Product image of Infanrix Polio (Pertussis Filamentous Haemagglutinin Adsorbed On Aluminium Hydroxide, Hydrated, Pertussis Toxoid Ads) supplied by GNH India

Infanrix Polio

Active Ingredient:
Pertussis Filamentous Haemagglutinin Adsorbed On Aluminium Hydroxide, Hydrated, Pertussis Toxoid Ads
Origin:
EU

Infanrix Polio (Pertussis Filamentous Haemagglutinin Adsorbed On Aluminium Hydroxide, Hydrated, Pertussis Toxoid Ads)

Pertussis Filamentous Haemagglutinin, the active ingredient in Infanrix Polio, is a vaccine presented as an injectable solution for intramuscular use. It provides active immunity against diphtheria, tetanus, pertussis, and poliomyelitis in infants and young children.

GNH India supplies Infanrix Polio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Glaxosmithkline As

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Indications & Clinical Uses

Infanrix Polio is a combination vaccine that targets bacterial and viral pathogens responsible for diphtheria, tetanus, pertussis, and poliomyelitis.

  • Diphtheria: induces protective antibodies to prevent diphtheria infection.
  • Tetanus: stimulates immunity that blocks tetanus toxin effects.
  • Pertussis: generates antibodies against pertussis antigens to reduce severe coughing illness.
  • Poliomyelitis: creates immunity that prevents poliovirus replication and paralysis.

How It Works

  • Infanrix Polio contains purified diphtheria toxoid, tetanus toxoid, acellular pertussis antigens (including filamentous haemagglutinin adsorbed on aluminium hydroxide) and inactivated poliovirus. After intramuscular injection, these antigens are taken up by antigen‑presenting cells, prompting B‑cell antibody production and T‑cell activation, thereby establishing active, long‑lasting immunity against each pathogen.

Side Effects

Common Side Effects

  • Injection site pain: mild soreness at the injection site.
  • Redness or swelling: localized skin reaction.
  • Fever: low‑grade temperature rise within 24‑48 hours.
  • Irritability: temporary fussiness in infants.
  • Loss of appetite: reduced feeding for a short period.
  • Headache: mild headache reported by some recipients.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: rare neurologic event following vaccination.
  • High fever: temperature above 40°C that may need treatment.
  • Prolonged crying: excessive crying lasting more than three hours.
  • Guillain‑Barré syndrome: extremely rare autoimmune neuropathy.
  • Hypotonic‑hyporesponsive episodes: transient loss of muscle tone in infants.

Precautions & Warnings

Infanrix Polio should be administered according to national immunisation schedules for infants and children.

  • Allergy: avoid if the patient has a severe allergic reaction to any vaccine component.
  • Acute illness: postpone vaccination during moderate or severe febrile illness.
  • Immunocompromised: consult a healthcare professional before use.
  • Concurrent vaccines: may be given with other vaccines as per guidelines.
  • Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Infanrix Polio may interact with other agents that affect immune response.

Major Interactions (Avoid)

  • Live attenuated vaccines: avoid simultaneous administration with oral polio vaccine.
  • Immunoglobulins or blood products: may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Antipyretics: can mask post‑vaccination fever.
  • Corticosteroids: may blunt immune response when given in high doses.
  • Antibiotics: generally no effect, but monitor if high‑dose therapy is ongoing.

Frequently Asked Questions

Infanrix Polio is a combination vaccine used to prevent four serious diseases: diphtheria, tetanus, pertussis (whooping cough), and poliomyelitis. It is administered to infants and young children as part of routine immunisation programmes to establish long‑term protective immunity against these bacterial and viral infections.

Pertussis Filamentous Haemagglutinin is an acellular pertussis antigen adsorbed onto aluminium hydroxide. When injected, it is recognized by the immune system, prompting antigen‑presenting cells to activate B‑cells and T‑cells. This leads to the production of specific antibodies and cellular immunity that neutralise the pertussis bacterium.

The dosage and schedule of Infanrix Polio are determined by the prescribing healthcare professional based on national immunisation guidelines. Typically, the vaccine is given as a series of intramuscular injections at specific ages, but the exact timing and number of doses are set by the child's physician.

Infanrix Polio is generally not recommended for use in pregnant women unless the potential benefit outweighs any risk, as safety data are limited. Breastfeeding is not a contraindication, but mothers should discuss vaccination with their healthcare provider to assess individual circumstances.

To order Infanrix Polio, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The team then replies with pricing, availability, cold‑chain shipping details and any required import documentation.

Infanrix Polio is comparable to other DTaP‑IPV vaccines such as Pentacel or Pediarix, offering protection against the same four pathogens. Differences may include specific antigen formulations, adjuvant types, and approved age schedules. Clinicians choose a product based on national guidelines, availability, and individual patient considerations.

Infanrix Polio must be stored refrigerated at 2‑8 °C (36‑46 °F). It should be kept in its original packaging, protected from light, and must never be frozen or shaken. Prior to administration, the vial should be inspected for particulate matter and used within the time frame indicated by the manufacturer.

Infanrix Polio is given as an intramuscular injection, usually into the anterolateral thigh of infants or the deltoid muscle of older children. The injection is performed by a qualified healthcare professional following the recommended immunisation schedule, and the site should be observed for any immediate reactions.

The most serious adverse events reported with Infanrix Polio include anaphylactic reactions, seizures, high‑grade fever, and, rarely, Guillain‑Barré syndrome. Any signs of severe allergic response—such as difficulty breathing, swelling of the face or throat, or rapid heartbeat—require immediate medical attention.

Infanrix Polio should not be given to individuals with a known severe allergy to any component of the vaccine, including aluminium hydroxide or the pertussis antigens. It is also contraindicated in persons who have experienced a previous anaphylactic reaction to a DTaP‑IPV vaccine. Consultation with a healthcare provider is essential for anyone with a history of severe neurological disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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