Product image of Infanrix-Polio+hib (Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate), Poliovirus (Inactivated) Type 3 (Sa) supplied by GNH India

Infanrix-Polio+hib

Active Ingredient:
Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate), Poliovirus (Inactivated) Type 3 (Sa
Origin:
EU

Infanrix-Polio+hib (Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate), Poliovirus (Inactivated) Type 3 (Sa)

Haemophilus Type B Conjugate Vaccine (Tetanus Toxoid Conjugate), the active ingredient in Infanrix-Polio+hib, is a vaccine presented as an injectable solution for intramuscular use. It prevents diphtheria, tetanus, pertussis, Haemophilus influenzae type b disease, and poliomyelitis in infants and young children.

GNH India supplies Infanrix-Polio+hib as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Biologicals S.A.

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Indications & Clinical Uses

Infanrix-Polio+hib is a combination vaccine that targets several bacterial and viral agents responsible for serious childhood diseases.

  • Diphtheria: induces protective antibodies that prevent diphtheria toxin effects.
  • Tetanus: stimulates immunity against tetanus neurotoxin.
  • Pertussis (whooping cough): generates antibodies to Bordetella pertussis antigens.
  • Haemophilus influenzae type b disease: provides conjugate‑induced protection against invasive Hib infections.
  • Poliomyelitis: elicits immunity to poliovirus types 1, 2 and 3, preventing paralytic polio.

How It Works

  • The vaccine contains purified antigens from diphtheria toxin, tetanus toxoid, acellular pertussis components, Haemophilus influenzae type b polysaccharide conjugated to tetanus toxoid, and inactivated poliovirus types 1‑3. After intramuscular injection, antigen‑presenting cells process these components, leading to B‑cell activation and production of specific antibodies, while T‑cell help supports long‑lasting immune memory against each pathogen.

Side Effects

Common Side Effects

  • Pain at injection site: mild to moderate discomfort where the vaccine is administered.
  • Redness or swelling: localized inflammatory reaction.
  • Fever: transient rise in body temperature.
  • Irritability or crying: especially in infants.
  • Loss of appetite: temporary decrease in feeding.
  • Fatigue: mild tiredness after vaccination.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: rare neurologic events post‑vaccination.
  • High fever (≥40°C): may need antipyretic treatment.
  • Prolonged crying (≥3 hours): indicative of possible severe reaction.
  • Hypotonic‑hyporesponsive episode: sudden loss of muscle tone in infants.
  • Guillain‑Barré syndrome: extremely rare autoimmune neuropathy.

Precautions & Warnings

Infanrix-Polio+hib should be administered according to approved pediatric immunisation schedules.

  • Allergy: avoid if the patient has a known hypersensitivity to any vaccine component.
  • Medical conditions: consult a healthcare professional if the child is immunocompromised or has a severe acute illness.
  • Concurrent vaccines: follow recommended intervals when co‑administering with other vaccines.
  • Pregnancy: not indicated for use in pregnant women; defer vaccination until after delivery.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Vaccination may be influenced by other medical products.

Major Interactions (Avoid)

  • Live attenuated vaccines: avoid administration within 4 weeks before or after this vaccine.
  • Immunoglobulin or blood products: may diminish the immune response if given concurrently.

Moderate Interactions (Monitor Closely)

  • Antipyretics (e.g., acetaminophen): can mask fever, monitor for underlying reactions.
  • Systemic corticosteroids: may blunt antibody production.
  • Other inactivated vaccines: generally safe but observe for additive local reactions.
  • Antibiotics: no significant interaction, but monitor for infection control.

Frequently Asked Questions

Infanrix-Polio+hib is a combination vaccine indicated for the prevention of diphtheria, tetanus, pertussis (whooping cough), Haemophilus influenzae type b disease, and poliomyelitis caused by poliovirus types 1, 2 and 3 in infants and young children.

The vaccine contains purified antigens from each target pathogen. After intramuscular injection, these antigens are taken up by antigen‑presenting cells, stimulating B‑cell and T‑cell responses that generate specific antibodies and immunologic memory, thereby providing active protection against the diseases.

The dosing schedule for Infanrix-Polio+hib is determined by the prescribing healthcare professional based on national immunisation guidelines. The prescriber decides the number of doses, timing, and intervals appropriate for each patient.

Infanrix-Polio+hib is not indicated for use in pregnant women. If vaccination is required, it should be deferred until after delivery. Limited data are available for breastfeeding mothers; the decision should be made by a qualified healthcare provider weighing potential benefits and risks.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and necessary import documentation.

Infanrix-Polio+hib combines DTaP, Hib conjugate, and inactivated poliovirus antigens in a single injection, reducing the number of separate shots needed. Compared with separate monovalent vaccines, it simplifies the immunisation schedule while offering comparable immunogenicity and safety profiles.

The vaccine must be stored refrigerated at 2 °C to 8 °C. It should be kept in its original packaging, protected from light, and must never be frozen or shaken. Proper cold‑chain management is essential to maintain potency.

Infanrix-Polio+hib is given as an intramuscular injection, typically into the anterolateral thigh of infants or the deltoid muscle of older children, according to the recommended immunisation schedule.

The most serious adverse events are rare and include severe allergic reactions such as anaphylaxis, seizures, high fever, prolonged crying episodes, and very rare neurologic conditions like Guillain‑Barré syndrome. Immediate medical attention is required if any of these occur.

Infanrix-Polio+hib should not be administered to individuals with a known severe allergy to any vaccine component, or to those who have experienced a previous severe reaction to a DTaP‑Hib‑IPV vaccine. It is also contraindicated in pregnant women and should be used with caution in immunocompromised patients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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