Product image of Infanrix (Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid) supplied by GNH India

Infanrix

Active Ingredient:
Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid
Origin:
EU

Infanrix (Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid)

Pertussis Toxoid and Pertactin (adsorbed on aluminium hydroxide), the active ingredient in Infanrix, is a preventive vaccine presented as an injectable formulation for intramuscular use. It is intended to protect infants and children against pertussis (whooping cough) by inducing an immune response that generates protective antibodies.

GNH India supplies Infanrix as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Glaxosmithkline Biologicals S.A.

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Indications & Clinical Uses

Infanrix is a preventive vaccine that targets the pertussis bacterium and is used within routine childhood immunisation programmes.

  • Infants (6 weeks – 6 months): Provides primary immunisation against pertussis.
  • Children (12‑15 months): Boosts immunity as part of the combined DTPa schedule.
  • Early childhood (4‑6 years): Maintains protection before school entry.

How It Works

  • Infanrix contains purified pertussis toxoid and pertactin proteins adsorbed onto aluminium hydroxide. After intramuscular injection, these antigens are taken up by antigen‑presenting cells, stimulating B‑cell and T‑cell responses that lead to the production of specific antibodies and cellular immunity, thereby conferring protection against Bordetella pertussis infection.

Side Effects

Infanrix may cause local and systemic reactions following injection.

Common Side Effects

  • Pain at injection site: mild to moderate discomfort.
  • Redness or swelling: localized erythema.
  • Fever: low‑grade temperature rise.
  • Irritability: temporary fussiness in infants.
  • Loss of appetite: reduced feeding for a short period.
  • Headache: mild headache in older children.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: febrile or non‑febrile convulsions.
  • Persistent high fever: temperature >40 °C lasting more than 24 hours.
  • Hypotonic‑hyporesponsive episode: reduced muscle tone and responsiveness.
  • Severe local reaction: extensive swelling or necrosis.
  • Guillain‑Barré syndrome: rare autoimmune neuropathy.

Precautions & Warnings

Infanrix should be administered according to national immunisation guidelines and with attention to individual health status.

  • Age restriction: not for infants younger than 6 weeks.
  • Allergy: avoid if known hypersensitivity to any vaccine component.
  • Acute illness: defer vaccination during moderate or severe febrile illness.
  • Immunocompromised: consult a physician before administration.
  • Concomitant vaccines: follow recommended spacing when given with other injectable vaccines.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Vaccines can interact with other agents that modify immune response.

Major Interactions (Avoid)

  • Live bacterial vaccines given simultaneously: may reduce efficacy of each product.
  • High‑dose immunoglobulin therapy within 2 weeks: can neutralise vaccine antigens.

Moderate Interactions (Monitor Closely)

  • Antipyretics taken prophylactically: may blunt antibody response.
  • Corticosteroids or immunosuppressants: may diminish immunogenicity.
  • Blood products administered shortly before or after vaccination: could affect antibody development.

Frequently Asked Questions

Infanrix is a preventive vaccine indicated for the immunisation of infants and children against pertussis (whooping cough). It is administered as part of routine childhood vaccination schedules to establish and maintain protective immunity against the Bordetella pertussis bacterium.

The active ingredients—pertussis toxoid and pertactin adsorbed on aluminium hydroxide—present key bacterial antigens to the immune system. This stimulates B‑cells and T‑cells to produce specific antibodies and cellular responses, creating long‑lasting protection against pertussis infection.

The dosage and schedule of Infanrix are determined by the prescribing clinician and follow national immunisation guidelines. Typically, the vaccine is given as a series of intramuscular injections at specific ages, but the exact regimen should be set by a qualified health professional.

Infanrix is generally not administered to pregnant women; instead, maternal pertussis vaccination is performed with a different formulation. Breastfeeding mothers may receive the vaccine if indicated for their child, but they should discuss any concerns with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and necessary import documentation.

Infanrix contains both pertussis toxoid and pertactin antigens, offering a broad immune response. Compared with vaccines that contain only toxoid, Infanrix may provide enhanced protection, especially in regions where pertactin‑deficient strains are prevalent. Clinical choice depends on local guidelines and availability.

Infanrix must be stored refrigerated at 2‑8 °C. It should be kept in its original packaging, protected from light, and must never be frozen or shaken. Proper cold‑chain management is essential to maintain vaccine potency until administration.

Infanrix is given by intramuscular injection, usually into the anterolateral thigh in infants and young children. The injection is performed by a qualified healthcare professional using aseptic technique, following the recommended schedule for primary and booster doses.

The most serious adverse events reported with Infanrix include severe allergic reactions such as anaphylaxis, high‑grade fever, seizures, and rare neurological conditions like Guillain‑Barré syndrome. Any signs of a serious reaction require immediate medical evaluation.

Infanrix should not be given to individuals with a known severe allergy to any vaccine component, including aluminium hydroxide, or to infants younger than 6 weeks. Persons with a history of severe vaccine‑related reactions should consult a healthcare professional before vaccination.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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