Product image of Infanrix Polio (Poliovirus (Inactivated) Type 3 (Saukett Strain), Pertussis Filamentous Haemagglutinin Adsorbed On A) supplied by GNH India

Infanrix Polio

Active Ingredient:
Poliovirus (Inactivated) Type 3 (Saukett Strain), Pertussis Filamentous Haemagglutinin Adsorbed On A
Origin:
EU

Infanrix Polio (Poliovirus (Inactivated) Type 3 (Saukett Strain), Pertussis Filamentous Haemagglutinin Adsorbed On A)

Poliovirus (inactivated) type 3 (Saukett strain), the active ingredient in Infanrix Polio, is a vaccine presented as an unspecified strength/injectable vaccine for intramuscular use. It provides active immunization against diphtheria, tetanus, pertussis and poliomyelitis in infants and young children.

GNH India supplies Infanrix Polio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Ab

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Indications & Clinical Uses

Infanrix Polio is a combination vaccine that targets bacterial toxins and viral particles to prevent several childhood infectious diseases.

  • Diphtheria: induces protective antibodies that prevent diphtheria infection.
  • Tetanus: stimulates immunity that blocks tetanus toxin effects.
  • Pertussis (whooping cough): generates antibodies against pertussis antigens to reduce disease severity.
  • Poliomyelitis: creates immunity to poliovirus types, preventing paralytic poliomyelitis.

How It Works

  • Infanrix Polio contains inactivated poliovirus type 3, diphtheria and tetanus toxoids, and acellular pertussis antigens adsorbed onto an aluminum adjuvant. After intramuscular injection, the antigens are taken up by antigen‑presenting cells, prompting B‑cell and T‑cell activation and the production of specific antibodies that neutralize diphtheria toxin, tetanus toxin, pertussis factors, and poliovirus, thereby establishing active immunity.

Side Effects

Common Side Effects

  • Injection site pain, redness or swelling.
  • Low‑grade fever within 24‑48 hours.
  • Irritability or fussiness in infants.
  • Mild headache or fatigue.
  • Decreased appetite.

Serious or Rare Side Effects

  • Anaphylactic reaction (hives, breathing difficulty).
  • Seizures or high fever.
  • Prolonged crying episodes.
  • Guillain‑Barré syndrome (very rare).
  • Hypotonic‑hyporesponsive episodes.

Precautions & Warnings

Before administration, consider the following precautions:

  • Allergy history: avoid if severe allergy to any vaccine component.
  • Acute illness: postpone if the child has moderate or severe fever.
  • Immunocompromised status: assess risk, though vaccine is inactivated.
  • Concomitant vaccines: follow recommended intervals for live vaccines.
  • Monitoring: observe for at least 15 minutes post‑injection for immediate reactions.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Major Interactions (Avoid)

  • Immunoglobulin therapy: may diminish vaccine‑induced immunity.
  • Blood products administered shortly before or after vaccination.
  • Live attenuated vaccines given concurrently.

Moderate Interactions (Monitor Closely)

  • Antipyretics (e.g., acetaminophen) may mask fever, monitor temperature.
  • Systemic corticosteroids: could blunt immune response.
  • Other immunomodulatory agents: assess timing relative to vaccination.

Frequently Asked Questions

Infanrix Polio is a combination vaccine used to protect infants and young children against four serious diseases: diphtheria, tetanus, pertussis (whooping cough) and poliomyelitis. By stimulating the immune system, it helps prevent infection and the severe complications associated with each disease.

The poliovirus component contains inactivated type 3 poliovirus (Saukett strain). When injected, the virus particles cannot cause disease but are recognized by the immune system, prompting the production of neutralising antibodies that protect against future exposure to wild poliovirus.

The dosing schedule for Infanrix Polio is determined by the prescribing healthcare professional based on national immunisation guidelines. Typically, the vaccine is given as a series of intramuscular injections at specific ages in infancy, but the exact timing and number of doses are set by the prescriber.

Data on the use of Infanrix Polio during pregnancy are limited, and the vaccine is generally not recommended for pregnant women unless the potential benefits outweigh any theoretical risks. The vaccine is considered compatible with breastfeeding, but mothers should consult their healthcare provider for personalized advice.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Infanrix Polio is an EU‑licensed, fully adsorbed combination vaccine that includes inactivated poliovirus type 3, diphtheria and tetanus toxoids, and acellular pertussis antigens. Compared with some alternatives, it uses a specific pertussis filamentous haemagglutinin component and a defined poliovirus strain, offering comparable efficacy and a safety profile consistent with other licensed DTaP‑IPV products.

Infanrix Polio must be stored refrigerated at 2 °C to 8 °C. It should be kept in the original packaging to protect from light, must not be frozen, and should not be shaken. Before use, allow the vial to reach room temperature for a short period if required by the label.

The vaccine is administered by a trained healthcare professional as an intramuscular injection, usually into the anterolateral thigh of infants. The injection site is cleaned with an appropriate antiseptic, and the recommended volume is drawn into a sterile syringe before administration.

Serious adverse events are rare but may include anaphylaxis, seizures, Guillain‑Barré syndrome, and prolonged hypotonic‑hyporesponsive episodes. Immediate medical attention is required if signs of a severe allergic reaction (such as difficulty breathing, swelling of the face or throat) or neurological symptoms occur after vaccination.

Infanrix Polio should be avoided in individuals with a known severe allergy to any vaccine component, including the aluminium adjuvant, or in those who have experienced a previous severe reaction to a DTaP‑IPV vaccine. Children with a moderate or severe acute illness should have vaccination postponed until recovery.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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