Product image of Infanrix Polio (Pertussis Filamentous Haemagglutinin Adsorbed On Aluminium Hydroxide, Hydrated, Pertussis Toxoid Ads) supplied by GNH India

Infanrix Polio

Active Ingredient:
Pertussis Filamentous Haemagglutinin Adsorbed On Aluminium Hydroxide, Hydrated, Pertussis Toxoid Ads
Origin:
EU

Infanrix Polio (Pertussis Filamentous Haemagglutinin Adsorbed On Aluminium Hydroxide, Hydrated, Pertussis Toxoid Ads)

Diphtheria and tetanus toxoids and acellular pertussis adsorbed, combined with inactivated poliovirus vaccine, the active ingredient in Infanrix Polio, is a prophylactic vaccine presented as an injectable solution for intramuscular use. It is indicated for the prevention of diphtheria, tetanus, pertussis (whooping cough) and poliomyelitis in infants and young children.

GNH India supplies Infanrix Polio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Biologicals S.A.

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Indications & Clinical Uses

Infanrix Polio is a combination vaccine that targets bacterial toxins and viral particles to provide active immunity against several childhood diseases.

  • Diphtheria: induces protective antibodies that neutralize diphtheria toxin.
  • Tetanus: stimulates immunity that prevents tetanus toxin effects.
  • Pertussis: generates antibodies against pertussis antigens, reducing whooping cough incidence.
  • Poliomyelitis: elicits immunity to inactivated poliovirus types 1, 2 and 3, preventing paralytic disease.

How It Works

  • The vaccine contains diphtheria and tetanus toxoids, acellular pertussis antigens (filamentous haemagglutinin and pertussis toxoid) adsorbed on aluminium hydroxide, and inactivated poliovirus types 1‑3. After intramuscular injection, these components are taken up by antigen‑presenting cells, prompting B‑cell and T‑cell activation and the production of specific antibodies that neutralize the respective toxins and viruses.

Side Effects

Common Side Effects

  • Pain at the injection site: mild to moderate discomfort.
  • Redness or swelling: localized inflammatory reaction.
  • Fever: low‑grade temperature rise within 24‑48 hours.
  • Irritability or crying: especially in infants.
  • Loss of appetite: temporary reduction in feeding.
  • Headache: mild, self‑limiting.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: rare neurologic events post‑vaccination.
  • High fever (>40 °C): may indicate systemic response.
  • Prolonged crying episodes: could signal discomfort or rare neurologic involvement.
  • Hypotonic‑hyporesponsive episode: transient loss of muscle tone.
  • Encephalopathy: extremely rare central nervous system complication.

Precautions & Warnings

Before administration, consider the following precautions:

  • Allergy screening: avoid in individuals with known hypersensitivity to any vaccine component.
  • Immediate observation: monitor the recipient for at least 15 minutes for acute reactions.
  • Acute illness: postpone vaccination if the child has a moderate or severe febrile illness.
  • Age limits: follow the recommended immunisation schedule; do not give to infants younger than the approved age.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Vaccines can interact with other agents that modify immune responses.

Major Interactions (Avoid)

  • Live attenuated vaccines given concurrently: may reduce the immune response to one or both products.
  • Immunoglobulin therapy administered within two weeks: can neutralise vaccine antigens.

Moderate Interactions (Monitor Closely)

  • Prophylactic antipyretics (acetaminophen, ibuprofen): may blunt antibody production if given routinely.
  • Corticosteroids or other immunosuppressants: may diminish vaccine efficacy.
  • Pregnancy: limited safety data; use only when benefits outweigh potential risks.

Frequently Asked Questions

Infanrix Polio is a combination vaccine used to prevent four serious infectious diseases in children: diphtheria, tetanus, pertussis (whooping cough) and poliomyelitis. It is administered according to national immunisation schedules to provide active immunity against the toxins and viruses that cause these illnesses.

The vaccine contains diphtheria and tetanus toxoids, acellular pertussis antigens (filamentous haemagglutinin and pertussis toxoid) adsorbed on aluminium hydroxide, and inactivated poliovirus types 1‑3. These components stimulate the immune system to produce specific antibodies that neutralise the bacterial toxins and poliovirus, establishing long‑lasting protection.

The dose and schedule of Infanrix Polio are determined by the prescribing clinician based on the approved immunisation timetable for the region. Typically, the vaccine is given as a series of intramuscular injections at specific ages, but exact timing and volume are set by the healthcare professional.

Safety data for Infanrix Polio in pregnant or breastfeeding women are limited. The vaccine is generally not recommended for routine use during pregnancy unless the potential benefit to the mother outweighs any theoretical risk to the fetus. Breastfeeding is not a contraindication, but clinicians should assess each case individually.

To order Infanrix Polio, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, cold‑chain shipping details and any necessary import documentation.

Infanrix Polio combines DTPa (diphtheria, tetanus, acellular pertussis) with IPV (inactivated poliovirus) in a single injection, reducing the number of shots compared with administering separate DTPa and IPV vaccines. Alternative products such as Pentacel also provide DTPa‑IPV but may differ in antigen concentrations or adjuvant composition, which can affect immunogenicity and reactogenicity profiles.

Infanrix Polio must be stored at 2‑8 °C (refrigerated) and protected from light. The vaccine should never be frozen or shaken. Vials should be kept in their original packaging until use, and any unused portion should be discarded according to local regulations after the recommended in‑use time.

The vaccine is given by intramuscular injection, usually into the anterolateral thigh for infants and young children. The administration technique follows standard aseptic procedures, and the injection site should be observed for local reactions after the dose is given.

The most serious adverse events reported with Infanrix Polio include severe allergic reactions such as anaphylaxis, high‑grade fever, seizures, and rare neurologic complications like encephalopathy or hypotonic‑hyporesponsive episodes. Any signs of a serious reaction require immediate medical evaluation.

Infanrix Polio should not be given to individuals with a known severe allergy to any vaccine component, including the aluminium adjuvant. It is also contraindicated in persons who have experienced a previous severe reaction to a DTPa‑IPV vaccine. Clinicians should assess each patient’s medical history before vaccination.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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