Infectocef 500 Saft (Cefaclor Monohydrate)

Cefaclor is a second‑generation cephalosporin used to treat bacterial infections of the respiratory and related systems.

• Upper respiratory tract infections: Reduces bacterial load and alleviates symptoms such as cough and sore throat.
• Acute otitis media: Clears middle‑ear infection and improves hearing discomfort.
• Sinusitis: Eliminates pathogenic bacteria in the sinus cavities, relieving facial pain and congestion.
• Skin and soft tissue infections: Controls bacterial proliferation in cellulitis and wound infections.

• Cefaclor inhibits bacterial cell wall synthesis by binding to penicillin‑binding proteins (PBPs) located on the bacterial membrane. This binding interferes with the cross‑linking of peptidoglycan strands, weakening the cell wall and leading to osmotic instability and bacterial lysis. The drug is bactericidal against susceptible Gram‑positive and Gram‑negative organisms.

Adverse reactions may occur with cefaclor use and are categorized by frequency.

Common Side Effects

• Diarrhea: Mild to moderate loose stools.
• Nausea: Transient feeling of queasiness.
• Vomiting: Occasional emesis.
• Abdominal pain: Cramping or discomfort.
• Rash: Non‑specific skin erythema.
• Taste disturbance: Altered taste perception.

Serious or Rare Side Effects

• Anaphylaxis: Severe allergic reaction with airway compromise.
• Stevens‑Johnson syndrome: Rare mucocutaneous blistering disorder.
• Clostridioides difficile‑associated diarrhea: Severe colitis.
• Hematologic abnormalities: Neutropenia or eosinophilia.
• Hepatic enzyme elevation: Transient increase in liver transaminases.

Before prescribing cefaclor, clinicians should consider several safety aspects.

• Allergy assessment: Confirm no known hypersensitivity to cephalosporins or penicillins.
• Renal function: Adjust dosage in patients with impaired kidney function.
• Pregnancy and lactation: Use only if potential benefits outweigh uncertain risks.
• Drug interactions: Review concomitant medications for possible interaction.
• Treatment adherence: Complete the full prescribed course to prevent resistance.
• Store at ambient temperature: Keep below 25 °C, protect from moisture and light in the original container.

Cefaclor may interact with other medicines, requiring caution.

Major Interactions (Avoid)

• Probenecid: Increases cefaclor plasma concentrations, raising toxicity risk.
• Warfarin: May potentiate anticoagulant effect, increasing bleeding risk.
• Live bacterial vaccines: May diminish vaccine efficacy.
• Aminoglycosides: Combined use can heighten nephrotoxicity.

Moderate Interactions (Monitor Closely)

• Oral contraceptives: Potential reduction in effectiveness; advise backup contraception.
• Loop diuretics: May exacerbate electrolyte disturbances when used together.