Product image of Infanrix Polio (Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid) supplied by GNH India

Infanrix Polio

Active Ingredient:
Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid
Origin:
EU

Infanrix Polio (Pertussis Toxoid Adsorbed On Aluminium Hydroxide, Pertussis Pertactin Adsorbed On Aluminium Hydroxid)

Pertussis Toxoid Adsorbed on Aluminium Hydroxide and Pertussis Pertactin Adsorbed on Aluminium Hydroxide, the active ingredients in Infanrix Polio, are vaccine components presented as a combination diphtheria, tetanus, pertussis and poliomyelitis vaccine for intramuscular use. They stimulate active immunity against diphtheria toxin, tetanus toxin, pertussis antigens, and poliovirus, helping prevent these infections in infants and children.

GNH India supplies Infanrix Polio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Biologicals S.A.

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Indications & Clinical Uses

Infanrix Polio is a combination vaccine that targets bacterial toxins and poliovirus to prevent several childhood diseases.

  • Diphtheria: provides active immunity to prevent diphtheria infection.
  • Tetanus: induces antibodies that protect against tetanus toxin.
  • Pertussis (whooping cough): stimulates protection against Bordetella pertussis.
  • Poliomyelitis: generates immunity that blocks poliovirus replication.

How It Works

  • Infanrix Polio contains inactivated diphtheria and tetanus toxoids, pertussis antigens (toxoid and pertactin) adsorbed on aluminium hydroxide, and inactivated poliovirus strains. After intramuscular injection, these components are taken up by antigen‑presenting cells, prompting the immune system to produce specific antibodies and memory cells that neutralize the respective toxins and virus, thereby establishing active, long‑lasting protection.

Side Effects

Common Side Effects

  • Injection site pain, redness or swelling.
  • Low‑grade fever.
  • Irritability or fussiness in infants.
  • Decreased appetite.
  • Mild rash at the injection site.

Serious or Rare Side Effects

  • Anaphylactic reaction (severe allergic response).
  • Seizures or high‑grade fever.
  • Prolonged crying episodes.
  • Hypotonic‑hyporesponsive episodes.
  • Encephalopathy or neurologic complications.
  • Severe local inflammation requiring medical attention.

Precautions & Warnings

Infanrix Polio should be administered according to national immunisation schedules and under professional supervision.

  • Age: give only to infants and children as recommended by health authorities.
  • Allergy: avoid if the patient has a known hypersensitivity to any vaccine component.
  • Medical conditions: consult a healthcare provider for children with severe immunodeficiency.
  • Concurrent vaccines: can be co‑administered with other routine vaccines following guideline timing.
  • Pregnancy: not indicated for pregnant women; discuss risks with a clinician.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Infanrix Polio may interact with other agents that affect immune response.

Major Interactions (Avoid)

  • Live attenuated vaccines: avoid simultaneous administration.
  • Immunoglobulins: may reduce vaccine efficacy if given within two weeks.
  • Blood products: can interfere with immune response if administered shortly before or after vaccination.

Moderate Interactions (Monitor Closely)

  • Antipyretics: may mask post‑vaccination fever.
  • High‑dose corticosteroids: could diminish antibody production.
  • Other vaccines: schedule spacing as per immunisation guidelines.

Frequently Asked Questions

Infanrix Polio is a combination vaccine used to prevent four serious infectious diseases—diphtheria, tetanus, pertussis (whooping cough) and poliomyelitis—in infants and young children as part of routine immunisation programmes.

The vaccine contains inactivated diphtheria and tetanus toxoids, pertussis antigens (toxoid and pertactin) bound to aluminium hydroxide, and inactivated poliovirus. These components stimulate the immune system to produce specific antibodies and memory cells that neutralise the toxins and block poliovirus infection.

The dose and schedule are determined by the prescribing healthcare professional based on national immunisation guidelines. Typically, the vaccine is given as a series of intramuscular injections at specific ages, but the exact regimen must be set by the clinician.

Infanrix Polio is not recommended for use in pregnant women because safety data are limited. Women who are breastfeeding should consult their healthcare provider, as the vaccine is generally intended for infants rather than for maternal administration.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Infanrix Polio is a licensed, EU‑approved combination vaccine that includes aluminium‑hydroxide‑adsorbed pertussis antigens, offering comparable immunogenicity to other DTP‑Polio products such as Daptacel or Pentacel. Differences may lie in specific antigen formulations, adjuvant content and regulatory approvals, but all aim to provide protection against the same four diseases.

The vaccine must be stored at 2‑8 °C, protected from light, and kept in its original packaging. It should never be frozen or shaken. If temperature excursions occur, discard the product according to the manufacturer’s guidance.

Infanrix Polio is given by intramuscular injection, usually into the anterolateral thigh of infants or the deltoid muscle of older children, following the recommended immunisation schedule. Administration should be performed by a qualified healthcare professional.

The most serious adverse events include severe allergic reactions (anaphylaxis), seizures, high‑grade fever, and rare neurologic complications such as encephalopathy. Any signs of a serious reaction require immediate medical attention.

Infanrix Polio is contraindicated in individuals with a known severe allergy to any vaccine component, including aluminium salts, or in those who have experienced a previous severe reaction to a DTP‑Polio vaccine. Children with severe immunodeficiency should receive the vaccine only after specialist evaluation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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