reactogenicity.

Frequently Asked Questions

Infanrix‑Ipv+Hib is a combination vaccine used to protect infants and young children against five serious diseases: diphtheria, tetanus, pertussis (whooping cough), poliomyelitis (polio) and invasive disease caused by Haemophilus influenzae type b.

The vaccine contains toxoid and protein antigens that stimulate the immune system to produce specific antibodies. The Hib component uses a tetanus toxoid carrier to enhance the response to the bacterial polysaccharide, while the inactivated poliovirus provides viral antigens that trigger protective immunity without causing disease.

The dosing schedule, including the number of doses and timing, is determined by the prescribing clinician based on national immunisation guidelines and the child’s age and health status. No specific regimen is provided here.

Safety data for use during pregnancy are limited, and the vaccine is generally not recommended for pregnant women unless the benefit outweighs potential risk. Breastfeeding is not a contraindication, but the decision should be made in consultation with a healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and necessary import documentation.

Infanrix‑Ipv+Hib combines five antigens in a single injection, reducing the number of visits compared with separate vaccines. It offers comparable immunogenicity to other licensed pentavalent formulations while maintaining a well‑characterised safety profile.

The vaccine must be stored refrigerated at 2‑8 °C, protected from light, and must never be frozen or shaken. It should be kept in the original packaging until use to maintain potency.

Infanrix‑Ipv+Hib is given as an intramuscular injection, typically into the anterolateral thigh of infants. The injection should be performed by a qualified healthcare professional using aseptic technique.

Serious adverse events are rare but can include anaphylaxis, severe allergic reactions, high‑grade fever, seizures, and, very rarely, Guillain‑Barré syndrome. Immediate medical attention is required if any of these symptoms occur after vaccination.

Individuals with a known severe allergy to any component of the vaccine, or who have experienced a previous severe reaction to a dose of this vaccine, should not receive it. Children with moderate or severe acute illness should defer vaccination until recovery.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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