Product image of Infectocortikrupp (Prednisolone Acetate) supplied by GNH India

Infectocortikrupp

Active Ingredient:
Prednisolone Acetate
Origin:
EU

Infectocortikrupp (Prednisolone Acetate)

Prednisolone acetate, the active ingredient in Infectocortikrupp, is a corticosteroid presented as a rectal formulation for rectal use. It provides anti‑inflammatory and immunosuppressive effects for conditions affecting the lower gastrointestinal tract.

GNH India supplies Infectocortikrupp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Infectopharm Arzneimittel Und Consilium Gmbh, De, Heppenheim

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Indications & Clinical Uses

Prednisolone acetate is a corticosteroid that reduces inflammation in the gastrointestinal tract.

  • Ulcerative colitis: reduces mucosal inflammation and helps maintain remission in the colon.
  • Proctitis: alleviates rectal inflammation, decreasing bleeding, urgency and discomfort.
  • Rectal inflammatory disease: provides localized anti‑inflammatory action to control flare‑ups of lower GI inflammation.

How It Works

  • Prednisolone acetate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This interaction suppresses pro‑inflammatory cytokine production, inhibits leukocyte migration, and reduces vascular permeability, resulting in potent anti‑inflammatory and immunosuppressive effects at the site of administration.

Side Effects

Common Side Effects

  • Rectal irritation or burning sensation
  • Discharge or spotting
  • Headache
  • Nausea or mild stomach upset
  • Increased appetite
  • Mild insomnia

Serious or Rare Side Effects

  • Adrenal suppression or insufficiency
  • Severe systemic infection
  • Hyperglycemia or worsening diabetes
  • Osteoporosis with long‑term use
  • Cataracts or glaucoma
  • Anaphylactic or severe allergic reaction

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess for active infections: avoid use if uncontrolled infection is present.
  • Monitor blood glucose: patients with diabetes may require dose adjustments.
  • Evaluate adrenal function: prolonged use can suppress the hypothalamic‑pituitary‑adrenal axis.
  • Use with caution in patients with hypertension or cardiovascular disease.
  • Limit duration: avoid long‑term continuous use without medical supervision.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Prednisolone acetate may interact with several medicines.

Major Interactions (Avoid)

  • Systemic CYP3A4 inhibitors (e.g., ketoconazole) – may increase corticosteroid levels.
  • Systemic CYP3A4 inducers (e.g., rifampicin) – may reduce efficacy.
  • Live vaccines – risk of uncontrolled infection.
  • Anticoagulants (e.g., warfarin) – may enhance anticoagulant effect.
  • NSAIDs – increased risk of gastrointestinal ulceration.

Moderate Interactions (Monitor Closely)

  • Diuretics – may exacerbate potassium loss.
  • Antidiabetic agents – may require dose adjustment due to hyperglycemia.
  • Antihypertensives – possible reduction in blood pressure control.

Frequently Asked Questions

Infectocortikrupp contains prednisolone acetate and is used as a rectal corticosteroid to treat inflammatory conditions of the lower gastrointestinal tract, such as ulcerative colitis, proctitis, and other forms of rectal inflammation. It works locally to reduce swelling, pain, and bleeding associated with these disorders.

Prednisolone acetate binds to glucocorticoid receptors inside cells, altering gene expression to suppress the production of inflammatory cytokines and chemokines. This reduces leukocyte infiltration, vascular permeability, and overall inflammatory response, providing potent anti‑inflammatory and immunosuppressive effects at the site of administration.

The specific dose and frequency of Infectocortikrupp are determined by the prescribing clinician based on the severity of the condition, patient age, and response to therapy. Healthcare providers tailor the regimen to achieve optimal therapeutic benefit while minimizing potential risks.

Safety data for rectal prednisolone acetate in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant. Clinicians typically evaluate each case individually and may consider alternative therapies when possible.

To place an order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Infectocortikrupp (prednisolone acetate) offers a higher glucocorticoid potency than rectal hydrocortisone preparations, allowing effective inflammation control at lower doses. Compared with budesonide suppositories, it may have a longer duration of action but shares similar safety considerations, such as the risk of systemic absorption with prolonged use.

Infectocortikrupp should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme temperatures or humidity, which could affect its stability.

The medication is supplied as a rectal formulation, typically a suppository or enema. It is inserted into the rectum according to the prescriber's instructions, usually after bowel movements and before bedtime, to maximize local absorption and minimize leakage.

Serious risks include adrenal suppression, severe systemic infections, hyperglycemia, osteoporosis with long‑term use, and rare allergic reactions such as anaphylaxis. Patients should be monitored for signs of infection, abnormal blood sugar levels, and any unexpected systemic effects, especially during extended therapy.

Infectocortikrupp is contraindicated in patients with known hypersensitivity to prednisolone acetate or any component of the formulation, and in those with uncontrolled systemic infections. Caution is also advised for individuals with uncontrolled diabetes, severe hypertension, or a history of peptic ulcer disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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